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Company · Boston · United States

Vertex Pharmaceuticals (United States)

In research, Vertex Pharmaceuticals (United States) stands highest in Health Sciences (#2,846 of 9,902 worldwide) and Medicine (#3,024 of 8,541 worldwide), 2022-now.

vrtx.comROR OpenAlex
World rank, 2022-now
#7,406
of 22,385 · #2,538 all time
Rank in United States
#990
of 3,332
Research works
1.2k
▲ 16% vs 2018-21
Citations
68k
57.1 per fractional work
Top-10% rate
14.5%
all institutions 10.0%
vs its own fields
1.01×
1.00× is exactly expected
Open access
37%
world 40%
International
22%
world 18%
Vertex Pharmaceuticals (United States)

What is Vertex Pharmaceuticals (United States) known for in research?

The fields where it stands highest, 2022-now, ranked among every institution above the floor in each field.

FieldWorld rankWhere that sitsTop-10% rateWorksAll time
Health SciencesDomain #2,846 of 9,902 18.7%85 #2186
MedicineField #3,024 of 8,541 17.6%81 #2119

Each strip is that field's whole ranked pool, with the notch where Vertex Pharmaceuticals (United States) sits in it, in the colour of the band that rank falls in. The track under the rate is the rate itself: it carries no average mark, because the average differs by field (from about 6% in Dentistry to 21% in Economics).

Which fields of science does Vertex Pharmaceuticals (United States) work in?

In 2022-now, 53% of research at Vertex Pharmaceuticals (United States) is in Health Sciences, 23% in Physical Sciences. Its largest fields are Medicine (50%), Biochemistry, Genetics and Molecular Biology (12%), Engineering (7%). It does 2.2× the world's share of Health Sciences.

