Institution · Structural Genomics Consortium
Most cited papers from Structural Genomics Consortium
What are the most cited papers from Structural Genomics Consortium?
The most cited paper from Structural Genomics Consortium is "The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability" (F. Niesen, Helena Berglund, Masoud Vedadi, 2007), with 2,481 citations. Next come "Histone Recognition and Large-Scale Structural Analysis of the Human Bromodomain Family" (1,794) and "Epigenetic protein families: a new frontier for drug discovery" (1,324).
Showing 50 of 60 papers. Every paper with more than 260 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability F. Niesen, Helena Berglund, Masoud Vedadi · Nature Protocols | Sep 2007 | 2,481 |
| 2 | Histone Recognition and Large-Scale Structural Analysis of the Human Bromodomain Family P. Filippakopoulos, S. Picaud, Maria Mangos et al. · Cell | Mar 2012 | 1,794 |
| 3 | Epigenetic protein families: a new frontier for drug discovery C.H. Arrowsmith, C. Bountra, Paul V. Fish et al. · Nature Reviews Drug Discovery | 13 Apr 2012 | 1,324 |
| 4 | Targeted protein degradation: expanding the toolbox Matthieu Schapira, Matthew F. Calabrese, Alex N. Bullock et al. · Nature Reviews Drug Discovery | 30 Oct 2019 | 983 |
| 5 | Consistent blind protein structure generation from NMR chemical shift data Yang Shen, Oliver F. Lange, Frank Delaglio et al. · Proceedings of the National Academy of Sciences | 7 Mar 2008 | 869 |
| 6 | The promise and peril of chemical probes C.H. Arrowsmith et al. · Nature Chemical Biology | 21 Jul 2015 | 864 |
| 7 | Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis Dimitrios Anastasiou et al. · Nature Chemical Biology | 26 Aug 2012 | 842 |
| 8 | Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell– and patient-derived tumor organoids Ling Huang et al. · Nature Medicine | 26 Oct 2015 | 759 |
| 9 | Structural basis for selective binding of m6A RNA by the YTHDC1 YTH domain Chao Xu, Xiao Wang, Ke Liu et al. · Nature Chemical Biology | 21 Sep 2014 | 727 |
| 10 | Structure and function of WD40 domain proteins Chao Xu, Jinrong Min · Protein & Cell | Mar 2011 | 675 |
| 11 | A proposal for validation of antibodies Mathias Uhlén, Anita E. Bandrowski, Steven A. Carr et al. · Nature Methods | 5 Sep 2016 | 660 |
| 12 | A Call for Systematic Research on Solute Carriers Adrián César‐Razquin, Berend Snijder, Tristan Frappier‐Brinton et al. · Cell | Jul 2015 | 626 |
| 13 | A systematic analysis of atomic protein–ligand interactions in the PDB Renato Ferreira de Freitas, Matthieu Schapira · MedChemComm | 2017 | 611 |
| 14 | Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination Masoud Vedadi, F. Niesen, Abdellah Allali‐Hassani et al. · Proceedings of the National Academy of Sciences | 11 Oct 2006 | 599 |
| 15 | Global analysis of protein folding using massively parallel design, synthesis, and testing Gabriel J. Rocklin, Tamuka M. Chidyausiku, Inna Goreshnik et al. · Science | 14 Jul 2017 | 580 |
| 16 | A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells Masoud Vedadi et al. · Nature Chemical Biology | 10 Jul 2011 | 539 |
| 17 | Self-renewal as a therapeutic target in human colorectal cancer Antonija Kreso, Peter van Galen, Nicholas Pedley et al. · Nature Medicine | Dec 2013 | 536 |
| 18 | Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth Jiajun Zhu, Morgan A. Sammons, Greg Donahue et al. · Nature | 2 Sep 2015 | 506 |
| 19 | Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1 G.V. Avvakumov, John R. Walker, Sheng Xue et al. · Nature | 3 Sep 2008 | 496 |
| 20 | An Orally Bioavailable Chemical Probe of the Lysine Methyltransferases EZH2 and EZH1 Kyle D. Konze et al. · ACS Chemical Biology | 8 Apr 2013 | 474 |
| 21 | Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors Elisabet Wahlberg, T. Karlberg, Ekaterina Kouznetsova et al. · Nature Biotechnology | 19 Feb 2012 | 465 |
| 22 | Protein arginine methylation: from enigmatic functions to therapeutic targeting Qin Wu, Matthieu Schapira, C.H. Arrowsmith et al. · Nature Reviews Drug Discovery | 19 Mar 2021 | 431 |
| 23 | Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy Xiaoyang Lan et al. · Nature | 29 Aug 2017 | 427 |
| 24 | Association of UHRF1 with methylated H3K9 directs the maintenance of DNA methylation Scott B. Rothbart, Krzysztof Krajewski, Nataliya Nady et al. · Nature Structural & Molecular Biology | 30 Sep 2012 | 387 |
| 25 | MYC protein interactors in gene transcription and cancer Corey Lourenco, Diana Resetca, Cornelia Redel et al. · Nature reviews. Cancer | 29 Jun 2021 | 364 |
