Most cited papers in Ubiquitin and proteasome pathways
What are the most cited papers in Ubiquitin and proteasome pathways?
The most cited paper in Ubiquitin and proteasome pathways is "THE UBIQUITIN SYSTEM" (Avram Hershko, Aaron J. Ciechanover, 1998), with 8,852 citations. Next come "A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes" (8,489) and "p53, the Cellular Gatekeeper for Growth and Division" (7,766).
Showing 50 of 100 papers. Every paper with more than 1,901 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | THE UBIQUITIN SYSTEM Avram Hershko, Aaron J. Ciechanover · Annual Review of Biochemistry | Jun 1998 | 8,852 |
| 2 | A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes Marcy E. MacDonald · Cell | Mar 1993 | 8,489 |
| 3 | p53, the Cellular Gatekeeper for Growth and Division Arnold J. Levine · Cell | Feb 1997 | 7,766 |
| 4 | LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing Yukihiro Kabeya, Noboru Mizushima, Takashi Ueno et al. · The EMBO Journal | Nov 2000 | 6,650 |
| 5 | CDK inhibitors: positive and negative regulators of G1-phase progression Charles J. Sherr, Joanna Roberts · Genes & Development | 15 Jun 1999 | 6,153 |
| 6 | Molecular mechanisms and clinical applications of angiogenesis Peter Carmeliet, Rakesh K. Jain · Nature | May 2011 | 5,504 |
| 7 | Hypoxia — a key regulatory factor in tumour growth Adrian L. Harris · Nature reviews. Cancer | 2002 | 5,228 |
| 8 | The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains Steven K. Hanks, Anne Marie Quinn, Tony R. Hunter · Science | Jul 1988 | 5,150 |
| 9 | The retinoblastoma protein and cell cycle control Robert A. Weinberg · Cell | May 1995 | 4,913 |
| 10 | Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein Nathan C. Shaner, Robert E. Campbell, Paul A. Steinbach et al. · Nature Biotechnology | 21 Nov 2004 | 4,783 |
| 11 | Dystrophin: The protein product of the duchenne muscular dystrophy locus Eric P. Hoffman, Robert H. Brown, Louis M. Kunkel · Cell | Dec 1987 | 4,742 |
| 12 | In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2 Lyubomir T. Vassilev, Binh Thanh Vu, Bradford J. Graves et al. · Science | 5 Jan 2004 | 4,741 |
| 13 | p62/SQSTM1 Binds Directly to Atg8/LC3 to Facilitate Degradation of Ubiquitinated Protein Aggregates by Autophagy Serhiy Pankiv, Terje Høyvarde Clausen, Trond Lamark et al. · Journal of Biological Chemistry | 19 Jun 2007 | 4,649 |
| 14 | STRING v9.1: protein-protein interaction networks, with increased coverage and integration Andrea Franceschini, Damian Szklarczyk, Sune Pletscher-Frankild et al. · Nucleic Acids Research | 29 Nov 2012 | 4,592 |
| 15 | Mdm2 promotes the rapid degradation of p53 Ygal Haupt, Ruth Ben-Yakar Maya, Anat Kazaz et al. · Nature | May 1997 | 4,575 |
| 16 | The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction Michael H. Glickman, Aaron J. Ciechanover · Physiological Reviews | Apr 2002 | 4,266 |
| 17 | A simple technique for demonstrating centromeric heterochromatin Adrian T. Sumner · Experimental Cell Research | Nov 1972 | 4,257 |
| 18 | Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions Chunaram Choudhary, Chanchal Kumar, Florian Gnad et al. · Science | 16 Jul 2009 | 4,088 |
| 19 | Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis Donald W. Nicholson, Ambereen Ali, Nancy A. Thornberry et al. · Nature | Jul 1995 | 4,026 |
| 20 | Cell cycle, CDKs and cancer: a changing paradigm Marcos Malumbres, Mariano Barbacid · Nature reviews. Cancer | 24 Feb 2009 | 4,023 |
| 21 | Mechanisms Underlying Ubiquitination Cecile M. Pickart · Annual Review of Biochemistry | Jun 2001 | 3,771 |
| 22 | The Ubiquitin Code David Komander, Michael Rapé · Annual Review of Biochemistry | 22 May 2012 | 3,767 |
| 23 | A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4 Manuel Serrano, Gregory James Hannon, David Beach · Nature | Dec 1993 | 3,697 |
| 24 | Autophagy as a Regulated Pathway of Cellular Degradation Daniel J. Klionsky, Scott D. Emr · Science | Dec 2000 | 3,633 |