Health Sciences: 99 fractional works · 52.7% of its workMedicine: 94 fractional works · 50.0% of its workGenetics: 19 fractional works · 10.1% of its workPulmonary and Respiratory Medicine: 16 fractional works · 8.7% of its workHematology: 11 fractional works · 5.7% of its workNephrology: 6 fractional works · 3.0% of its workEndocrinology, Diabetes and Metabolism: 5 fractional works · 2.8% of its workCardiology and Cardiovascular Medicine: 4 fractional works · 2.0% of its workEpidemiology: 3 fractional works · 1.8% of its workPhysiology: 3 fractional works · 1.8% of its workPublic Health, Environmental and Occupational Health: 3 fractional works · 1.8% of its workOncology: 3 fractional works · 1.7% of its workPharmacology: 3 fractional works · 1.5% of its workPediatrics, Perinatology and Child Health: 3 fractional works · 1.4% of its workSurgery: 2 fractional works · 1.3% of its workRheumatology: 2 fractional works · 1.1% of its workInfectious Diseases: 2 fractional works · 0.9% of its workPsychiatry and Mental health: 1 fractional works · 0.7% of its workRadiology, Nuclear Medicine and Imaging: 1 fractional works · 0.6% of its workAnesthesiology and Pain Medicine: 1 fractional works · 0.6% of its workPathology and Forensic Medicine: 1 fractional works · 0.4% of its workOrthopedics and Sports Medicine: 1 fractional works · 0.4% of its workBiochemistry: 0 fractional works · 0.2% of its workEmergency Medicine: 0 fractional works · 0.2% of its workDermatology: 0 fractional works · 0.2% of its workSmaller subfields together: 2 fractional works · 1.1% of its workHealth Professions: 5 fractional works · 2.4% of its workEmergency Medical Services: 2 fractional works · 1.1% of its workGeneral Health Professions: 1 fractional works · 0.8% of its workSmaller subfields together: 1 fractional works · 0.5% of its workVeterinary: 0 fractional works · 0.2% of its workDentistry: 0 fractional works · 0.1% of its workPhysical Sciences: 43 fractional works · 23.0% of its workEngineering: 13 fractional works · 6.8% of its workBiomedical Engineering: 3 fractional works · 1.7% of its workMechanical Engineering: 2 fractional works · 0.9% of its workElectrical and Electronic Engineering: 1 fractional works · 0.7% of its workCivil and Structural Engineering: 1 fractional works · 0.6% of its workOcean Engineering: 1 fractional works · 0.5% of its workComputational Mechanics: 1 fractional works · 0.4% of its workAerospace Engineering: 1 fractional works · 0.4% of its workSafety, Risk, Reliability and Quality: 1 fractional works · 0.4% of its workIndustrial and Manufacturing Engineering: 1 fractional works · 0.3% of its workControl and Systems Engineering: 1 fractional works · 0.3% of its workMechanics of Materials: 1 fractional works · 0.3% of its workSmaller subfields together: 1 fractional works · 0.3% of its workChemistry: 9 fractional works · 4.8% of its workOrganic Chemistry: 4 fractional works · 2.3% of its workSpectroscopy: 2 fractional works · 0.9% of its workAnalytical Chemistry: 2 fractional works · 0.8% of its workPhysical and Theoretical Chemistry: 1 fractional works · 0.5% of its workInorganic Chemistry: 1 fractional works · 0.3% of its workComputer Science: 8 fractional works · 4.0% of its workArtificial Intelligence: 3 fractional works · 1.6% of its workInformation Systems: 1 fractional works · 0.7% of its workComputer Networks and Communications: 1 fractional works · 0.6% of its workComputer Vision and Pattern Recognition: 1 fractional works · 0.5% of its workComputational Theory and Mathematics: 1 fractional works · 0.4% of its workSmaller subfields together: 0 fractional works · 0.2% of its workMathematics: 7 fractional works · 3.7% of its workStatistics and Probability: 6 fractional works · 3.3% of its workSmaller subfields together: 1 fractional works · 0.4% of its workEnvironmental Science: 3 fractional works · 1.7% of its workEnvironmental Chemistry: 1 fractional works · 0.7% of its workEnvironmental Engineering: 0 fractional works · 0.3% of its workManagement, Monitoring, Policy and Law: 0 fractional works · 0.2% of its workSmaller subfields together: 1 fractional works · 0.5% of its workMaterials Science: 3 fractional works · 1.4% of its workMaterials Chemistry: 2 fractional works · 1.1% of its workSmaller subfields together: 0 fractional works · 0.3% of its workPhysics and Astronomy: 1 fractional works · 0.7% of its workNuclear and High Energy Physics: 0 fractional works · 0.2% of its workSmaller subfields together: 1 fractional works · 0.4% of its workChemical Engineering: 0 fractional works · 0.0% of its workLife Sciences: 33 fractional works · 17.5% of its workBiochemistry, Genetics and Molecular Biology: 23 fractional works · 12.3% of its workMolecular Biology: 15 fractional works · 8.0% of its workGenetics: 3 fractional works · 1.7% of its workCancer Research: 2 fractional works · 0.8% of its workBiophysics: 1 fractional works · 0.6% of its workCell Biology: 1 fractional works · 0.4% of its workSmaller subfields together: 1 fractional works · 0.7% of its workImmunology and Microbiology: 4 fractional works · 1.9% of its workImmunology: 3 fractional works · 1.9% of its workSmaller subfields together: 0 fractional works · 0.0% of its workPharmacology, Toxicology and Pharmaceutics: 3 fractional works · 1.7% of its workPharmaceutical Science: 2 fractional works · 1.1% of its workPharmacology: 1 fractional works · 0.4% of its workToxicology: 0 fractional works · 0.3% of its workNeuroscience: 2 fractional works · 1.1% of its workCellular and Molecular Neuroscience: 1 fractional works · 0.8% of its workSmaller subfields together: 1 fractional works · 0.4% of its workAgricultural and Biological Sciences: 1 fractional works · 0.4% of its workSocial Sciences: 13 fractional works · 6.9% of its workSocial Sciences: 5 fractional works · 2.8% of its workSociology and Political Science: 5 fractional works · 2.5% of its workSmaller subfields together: 1 fractional works · 0.3% of its workEconomics, Econometrics and Finance: 4 fractional works · 2.2% of its workEconomics and Econometrics: 4 fractional works · 2.0% of its workFinance: 0 fractional works · 0.2% of its workDecision Sciences: 1 fractional works · 0.8% of its workManagement Science and Operations Research: 1 fractional works · 0.5% of its workSmaller subfields together: 0 fractional works · 0.2% of its workPsychology: 1 fractional works · 0.7% of its workSocial Psychology: 1 fractional works · 0.4% of its workSmaller subfields together: 1 fractional works · 0.4% of its workBusiness, Management and Accounting: 1 fractional works · 0.4% of its workArts and Humanities: 0 fractional works · 0.0% of its workALL ITS WORKVertexPharmaceuticals…188fractional works, 2022-now
Life Sciences17%Physical Sciences23%Health Sciences53%Social Sciences7%

Each ring splits the one inside it: the four domains of science, their fields, their subfields. Size is fractional works in 2022-now. Every slice is a page; the interactive view zooms down to single topics and colours each by how much more of it this institution does than the world.