| 26 | Structure of the p53 Binding Domain of HAUSP/USP7 Bound to Epstein-Barr Nuclear Antigen 1 V. Saridakis, Yi Sheng, Feroz Sarkari et al. · Molecular Cell | Apr 2005 | 364 |
| 27 | WD40 repeat domain proteins: a novel target class? Matthieu Schapira, Mike Tyers, Maricel Torrent et al. · Nature Reviews Drug Discovery | 13 Oct 2017 | 358 |
| 28 | Calcium-dependent protein kinase 1 is an essential regulator of exocytosis in Toxoplasma Sebastian Lourido, Joel L. Shuman, Chao Zhang et al. · Nature | May 2010 | 354 |
| 29 | Structural basis for pregnenolone biosynthesis by the mitochondrial monooxygenase system Natallia V. Strushkevich, Farrell MacKenzie, Tatyana Cherkesova et al. · Proceedings of the National Academy of Sciences | 2 Jun 2011 | 347 |
| 30 | Codon optimization can improve expression of human genes in Escherichia coli: A multi-gene study N. Burgess-Brown, Sujata Sharma, Frank Sobott et al. · Protein Expression and Purification | 28 Jan 2008 | 344 |
| 31 | Structural Basis for the Discriminative Recognition of N6-Methyladenosine RNA by the Human YT521-B Homology Domain Family of Proteins Chao Xu, Ke Liu, Hazem Hashim Ahmed et al. · Journal of Biological Chemistry | 2 Sep 2015 | 341 |
| 32 | Phosphorylation of Immunity-Related GTPases by a Toxoplasma gondii-Secreted Kinase Promotes Macrophage Survival and Virulence Sarah J. Fentress, Michael S. Behnke, Ildikò Rita Dunay et al. · Cell Host & Microbe | Dec 2010 | 336 |
| 33 | FKBP Family Proteins: Immunophilins with Versatile Biological Functions CongBao Kang, Hong Ye, Sirano Dhe‐Paganon et al. · Neurosignals | 2008 | 335 |
| 34 | Structural and biochemical studies identify tobacco SABP2 as a methyl salicylate esterase and implicate it in plant innate immunity F. Forouhar, Yue Yang, Dhirendra Kumar et al. · Proceedings of the National Academy of Sciences | 24 Jan 2005 | 332 |
| 35 | Molecular recognition of p53 and MDM2 by USP7/HAUSP Yi Sheng, V. Saridakis, Feroz Sarkari et al. · Nature Structural & Molecular Biology | 12 Feb 2006 | 321 |
| 36 | Structure and Biochemical Functions of SIRT6 Patricia W. Pan, Jessica L. Feldman, Mark Devries et al. · Journal of Biological Chemistry | 2 Mar 2011 | 320 |
| 37 | Genome-wide Analysis of Substrate Specificities of the Escherichia coli Haloacid Dehalogenase-like Phosphatase Family Ekaterina Kuznetsova, Michael Proudfoot, Claudio F. González et al. · Journal of Biological Chemistry | 21 Sep 2006 | 320 |
| 38 | Recognition and Specificity Determinants of the Human Cbx Chromodomains Lilia Kaustov, Hui Ouyang, M.F. Amaya et al. · Journal of Biological Chemistry | 3 Nov 2010 | 319 |
| 39 | Structural and Biochemical Characterization of the Human Cyclophilin Family of Peptidyl-Prolyl Isomerases Tara L. Davis, John R. Walker, Valérie Campágna‐Slater et al. · PLoS Biology | 27 Jul 2010 | 315 |
| 40 | N-myristoyltransferase inhibitors as new leads to treat sleeping sickness Julie A. Frearson et al. · Nature | 30 Mar 2010 | 315 |
| 41 | GLUT1 inhibition blocks growth of RB1-positive triple negative breast cancer Qin Wu et al. · Nature Communications | 21 Aug 2020 | 312 |
| 42 | A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases Mohammad S. Eram, Yudao Shen, Magdalena M. Szewczyk et al. · ACS Chemical Biology | 24 Nov 2015 | 304 |
| 43 | A Strategy for Modulation of Enzymes in the Ubiquitin System Andreas Ernst et al. · Science | 4 Jan 2013 | 300 |
| 44 | Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia Florian Grebien et al. · Nature Chemical Biology | 13 Jul 2015 | 295 |
| 45 | Structure of LIMP-2 provides functional insights with implications for SR-BI and CD36 Dante Neculai, Michael Schwake, Mani Ravichandran et al. · Nature | 25 Oct 2013 | 295 |
| 46 | Therapeutic Targeting of RNA Splicing Catalysis through Inhibition of Protein Arginine Methylation Jia Yi Fong et al. · Cancer Cell | Aug 2019 | 292 |
| 47 | Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors Wenyu Yu et al. · Nature Communications | 18 Dec 2012 | 292 |
| 48 | Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation Chuanbing Bian, Chao Xu, Jianbin Ruan et al. · The EMBO Journal | 17 Jun 2011 | 287 |
| 49 | Tet3 CXXC Domain and Dioxygenase Activity Cooperatively Regulate Key Genes for Xenopus Eye and Neural Development Yufei Xu et al. · Cell | Dec 2012 | 279 |
| 50 | Architecture of Eph receptor clusters Juha P. Himanen, Laila Yermekbayeva, Peter W. Janes et al. · Proceedings of the National Academy of Sciences | 26 May 2010 | 278 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.