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Topic · Hematology

Iron Metabolism and Disorders

Iron Metabolism and Disorders is a research topic within Hematology. Science Explorer counts 47k research works in it since 1950. 10.1% of them reached the world's top 10% most cited for their field and year.

This cluster of papers focuses on the regulation of iron metabolism, including the role of hepcidin, ferroportin, and transferrin in maintaining iron homeostasis. It also explores the impact of inflammation, anemia, and oxidative stress on iron levels, as well as the association between iron deficiency and conditions such as hemochromatosis.

  • Hepcidin
  • Iron Regulation
  • Anemia
  • Ferroportin
  • Iron Deficiency
  • Inflammation
  • Erythropoiesis
  • Transferrin
  • Oxidative Stress
  • Hemochromatosis
Research works
47k
fractional, since 1950
In the world top 10%
4.7k
per year above
Top-10% rate
10.1%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
+17%
the tick is no change
Largest producer
United States
28% of the 10 largest, 2022-now
Iron Metabolism and Disorders

This ranks research output and citation impact. It says nothing about the quality of diagnosis, treatment or care.

Which countries lead Iron Metabolism and Disorders research?

By volume, the United States and China publish the most (1.6k and 1k works in 2022-now).

By volume, 2022-now

  1. 1 United States 1.6k works
  2. 2 China 1k works
  3. 3 India 968 works
  4. 4 Brazil 530 works
  5. 5 Indonesia 498 works
  6. 6 United Kingdom 324 works
  7. 7 Pakistan 277 works
  8. 8 Italy 188 works
  9. 9 Japan 184 works
  10. 10 Ethiopia 173 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

United States: 28.2%China: 17.4%India: 16.8%Brazil: 9.2%6 others listed: 28.5%28%largest
United States1,631 · 28.2%China1,003 · 17.4%India968 · 16.8%Brazil530 · 9.2%6 others listed1,643 · 28.5%

Shares of the rows listed above, not of the whole node.

Which institutions lead Iron Metabolism and Disorders research?

By volume in 2022-now, All India Institute of Medical Sciences publishes the most Iron Metabolism and Disorders research, followed by Harvard University and University of Toronto.

By volume, 2022-now

  1. 1 All India Institute of Medical SciencesIndia 56 works
  2. 2 Harvard UniversityUnited States 44 works
  3. 3 University of TorontoCanada 37 works
  4. 4 Banaras Hindu UniversityIndia 35 works
  5. 5 Johns Hopkins UniversityUnited States 32 works
  6. 6 Emory UniversityUnited States 30 works
  7. 7 Indian Council of Medical ResearchIndia 29 works
  8. 8 Airlangga UniversityIndonesia 28 works
  9. 9 University of North Carolina at Chapel HillUnited States 28 works
  10. 10 University of GondarEthiopia 27 works

Who are the leading researchers in Iron Metabolism and Disorders?

The most-cited researchers publishing on Iron Metabolism and Disorders include Christopher J L Murray, Simon Iain Hay and George Davey Smith.

  1. 1 Christopher J L Murray United States 583k citations
  2. 2 Simon Iain Hay United States 452k citations
  3. 3 George Davey Smith United Kingdom 435k citations
  4. 4 Ali H. Mokdad United States 429k citations
  5. 5 Walter Churchill Willett United States 411k citations
  6. 6 Mark J. Daly United States 403k citations
  7. 7 Guido Kroemer France 386k citations
  8. 8 Zulfiqar Ahmed Bhutta Pakistan 371k citations
  9. 9 Jost Bruno Jonas Germany 350k citations
  10. 10 John J.V. McMurray United Kingdom 349k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Iron Metabolism and Disorders?

The most cited paper in Iron Metabolism and Disorders is "The Ferric Reducing Ability of Plasma (FRAP) as a Measure of “Antioxidant Power”: The FRAP Assay" (Iris F. F. Benzie, JJ Strain, 1996), with 23,032 citations. Next come "Maternal and child undernutrition: global and regional exposures and health consequences" (6,557) and "Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization" (4,836).