Its 4 domains and 24 fields, with their numbers
    1. Medicine9450.0%
    2. Health Professions52.4%
    3. Veterinary00.2%
    4. Dentistry00.1%
    5. Nursing00.0%
    1. Engineering136.8%
    2. Chemistry94.8%
    3. Computer Science84.0%
    4. Mathematics73.7%
    5. Environmental Science31.7%
    6. Materials Science31.4%
    7. Physics and Astronomy10.7%
    8. Chemical Engineering00.0%
    1. Biochemistry, Genetics and Molecular Biology2312.3%
    2. Immunology and Microbiology41.9%
    3. Pharmacology, Toxicology and Pharmaceutics31.7%
    4. Neuroscience21.1%
    5. Agricultural and Biological Sciences10.4%
    1. Social Sciences52.8%
    2. Economics, Econometrics and Finance42.2%
    3. Decision Sciences10.8%
    4. Psychology10.7%
    5. Business, Management and Accounting10.4%
    6. Arts and Humanities00.0%
All of science, and how each field's share has moved since 1950: the Science domain explorer

Field profile

Location quotient across every field it publishes in: outside the ring is more than an institution of this size would be expected to publish, inside it is less.

Agricultural and Biological Sciences: 0.09× its world share, 1 worksAgricultural and Bio…Biochemistry, Genetics and Molecular Biology: 2.30× its world share, 23 worksBiochemistry, Geneti…Immunology and Microbiology: 1.87× its world share, 4 worksImmunology and Micro…Neuroscience: 0.71× its world share, 2 worksNeurosciencePharmacology, Toxicology and Pharmaceutics: 4.96× its world share, 3 worksPharmacology, Toxico…Chemical Engineering: 0.10× its world share, 0 worksChemical EngineeringChemistry: 3.05× its world share, 9 worksChemistryComputer Science: 0.52× its world share, 8 worksComputer ScienceEngineering: 0.45× its world share, 13 worksEngineeringEnvironmental Science: 0.33× its world share, 3 worksEnvironmental ScienceMaterials Science: 0.40× its world share, 3 worksMaterials ScienceMathematics: 3.11× its world share, 7 worksMathematicsPhysics and Astronomy: 0.29× its world share, 1 worksPhysics and AstronomyDentistry: 0.21× its world share, 0 worksDentistryHealth Professions: 0.91× its world share, 4 worksHealth ProfessionsMedicine: 2.60× its world share, 94 worksMedicineNursing: 0.02× its world share, 0 worksNursingVeterinary: 1.29× its world share, 0 worksVeterinaryArts and Humanities: 0.01× its world share, 0 worksArts and HumanitiesBusiness, Management and Accounting: 0.11× its world share, 1 worksBusiness, Management…Decision Sciences: 0.79× its world share, 1 worksDecision SciencesEconomics, Econometrics and Finance: 1.04× its world share, 4 worksEconomics, Econometr…Psychology: 0.24× its world share, 1 worksPsychologySocial Sciences: 0.22× its world share, 5 worksSocial Sciences1×world share
more than its size predictsabout as predictedless

Rings at 0.5×, 1× and 2×. Widest outward: Pharmacology, Toxicology and Pharmaceutics, 5.0×. Every wedge is a field page.

All 24 fields, with their numbers
  1. Pharmacology, Toxicology and Pharmaceutics4.96×3 works
  2. Mathematics3.11×7 works
  3. Chemistry3.05×9 works
  4. Medicine2.60×94 works
  5. Biochemistry, Genetics and Molecular Biology2.30×23 works
  6. Immunology and Microbiology1.87×4 works
  7. Veterinary1.29×0 works
  8. Economics, Econometrics and Finance1.04×4 works
  9. Health Professions0.91×4 works
  10. Decision Sciences0.79×1 works
  11. Neuroscience0.71×2 works
  12. Computer Science0.52×8 works
  13. Engineering0.45×13 works
  14. Materials Science0.40×3 works
  15. Environmental Science0.33×3 works
  16. Physics and Astronomy0.29×1 works
  17. Psychology0.24×1 works
  18. Social Sciences0.22×5 works
  19. Dentistry0.21×0 works
  20. Business, Management and Accounting0.11×1 works
  21. Chemical Engineering0.10×0 works
  22. Agricultural and Biological Sciences0.09×1 works
  23. Nursing0.02×0 works
  24. Arts and Humanities0.01×0 works

Who are the top researchers at Vertex Pharmaceuticals (United States)?