| 25 | Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome Annemieke J.M.H. Verkerk et al. · Cell | May 1991 | 3,540 |
| 26 | High Frequency of Mutations of the PIK3CA Gene in Human Cancers Yardena Samuels, Zhenghe Wang, Alberto Bardelli et al. · Science | 15 Mar 2004 | 3,473 |
| 27 | Proliferation, cell cycle and apoptosis in cancer Gérard I. Evan, Karen H. Vousden · Nature | May 2001 | 3,427 |
| 28 | The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation Peter E. Angel, Michael Karin · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer | Dec 1991 | 3,422 |
| 29 | p21 is a universal inhibitor of cyclin kinases Yue Xiong, Gregory James Hannon, Hui Zhang et al. · Nature | Dec 1993 | 3,400 |
| 30 | Principles of CDK regulation David O. Morgan · Nature | Mar 1995 | 3,325 |
| 31 | PROTAC targeted protein degraders: the past is prologue Miklós Békés, David R. Langley, Craig M. Crews · Nature Reviews Drug Discovery | 18 Jan 2022 | 3,294 |
| 32 | Inhibitors of mammalian G1 cyclin-dependent kinases. Charles J. Sherr, Joanna Roberts · Genes & Development | 15 May 1995 | 3,273 |
| 33 | The SWISS-PROT protein sequence database and its supplement TrEMBL in 2000 Amos Bairoch · Nucleic Acids Research | 2000 | 3,251 |
| 34 | Live or let die: the cell's response to p53 Karen H. Vousden, Xin Lü · Nature reviews. Cancer | Aug 2002 | 3,202 |
| 35 | The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation Jamil Antonio Momand, Gerard P. Zambetti, David C. Olson et al. · Cell | Jun 1992 | 3,151 |
| 36 | Exon 1 of the HD Gene with an Expanded CAG Repeat Is Sufficient to Cause a Progressive Neurological Phenotype in Transgenic Mice Laura Mangiarini, Kirupa Sathasivam, Mary J. Seller et al. · Cell | Nov 1996 | 3,116 |
| 37 | RHO GTPASES: Biochemistry and Biology Aron B. Jaffe, Alan K. Hall · Annual Review of Cell and Developmental Biology | 28 Jun 2005 | 3,071 |
| 38 | Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor Peter E. Angel, Masayoshi Imagawa, Robert Chiu et al. · Cell | Jun 1987 | 3,027 |
| 39 | Protein kinases and phosphatases: The Yin and Yang of protein phosphorylation and signaling Tony R. Hunter · Cell | 1995 | 2,985 |
| 40 | The Transcriptional Coactivators p300 and CBP Are Histone Acetyltransferases Vasily V. Ogryzko, R. Louis Schiltz, Valya R. RUSSANOVA et al. · Cell | Nov 1996 | 2,981 |
| 41 | Epidermal Growth Factor G Carpenter, Stanley Cohen · Annual Review of Biochemistry | Jun 1979 | 2,938 |
| 42 | Histone acetylation in chromatin structure and transcription Michael Grunstein · Nature | Sep 1997 | 2,921 |
| 43 | Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain Andrew J. Bannister, Philip Zegerman, Janet F. Partridge et al. · Nature | Mar 2001 | 2,920 |
| 44 | An atlas of active enhancers across human cell types and tissues Robin Andersson et al. · Nature | Mar 2014 | 2,854 |
| 45 | PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1 Sven Geisler, Kira M. Holmström, Diana Skujat et al. · Nature Cell Biology | 24 Jan 2010 | 2,853 |
| 46 | The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy Michael Lazarou, Danielle A. Sliter, Lesley A. Kane et al. · Nature | Aug 2015 | 2,837 |
| 47 | Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers Peter A. Steck, Mark A. Pershouse, Samar A. Jasser et al. · Nature Genetics | Apr 1997 | 2,772 |
| 48 | RING Domain E3 Ubiquitin Ligases Raymond J. Deshaies, Claudio A.P. Joazeiro · Annual Review of Biochemistry | Jun 2009 | 2,715 |
| 49 | A Phase 2 Study of Bortezomib in Relapsed, Refractory Myeloma Paul Gerard Guy Richardson et al. · New England Journal of Medicine | 25 Jun 2003 | 2,656 |
| 50 | Serine Phosphorylation of Death Agonist BAD in Response to Survival Factor Results in Binding to 14-3-3 Not BCL-XL Jiping Zha, Hisashi Harada, Elizabeth Yang et al. · Cell | Nov 1996 | 2,633 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.