Most cited papers
#PaperReleasedCitations
1 The Ferric Reducing Ability of Plasma (FRAP) as a Measure of “Antioxidant Power”: The FRAP Assay Iris F. F. Benzie, JJ Strain · Analytical Biochemistry Jul 1996 23,032
2 Maternal and child undernutrition: global and regional exposures and health consequences Robert E. Black, Lindsay Helen Allen, Zulfiqar Ahmed Bhutta et al. · The Lancet 2008 6,557
3 Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization Elizabeta Nemeth, Marie S. Tuttle, Julie Powelson et al. · Science 28 Oct 2004 4,836
4 Targeting Hypoxia-Inducible Factors for the Treatment of Anemia in Chronic Kidney Disease Patients Francesco Locatelli, Steven N. Fishbane, Geoffrey A. Block et al. · American Journal of Nephrology Open access 2017 4,818
5 Anemia of Chronic Disease Günter Weiß, Lawrence T. Goodnough · New England Journal of Medicine 9 Mar 2005 3,793
All 98 most cited papers, with filters and sorting

Where is Iron Metabolism and Disorders research done?

The largest centres of Iron Metabolism and Disorders research in 2022-now are Beijing (China), London (United Kingdom), São Paulo (Brazil) and New Delhi (India). Among places with at least 20 works in it, it is an unusually large share of all research in Gonder.

Largest cities, 2022-now

  1. 1 BeijingChina 145 works
  2. 2 LondonUnited Kingdom 106 works
  3. 3 São PauloBrazil 99 works
  4. 4 New DelhiIndia 93 works
  5. 5 New YorkUnited States 79 works
  6. 6 ParisFrance 71 works
  7. 7 DhakaBangladesh 63 works
  8. 8 JakartaIndonesia 63 works
  9. 9 ShanghaiChina 59 works
  10. 10 LahorePakistan 56 works

Where it is the local speciality

  1. GonderET · 27.0 works20×
← less than its size predicts1×more →

Location quotient: how much more of its research is in Iron Metabolism and Disorders than the world average.

See Iron Metabolism and Disorders on the map

Where is the best place to study Iron Metabolism and Disorders?

Among universities, judged by research, University of Gondar, University of Toronto and Zhejiang University score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%20%40%mean 23.56%fractional works in this field (log) →share of work in the world top 10% →Zhejiang UniversityOregon Health & Scie…University of TorontoUniversity of Gondar
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1University of GondarEthiopia 68.919.5%23.0×27 +50.0%
2University of TorontoCanada 63.921.8%2.3×37 +11.5%
3Zhejiang UniversityChina 61.735.9%1.1×24 +5.0%
4Oregon Health & Science UniversityUnited States 60.428.7%5.9×16 +80.8%
5Wollo UniversityEthiopia 59.528.9%19.4×9 +328.4%
6Kampala International UniversityUganda 59.124.2%26.0×15 -
7China Medical UniversityChina 58.943.4%2.7×9 +47.5%
8Harvard UniversityUnited States 58.515.8%1.7×44 -13.5%
9Emory UniversityUnited States 56.912.3%4.6×30 +27.0%
10All India Institute of Medical SciencesIndia 55.75.1%6.3×56 +45.1%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Iron Metabolism and Disorders, country by country

Is Iron Metabolism and Disorders research growing?

Output in 2022-2025 was 17% higher than in 2018-2021, peaking in 2025. The fastest-growing topics are Iron Metabolism and Disorders.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Iron Metabolism and Disorders as a percentage of every work published that year, 0.038% in 2024.

still counting0.025%0.050%0.075%Iron Metabolism and Disorders0.038% in 202519801990200020102020

Fractional works of Iron Metabolism and Disorders over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Iron Metabolism and Disorders10.5% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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