Ranked on the quality score, Mark A. Murcko, Simon Tian and Ann D. Kwong lead among researchers whose main affiliation is Vertex Pharmaceuticals (United States).

  1. 1 Mark A. Murcko United States · #31,517 worldwide 17k citations · 118 works
  2. 2 Simon Tian United States · #60,420 worldwide 5.9k citations · 52 works
  3. 3 Ann D. Kwong United States · #85,516 worldwide 8.9k citations · 88 works
  4. 4 Keisuke Kuida United States · #88,458 worldwide 18k citations · 119 works
  5. 5 Neil Ahluwalia United States · #107,980 worldwide 4.4k citations · 59 works
  6. 6 Gautham Marigowda United States · #126,723 worldwide 9k citations · 40 works
  7. 7 David J. Livingston United States · #167,288 worldwide 10k citations · 64 works
  8. 8 Lora L. Swenson United States · #174,790 worldwide 4.1k citations · 40 works
  9. 9 David A. Pearlman United States · #183,178 worldwide 8.2k citations · 68 works
  10. 10 Keith P. Wilson United States · #189,766 worldwide 5.7k citations · 92 works
All ranked researchers at Vertex Pharmaceuticals (United States)

What are the most cited papers from Vertex Pharmaceuticals (United States)?

The most cited paper from Vertex Pharmaceuticals (United States) is "A global reference for human genetic variation" (Corresponding authors et al., 2015), with 20,444 citations. Next come "Analysis of protein-coding genetic variation in 60,706 humans" (10,439) and "The mutational constraint spectrum quantified from variation in 141,456 humans" (10,422).

Most cited papers
#PaperReleasedCitations
1 A global reference for human genetic variation Corresponding authors et al. · Nature Open access815 authors 29 Sep 2015 20,444
2 Analysis of protein-coding genetic variation in 60,706 humans Monkol Lek et al. · Nature Open access Aug 2016 10,439
3 The mutational constraint spectrum quantified from variation in 141,456 humans Konrad J. Karczewski et al. · Nature Open access177 authors 27 May 2020 10,422
4 A reference panel of 64,976 haplotypes for genotype imputation Shane McCarthy et al. · Nature Genetics Open access111 authors 22 Aug 2016 3,318
5 AMBER, a package of computer programs for applying molecular mechanics, normal mode analysis, molecular dynamics and free energy calculations to simulate the structural and energetic properties of molecules David A. Pearlman, David Andrew Case, James W. Caldwell et al. · Computer Physics Communications Sep 1995 3,156
All 59 most cited papers, with filters and sorting

Which keywords describe research at Vertex Pharmaceuticals (United States)?

By fractional works in 2022-now, weighted toward what it does more of than the world: Pulmonary Hypertension, Genetic Regulation, Sickle-cell Disease, Thalassemia, Epidemiology, Cystic Fibrosis, Pulmonary Infections and Bronchiectasis.

▲ more of its work than of the world's◆ about the world's share▼ less than the world's

Size is fractional works in 2022-now in the topics tagged with each word; colour is the word's share of this institution's work against its share of the world's. The 40 words are chosen for being large and distinctive. Each links to the topic it comes from most.

