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Topic · Ophthalmology

Drug-Induced Ocular Toxicity

Drug-Induced Ocular Toxicity is a research topic within Ophthalmology. Science Explorer counts 8k research works in it since 1950. 10.5% of them reached the world's top 10% most cited for their field and year.

This cluster of papers focuses on the ocular toxicity and retinal disorders associated with medications such as chloroquine, hydroxychloroquine, tamoxifen, and ethambutol. It covers topics such as retinopathy, maculopathy, optic neuropathy, and cardiomyopathy induced by these drugs. The papers also discuss screening guidelines, imaging techniques like multifocal electroretinography and optical coherence tomography (OCT), and the implications for rheumatology care.

  • Retinopathy
  • Chloroquine
  • Hydroxychloroquine
  • Ocular Toxicity
  • Drug-induced
  • Optic Neuropathy
  • Maculopathy
  • Screening Guidelines
  • Multifocal Electroretinography
  • OCT Imaging
Research works
8k
fractional, since 1950
In the world top 10%
838
per year above
Top-10% rate
10.5%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
-4%
the tick is no change
Largest producer
United States
35% of the 10 largest, 2022-now
Drug-Induced Ocular Toxicity

This ranks research output and citation impact. It says nothing about the quality of diagnosis, treatment or care.

Which countries lead Drug-Induced Ocular Toxicity research?

By volume, the United States and India publish the most (339 and 151 works in 2022-now).

By volume, 2022-now

  1. 1 United States 339 works
  2. 2 India 151 works
  3. 3 China 136 works
  4. 4 United Kingdom 66 works
  5. 5 France 63 works
  6. 6 Spain 48 works
  7. 7 Türkiye 48 works
  8. 8 Japan 47 works
  9. 9 Italy 41 works
  10. 10 Germany 37 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

United States: 34.7%India: 15.5%China: 13.9%United Kingdom: 6.7%6 others listed: 29.1%35%largest
United States339 · 34.7%India151 · 15.5%China136 · 13.9%United Kingdom66 · 6.7%6 others listed285 · 29.1%

Shares of the rows listed above, not of the whole node.

Which institutions lead Drug-Induced Ocular Toxicity research?

By volume in 2022-now, Harvard University publishes the most Drug-Induced Ocular Toxicity research, followed by All India Institute of Medical Sciences and University of Toronto.

By volume, 2022-now

  1. 1 Harvard UniversityUnited States 15 works
  2. 2 All India Institute of Medical SciencesIndia 12 works
  3. 3 University of TorontoCanada 10 works
  4. 4 Capital Medical UniversityChina 9 works
  5. 5 University College LondonUnited Kingdom 8 works
  6. 6 Mayo ClinicUnited States 8 works
  7. 7 United States Department of Veterans AffairsUnited States 7 works
  8. 8 Centre National de la Recherche ScientifiqueFrance 7 works
  9. 9 Hanyang UniversitySouth Korea 7 works
  10. 10 Johns Hopkins UniversityUnited States 7 works

Who are the leading researchers in Drug-Induced Ocular Toxicity?

The most-cited researchers publishing on Drug-Induced Ocular Toxicity include Jost Bruno Jonas, Hagop M. Kantarjian and Tien Yin Wong.

  1. 1 Jost Bruno Jonas Germany 350k citations
  2. 2 Hagop M. Kantarjian United States 273k citations
  3. 3 Tien Yin Wong Singapore 237k citations
  4. 4 Didier Raoult France 232k citations
  5. 5 Ronald Klein United States 214k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Drug-Induced Ocular Toxicity?

The most cited paper in Drug-Induced Ocular Toxicity is "Mechanisms of action of hydroxychloroquine and chloroquine: implications for rheumatology" (Eva Vanessa Schrezenmeier, Thomas Dörner, 2020), with 1,519 citations. Next come "Use of Arsenic Trioxide (As2O3 ) in the Treatment of Acute Promyelocytic Leukemia (APL): II. Clinical Efficacy and Pharmacokinetics in Relapsed Patients" (1,440) and "Differentiation Therapy of Acute Promyelocytic Leukemia with Tretinoin (All-trans-Retinoic Acid)" (1,287).

Most cited papers
#PaperReleasedCitations
1 Mechanisms of action of hydroxychloroquine and chloroquine: implications for rheumatology Eva Vanessa Schrezenmeier, Thomas Dörner · Nature Reviews Rheumatology Review 7 Feb 2020 1,519
2 Use of Arsenic Trioxide (As2O3 ) in the Treatment of Acute Promyelocytic Leukemia (APL): II. Clinical Efficacy and Pharmacokinetics in Relapsed Patients Zhixiang Shen, Guoqiang Chen, Jian-Hua Ni et al. · Blood May 1997 1,440
3 Differentiation Therapy of Acute Promyelocytic Leukemia with Tretinoin (All-trans-Retinoic Acid) Raymond P. Warrell, Stanley R. Frankel, Wilson H. Miller et al. · New England Journal of Medicine Open access 16 May 1991 1,287
4 Characteristics of Ocular Findings of Patients With Coronavirus Disease 2019 (COVID-19) in Hubei Province, China Ping Wu, Fang Duan, Chunhua Luo et al. · JAMA Ophthalmology Open access 31 Mar 2020 1,285
5 All-trans retinoic acid as a differentiation therapy for acute promyelocytic leukemia. I. Clinical results [see comments] Sylvie Castaigné, Christine Chomienne, MT Daniel et al. · Blood Nov 1990 1,205
All 99 most cited papers, with filters and sorting

Where is Drug-Induced Ocular Toxicity research done?

The largest centres of Drug-Induced Ocular Toxicity research in 2022-now are Beijing (China), Paris (France), London (United Kingdom) and Seoul (South Korea).

Largest cities, 2022-now

  1. 1 BeijingChina 25 works
  2. 2 ParisFrance 25 works
  3. 3 LondonUnited Kingdom 22 works
  4. 4 SeoulSouth Korea 21 works
  5. 5 New DelhiIndia 16 works
  6. 6 New YorkUnited States 16 works
  7. 7 ChennaiIndia 13 works
  8. 8 TorontoCanada 13 works
  9. 9 BostonUnited States 13 works
  10. 10 TokyoJapan 12 works
See Drug-Induced Ocular Toxicity on the map

Where is the best place to study Drug-Induced Ocular Toxicity?

Among universities, judged by research, Harvard University, University of Toronto and Capital Medical University score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%10%20%mean 15.9%fractional works in this field (log) →share of work in the world top 10% →Capital Medical Univ…Harvard UniversityUniversity of TorontoUniversity College L…
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Harvard UniversityUnited States 80.817.2%3.8×15 -3.4%
2University of TorontoCanada 61.217.0%4.1×10 +18.1%
3Capital Medical UniversityChina 60.123.2%6.8×9 +52.4%
4University College LondonUnited Kingdom 49.516.4%4.1×8 +16.8%
5All India Institute of Medical SciencesIndia 38.85.7%8.7×12 +53.5%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Drug-Induced Ocular Toxicity, country by country

Is Drug-Induced Ocular Toxicity research growing?

Output in 2022-2025 was 4% lower than in 2018-2021, peaking in 2020.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Drug-Induced Ocular Toxicity as a percentage of every work published that year, 0.0056% in 2024.

still counting0.0050%0.010%0.015%Drug-Induced Ocular Toxicity0.0059% in 202519801990200020102020

Fractional works of Drug-Induced Ocular Toxicity over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Drug-Induced Ocular Toxicity10.7% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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