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Topic · Molecular Biology

Phosphodiesterase function and regulation

Phosphodiesterase function and regulation is a research topic within Molecular Biology. Science Explorer counts 10k research works in it since 1952. 19.7% of them reached the world's top 10% most cited for their field and year.

This cluster of papers focuses on the molecular regulation and clinical applications of cyclic nucleotide phosphodiesterases (PDEs), particularly in the context of cAMP signaling, schizophrenia genetics, neuronal development, therapeutic targeting, compartmentalized signaling, Alzheimer's disease treatment, cardiac function regulation, and the development of phosphodiesterase inhibitors.

  • Cyclic Nucleotide Phosphodiesterases
  • cAMP Signaling
  • Schizophrenia Genetics
  • Neuronal Development
  • Therapeutic Targets
  • Compartmentalized Signaling
  • Alzheimer's Disease Treatment
  • Cardiac Function Regulation
  • Phosphodiesterase Inhibitors
  • G Protein-Coupled Receptors
Research works
10k
fractional, since 1952
In the world top 10%
2k
per year above
Top-10% rate
19.7%
share of its works in the world top 10%
Growth, 2013–17 → 2018–22
-11%
the tick is no change

Which countries lead Phosphodiesterase function and regulation research?

By volume, China and the United States publish the most (300 and 298 works in 2022–2025).

By volume, 2022–2025

  1. 1 China 300 works
  2. 2 United States 298 works
  3. 3 India 89 works
  4. 4 Germany 73 works
  5. 5 United Kingdom 62 works
  6. 6 Italy 55 works
  7. 7 Japan 43 works
  8. 8 South Korea 38 works
  9. 9 Canada 32 works
  10. 10 France 29 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

China: 29.4%United States: 29.3%India: 8.7%Germany: 7.1%6 others listed: 25.4%29%largest
China300 · 29.4%United States298 · 29.3%India89 · 8.7%Germany73 · 7.1%6 others listed259 · 25.4%

Shares of the rows listed above, not of the whole node.

Which institutions lead Phosphodiesterase function and regulation research?

By volume in 2022–2025, Boehringer Ingelheim (Germany) publishes the most Phosphodiesterase function and regulation research, followed by Chinese Academy of Medical Sciences & Peking Union Medical College and Sun Yat-sen University.

By volume, 2022–2025

  1. 1 Boehringer Ingelheim (Germany)Germany 7 works
  2. 2 Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 6 works
  3. 3 Sun Yat-sen UniversityChina 6 works
  4. 4 University of North Carolina at Chapel HillUnited States 5 works
  5. 5 University of OxfordUnited Kingdom 5 works
  6. 6 University of RochesterUnited States 5 works
  7. 7 Hainan UniversityChina 5 works
  8. 8 Peking UniversityChina 4 works
  9. 9 Merck & Co., Inc., Rahway, NJ, USA (United States)United States 4 works
  10. 10 Cairo UniversityEgypt 4 works

Where is Phosphodiesterase function and regulation research done?

The largest centres of Phosphodiesterase function and regulation research in 2022–2025 are Beijing (China), Guangzhou (China), London (United Kingdom) and Shanghai (China). Among places with at least 20 works in it, it is an unusually large share of all research in Guangzhou.

Largest cities, 2022–2025

  1. 1 Beijing China 38 works
  2. 2 Guangzhou China 30 works
  3. 3 London United Kingdom 21 works
  4. 4 Shanghai China 21 works
  5. 5 Seoul South Korea 20 works
  6. 6 Tokyo Japan 15 works
  7. 7 New York United States 14 works
  8. 8 Nanjing China 13 works
  9. 9 Paris France 13 works
  10. 10 Chengdu China 13 works

Where it is the local speciality

  1. GuangzhouCN · 30.0 works2.5×
← less than its size predicts1×more →

Location quotient: how much more of its research is in Phosphodiesterase function and regulation than the world average.

See Phosphodiesterase function and regulation on the map

Is Phosphodiesterase function and regulation research growing?

Output in 2018–2022 was 11% lower than in 2013–2017, peaking in 2026. The fastest-growing topics are Phosphodiesterase function and regulation.

19801990200020102020
grewheldshrank

The same series as a ribbon — one cell per year, darker for more. The line above answers how much; this answers when.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.