All 40 words, with their numbers
  1. Epidemiology24▲ 3.2×28 topics
  2. Pulmonary Hypertension18▲ 68×3 topics
  3. Genetic Regulation17▲ 55×3 topics
  4. Sickle-cell Disease17▲ 216×1 topic
  5. Thalassemia17▲ 216×1 topic
  6. Cystic Fibrosis13▲ 96×2 topics
  7. Pulmonary Infections12▲ 109×2 topics
  8. Bronchiectasis12▲ 227×1 topic
  9. CFTR12▲ 227×1 topic
  10. Inflammation9▲ 2.2×31 topics
  11. Cardiovascular Disease7▲ 3.3×15 topics
  12. Anemia7▲ 36×4 topics
  13. Quality of Life6▲ 2.1×9 topics
  14. Oxidative Stress6▲ 1.80×19 topics
  15. Glycemic Control5▲ 15×4 topics
  16. Diabetes4▲ 4.5×7 topics
  17. Biomarkers4▲ 3.2×9 topics
  18. Glomerular Diseases4▲ 63×1 topic
  19. Insulin Therapy4▲ 16×3 topics
  20. Nephrotic Syndrome4▲ 63×1 topic
  21. Type 1 Diabetes4▲ 24×2 topics
  22. Bayesian Methods4▲ 38×2 topics
  23. Hematopoietic Stem Cells4▲ 21×3 topics
  24. Iron Deficiency3▲ 35×2 topics
  25. Prognostic Factors3▲ 4.2×5 topics
  26. Hepcidin3▲ 43×1 topic
  27. Iron Regulation3▲ 43×1 topic
  28. Continuous Glucose Monitoring3▲ 33×1 topic
  29. Drug Discovery3▲ 6.8×6 topics
  30. Health Promotion3▲ 4.8×4 topics
  31. Hypoglycemia3▲ 33×1 topic
  32. Pancreatic Cancer3▲ 14×2 topics
  33. Adaptive Designs3▲ 70×1 topic
  34. Alloimmunization3▲ 59×1 topic
  35. Blood Groups3▲ 59×1 topic
  36. False Discovery Rate3▲ 70×1 topic
  37. Chronic Pain2▲ 5.9×5 topics
  38. Economic Evaluation2▲ 9.8×2 topics
  39. Cost-effectiveness Analysis2▲ 14×1 topic
  40. Health Utility Measures2▲ 14×1 topic

Which research topics does Vertex Pharmaceuticals (United States) publish most on?

By volume in 2022-now: Hemoglobinopathies and Related Disorders, Cystic Fibrosis Research Advances, Renal Diseases and Glomerulopathies and Iron Metabolism and Disorders.

Hemoglobinopathies and R…17Hemoglobinopathies and Related Disorders: 17 fractional worksCystic Fibrosis Research…12Cystic Fibrosis Research Advances: 12 fractional worksRenal Diseases and Glomerulopathies: 4 fractional worksIron Metabolism and Disorders: 3 fractional worksDiabetes Management and Research: 3 fractional worksBlood groups and transfusion: 3 fractional worksStatistical Methods in Clinical Trials: 3 fractional worksHealth Systems, Economic Evaluations, Quality of Life: 2 fractional worksPediatric health and respiratory diseases: 2 fractional worksAcute Myeloid Leukemia Research: 2 fractional works
GeneticsPulmonary and Respiratory MedicineNephrologyHematology4 others

Area is fractional works; colour is the subfield each topic belongs to.

  1. 1 Hemoglobinopathies and Related Disorders Genetics 17 works
  2. 2 Cystic Fibrosis Research Advances Pulmonary and Respiratory Medicine 12 works
  3. 3 Renal Diseases and Glomerulopathies Nephrology 4 works
  4. 4 Iron Metabolism and Disorders Hematology 3 works
  5. 5 Diabetes Management and Research Endocrinology, Diabetes and Metabolism 3 works
  6. 6 Blood groups and transfusion Hematology 3 works
  7. 7 Statistical Methods in Clinical Trials Statistics and Probability 3 works
  8. 8 Health Systems, Economic Evaluations, Quality of Life Economics and Econometrics 2 works
  9. 9 Pediatric health and respiratory diseases Emergency Medical Services 2 works
  10. 10 Acute Myeloid Leukemia Research Hematology 2 works

How open and international is its research?

Against the world's own shares: the tick on each track. Both are shares of its output, so they sit on one scale and can be read against each other as well as against the world.

openly available36.7%not open63.3%

World: 40% of research is openly available.

with international co-authors21.6%domestic only78.4%

World: 18% is written across borders.

How has Vertex Pharmaceuticals (United States)'s research output changed?

Output in 2022-2025 was 16% higher than in 2018-2021.

still counting1990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Vertex Pharmaceuticals (United States) as a percentage of every work published that year, 0.00081% in 2024.

still counting0.0010%0.0020%0.0030%Vertex Pharmaceuticals (United States)0.00076% in 20251990200020102020

Fractional works of Vertex Pharmaceuticals (United States) over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year, against all institutions in the same year.

still counting20%40%Vertex Pharmaceuticals (United States)16.7% in 2025all institutions10.0% in 2025200020102020

Of each year's output, the share that reached the world's 10% most cited for its field and year. Peak 31.5% in 1995.

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Vertex Pharmaceuticals (United States) on Science Explorer

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