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Topic · Statistics and Probability

Statistical Methods in Clinical Trials

Statistical Methods in Clinical Trials is a research topic within Statistics and Probability. Science Explorer counts 27k research works in it since 1950. 21.2% of them reached the world's top 10% most cited for their field and year.

This cluster of papers covers a wide range of statistical methods and design considerations in the context of clinical trials and drug development. It includes topics such as controlling the false discovery rate, adaptive trial designs, noninferiority trials, biomarkers, phase I trials, multiple testing, Bayesian methods, sample size determination, composite endpoints, and pharmacokinetic/pharmacodynamic modeling.

  • False Discovery Rate
  • Adaptive Designs
  • Noninferiority Trials
  • Biomarkers
  • Phase I Trials
  • Multiple Testing
  • Bayesian Methods
  • Sample Size
  • Composite Endpoints
  • Pharmacokinetic/Pharmacodynamic Modeling
Research works
27k
fractional, since 1950
In the world top 10%
5.8k
per year above
Top-10% rate
21.2%
share of its works in the world top 10%
Growth, 2013–17 → 2018–22
+10%
the tick is no change

Which countries lead Statistical Methods in Clinical Trials research?

By volume, the United States and the United Kingdom publish the most (1.8k and 337 works in 2022–2025).

By volume, 2022–2025

  1. 1 United States 1.8k works
  2. 2 United Kingdom 337 works
  3. 3 China 279 works
  4. 4 Germany 221 works
  5. 5 Canada 176 works
  6. 6 India 161 works
  7. 7 France 140 works
  8. 8 Japan 124 works
  9. 9 Netherlands 123 works
  10. 10 Italy 117 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

United States: 51.7%United Kingdom: 9.7%China: 8.0%Germany: 6.4%6 others listed: 24.2%52%largest
United States1,795 · 51.7%United Kingdom337 · 9.7%China279 · 8.0%Germany221 · 6.4%6 others listed841 · 24.2%

Shares of the rows listed above, not of the whole node.

Which institutions lead Statistical Methods in Clinical Trials research?

By volume in 2022–2025, University of North Carolina at Chapel Hill publishes the most Statistical Methods in Clinical Trials research, followed by Harvard University and The University of Texas MD Anderson Cancer Center.

By volume, 2022–2025

  1. 1 University of North Carolina at Chapel HillUnited States 45 works
  2. 2 Harvard UniversityUnited States 33 works
  3. 3 The University of Texas MD Anderson Cancer CenterUnited States 33 works
  4. 4 United States Food and Drug AdministrationUnited States 28 works
  5. 5 Duke UniversityUnited States 28 works
  6. 6 Pfizer (United States)United States 26 works
  7. 7 Center for Drug Evaluation and ResearchUnited States 26 works
  8. 8 University of PennsylvaniaUnited States 26 works
  9. 9 University of MichiganUnited States 24 works
  10. 10 Stanford UniversityUnited States 23 works

Who are the leading researchers in Statistical Methods in Clinical Trials?

The most-cited researchers publishing on Statistical Methods in Clinical Trials include David Moher, Douglas G. Altman and Robert Tibshirani.

  1. 1 David Moher Canada 38k citations
  2. 2 Douglas G. Altman United Kingdom 23k citations
  3. 3 Robert Tibshirani United States 13k citations
  4. 4 John P. A. Ioannidis United States 8k citations
  5. 5 Gordon Guyatt Canada 6.8k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

Where is Statistical Methods in Clinical Trials research done?

The largest centres of Statistical Methods in Clinical Trials research in 2022–2025 are London (United Kingdom), New York (United States), Beijing (China) and Cambridge (United States). Among places with at least 20 works in it, it is an unusually large share of all research in Silver Spring.

Largest cities, 2022–2025

  1. 1 London United Kingdom 119 works
  2. 2 New York United States 106 works
  3. 3 Beijing China 70 works
  4. 4 Cambridge United States 61 works
  5. 5 Boston United States 58 works
  6. 6 Silver Spring United States 57 works
  7. 7 Paris France 57 works
  8. 8 Tokyo Japan 55 works
  9. 9 Houston United States 48 works
  10. 10 Chapel Hill United States 47 works

Where it is the local speciality

  1. Silver SpringUS · 57.2 works66×
← less than its size predicts1×more →

Location quotient: how much more of its research is in Statistical Methods in Clinical Trials than the world average.

See Statistical Methods in Clinical Trials on the map

Where is the best place to study Statistical Methods in Clinical Trials?

Among universities, judged by research, Harvard University, Duke University and Medical University of Vienna score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%20%40%mean 28.36%fractional works in this node (log) →share in the world top 10% →Harvard University: 33, 32.4%Duke University: 28, 20.4%Medical University of Vienna: 8, 40.7%University College London: 22, 33.3%Stanford University: 23, 32.8%University of North Carolina at Chapel Hill: 45, 8.9%University of Pennsylvania: 26, 20.0%Yale University: 21, 28.9%University of California, San Francisco: 14, 34.8%University of Sheffield: 12, 31.4%Medical University o…University College L…Harvard UniversityDuke University
above the meannear itbelow it

One dot per university in the table below. The upper left is the interesting corner: small places doing unusually strong work.

#UniversityScoreTop 10%SpecialisationWorksGrowth
1 Harvard UniversityUnited States 58.832.4%6.4×33 +21.4%
2 Duke UniversityUnited States 56.220.4%9.7×28 +40.4%
3 Medical University of ViennaAustria 51.440.7%6.5×8 +58.8%
4 University College LondonUnited Kingdom 50.733.3%4.0×22 +54.7%
5 Stanford UniversityUnited States 49.532.8%4.6×23 +45.0%
6 University of North Carolina at Chapel HillUnited States 45.98.9%6.5×45 +92.6%
7 University of PennsylvaniaUnited States 45.120.0%6.8×26 +12.7%
8 Yale UniversityUnited States 43.628.9%5.1×21 +1.3%
9 University of California, San FranciscoUnited States 43.434.8%5.4×14 -14.0%
10 University of SheffieldUnited Kingdom 42.531.4%5.5×12 +16.9%

Universities only. Score blends excellence (30%), specialisation (25%), size (20%), growth (15%) and international reach (10%), 2015–2022; growth compares 2010–14 with 2015–19.

Is Statistical Methods in Clinical Trials research growing?

Output in 2018–2022 was 10% higher than in 2013–2017, peaking in 2025. The fastest-growing topics are Statistical Methods in Clinical Trials.

19801990200020102020
grewheldshrank

The same series as a ribbon — one cell per year, darker for more. The line above answers how much; this answers when.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.