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Topic · Molecular Biology

Phosphodiesterase function and regulation

Phosphodiesterase function and regulation is a research topic within Molecular Biology. Science Explorer counts 10k research works in it since 1952. 10.2% of them reached the world's top 10% most cited for their field and year.

This cluster of papers focuses on the molecular regulation and clinical applications of cyclic nucleotide phosphodiesterases (PDEs), particularly in the context of cAMP signaling, schizophrenia genetics, neuronal development, therapeutic targeting, compartmentalized signaling, Alzheimer's disease treatment, cardiac function regulation, and the development of phosphodiesterase inhibitors.

  • Cyclic Nucleotide Phosphodiesterases
  • cAMP Signaling
  • Schizophrenia Genetics
  • Neuronal Development
  • Therapeutic Targets
  • Compartmentalized Signaling
  • Alzheimer's Disease Treatment
  • Cardiac Function Regulation
  • Phosphodiesterase Inhibitors
  • G Protein-Coupled Receptors
Research works
10k
fractional, since 1952
In the world top 10%
1k
per year above
Top-10% rate
10.2%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
+17%
the tick is no change
Largest producer
United States
31% of the 10 largest, 2022-now
Phosphodiesterase function and regulation

Which countries lead Phosphodiesterase function and regulation research?

By volume, the United States and China publish the most (442 and 426 works in 2022-now).

By volume, 2022-now

  1. 1 United States 442 works
  2. 2 China 426 works
  3. 3 India 137 works
  4. 4 Germany 96 works
  5. 5 United Kingdom 79 works
  6. 6 Italy 78 works
  7. 7 Japan 56 works
  8. 8 South Korea 47 works
  9. 9 Canada 42 works
  10. 10 Spain 40 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

United States: 30.6%China: 29.5%India: 9.5%Germany: 6.6%6 others listed: 23.7%31%largest
United States442 · 30.6%China426 · 29.5%India137 · 9.5%Germany96 · 6.6%6 others listed343 · 23.7%

Shares of the rows listed above, not of the whole node.

Which institutions lead Phosphodiesterase function and regulation research?

By volume in 2022-now, Harvard University publishes the most Phosphodiesterase function and regulation research, followed by Boehringer Ingelheim (Germany) and National Institutes of Health.

By volume, 2022-now

  1. 1 Harvard UniversityUnited States 16 works
  2. 2 Boehringer Ingelheim (Germany)Germany 14 works
  3. 3 National Institutes of HealthUnited States 11 works
  4. 4 Russian Academy of SciencesRussia 10 works
  5. 5 Sun Yat-sen UniversityChina 10 works
  6. 6 InsermFrance 9 works
  7. 7 Chinese Academy of SciencesChina 9 works
  8. 8 Peking UniversityChina 9 works
  9. 9 Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 9 works
  10. 10 Zhejiang UniversityChina 9 works

Who are the leading researchers in Phosphodiesterase function and regulation?

The most-cited researchers publishing on Phosphodiesterase function and regulation include John J.V. McMurray, Graeme J. Hankey and Dan J. Stein.

  1. 1 John J.V. McMurray United Kingdom 349k citations
  2. 2 Graeme J. Hankey Australia 316k citations
  3. 3 Dan J. Stein South Africa 306k citations
  4. 4 Matthew M. Meyerson United States 280k citations
  5. 5 Josep María Haro Spain 250k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Phosphodiesterase function and regulation?

The most cited paper in Phosphodiesterase function and regulation is "Sildenafil Citrate Therapy for Pulmonary Arterial Hypertension" (Nazzareno Galiè, Hossein Ardeschir Ghofrani, Adam Torbicki et al., 2005), with 2,489 citations. Next come "Oral Sildenafil in the Treatment of Erectile Dysfunction" (2,158) and "Second-generation versus first-generation antipsychotic drugs for schizophrenia: a meta-analysis" (1,936).

Most cited papers
#PaperReleasedCitations
1 Sildenafil Citrate Therapy for Pulmonary Arterial Hypertension Nazzareno Galiè, Hossein Ardeschir Ghofrani, Adam Torbicki et al. · New England Journal of Medicine Open access 16 Nov 2005 2,489
2 Oral Sildenafil in the Treatment of Erectile Dysfunction Irwin Goldstein, Tom F. Lue, Harin Padma-Nathan et al. · New England Journal of Medicine 14 May 1998 2,158
3 Second-generation versus first-generation antipsychotic drugs for schizophrenia: a meta-analysis Stefan Leucht, Caroline Corves, Dieter Arbter et al. · The Lancet Review 7 Dec 2008 1,936
4 Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms Joseph A. Beavo · Physiological Reviews Oct 1995 1,793
5 Cyclic Nucleotide Phosphodiesterases: Molecular Regulation to Clinical Use Andrew T. Bender, Joseph A. Beavo · Pharmacological Reviews Sep 2006 1,793
All 100 most cited papers, with filters and sorting

Where is Phosphodiesterase function and regulation research done?

The largest centres of Phosphodiesterase function and regulation research in 2022-now are Beijing (China), Guangzhou (China), Shanghai (China) and London (United Kingdom).

Largest cities, 2022-now

  1. 1 BeijingChina 50 works
  2. 2 GuangzhouChina 37 works
  3. 3 ShanghaiChina 29 works
  4. 4 LondonUnited Kingdom 29 works
  5. 5 SeoulSouth Korea 24 works
  6. 6 New YorkUnited States 19 works
  7. 7 TokyoJapan 19 works
  8. 8 NanjingChina 18 works
  9. 9 ParisFrance 17 works
  10. 10 ChengduChina 17 works
See Phosphodiesterase function and regulation on the map

Where is the best place to study Phosphodiesterase function and regulation?

Among universities, judged by research, Harvard University, Sichuan University and Peking University score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%10%20%mean 11.1125%fractional works in this field (log) →share of work in the world top 10% →Harvard UniversitySichuan UniversityPeking UniversityChinese Academy of M…
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Harvard UniversityUnited States 87.619.2%3.0×16 -9.4%
2Sichuan UniversityChina 38.718.2%2.2×8 +95.0%
3Peking UniversityChina 31.811.8%2.6×9 +160.8%
4Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 27.98.5%5.0×9 +136.1%
5Sun Yat-sen UniversityChina 18.87.4%2.8×10 -19.4%
6Zhejiang UniversityChina 18.08.6%2.0×9 +275.1%
7Shanghai Jiao Tong UniversityChina 15.47.3%1.8×9 +48.4%
8Central South UniversityChina 15.27.9%2.6×8 +53.6%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Phosphodiesterase function and regulation, country by country

Is Phosphodiesterase function and regulation research growing?

Output in 2022-2025 was 17% higher than in 2018-2021, peaking in 2026. The fastest-growing topics are Phosphodiesterase function and regulation.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Phosphodiesterase function and regulation as a percentage of every work published that year, 0.0058% in 2024.

still counting0.010%0.020%Phosphodiesterase function and regulation0.0091% in 202519801990200020102020

Fractional works of Phosphodiesterase function and regulation over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Phosphodiesterase function and regulation10.2% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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