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Topic · Hematology

Autoimmune and Inflammatory Disorders Research

Autoimmune and Inflammatory Disorders Research is a research topic within Hematology. Science Explorer counts 24k research works in it since 1950. 10.2% of them reached the world's top 10% most cited for their field and year.

This cluster of papers focuses on hemophagocytic syndromes, particularly hemophagocytic lymphohistiocytosis (HLH) and related disorders such as macrophage activation syndrome. It covers topics including diagnostic guidelines, therapeutic approaches, genetic mutations, cytokine involvement, and treatment efficacy in both pediatric and adult patients with various forms of the syndrome. The cluster also explores the association of these syndromes with conditions like juvenile idiopathic arthritis and provides insights into the pathogenesis, classification criteria, and long-term outcomes.

  • Hemophagocytic Lymphohistiocytosis
  • Juvenile Idiopathic Arthritis
  • Macrophage Activation Syndrome
  • Cytotoxic Granules Fusion
  • Interleukin-1 Blockade
  • Perforin Gene Mutations
  • Systemic-onset Juvenile Idiopathic Arthritis
  • Etoposide Treatment
  • Familial Hemophagocytic Lymphohistiocytosis
  • HLH-2004 Guidelines
Research works
24k
fractional, since 1950
In the world top 10%
2.5k
per year above
Top-10% rate
10.2%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
+2%
the tick is no change
Largest producer
United States
26% of the 10 largest, 2022-now
Autoimmune and Inflammatory Disorders Research

This ranks research output and citation impact. It says nothing about the quality of diagnosis, treatment or care.

Which countries lead Autoimmune and Inflammatory Disorders Research research?

By volume, the United States and China publish the most (979 and 762 works in 2022-now).

By volume, 2022-now

  1. 1 United States 979 works
  2. 2 China 762 works
  3. 3 United Kingdom 339 works
  4. 4 India 303 works
  5. 5 Türkiye 274 works
  6. 6 Japan 246 works
  7. 7 Italy 245 works
  8. 8 Germany 207 works
  9. 9 France 200 works
  10. 10 Brazil 165 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

United States: 26.3%China: 20.5%United Kingdom: 9.1%India: 8.1%6 others listed: 35.9%26%largest
United States979 · 26.3%China762 · 20.5%United Kingdom339 · 9.1%India303 · 8.1%6 others listed1,337 · 35.9%

Shares of the rows listed above, not of the whole node.

Which institutions lead Autoimmune and Inflammatory Disorders Research research?

By volume in 2022-now, Capital Medical University publishes the most Autoimmune and Inflammatory Disorders Research research, followed by Harvard University and University College London.

By volume, 2022-now

  1. 1 Capital Medical UniversityChina 43 works
  2. 2 Harvard UniversityUnited States 42 works
  3. 3 University College LondonUnited Kingdom 32 works
  4. 4 Sichuan UniversityChina 31 works
  5. 5 University of CincinnatiUnited States 30 works
  6. 6 Shanghai Jiao Tong UniversityChina 30 works
  7. 7 All India Institute of Medical SciencesIndia 28 works
  8. 8 Hacettepe UniversityTürkiye 26 works
  9. 9 University of TorontoCanada 26 works
  10. 10 InsermFrance 25 works

Who are the leading researchers in Autoimmune and Inflammatory Disorders Research?

The most-cited researchers publishing on Autoimmune and Inflammatory Disorders Research include Mark J. Daly, Shizuo Akira and Cyrus Cooper.

  1. 1 Mark J. Daly United States 403k citations
  2. 2 Shizuo Akira Japan 342k citations
  3. 3 Cyrus Cooper United Kingdom 342k citations
  4. 4 Gordon Henry Guyatt Canada 315k citations
  5. 5 Elie A. Akl Canada 313k citations
  6. 6 Richard A. Gibbs United States 292k citations
  7. 7 Hagop M. Kantarjian United States 273k citations
  8. 8 Charles M. Perou United States 263k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Autoimmune and Inflammatory Disorders Research?

The most cited paper in Autoimmune and Inflammatory Disorders Research is "COVID-19: consider cytokine storm syndromes and immunosuppression" (Puja Mehta, Daniel Francis McAuley, Michael Brown et al., 2020), with 10,244 citations. Next come "Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death" (6,817) and "EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2016 update" (5,808).

Most cited papers
#PaperReleasedCitations
1 COVID-19: consider cytokine storm syndromes and immunosuppression Puja Mehta, Daniel Francis McAuley, Michael Brown et al. · The Lancet Open access Mar 2020 10,244
2 Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death Jianjin Shi, Yue Zhao, Kun Wang et al. · Nature 16 Sep 2015 6,817
3 EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2016 update Josef S Smolen et al. · Annals of the Rheumatic Diseases Open access 6 Mar 2017 5,808
4 HLH‐2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis Jan‐Inge Henter, AnnaCarin Horne, Maurizio Aricò et al. · Pediatric Blood & Cancer 25 Aug 2006 5,452
5 IL-6 in Inflammation, Immunity, and Disease Toshio Tanaka, Masashi Narazaki, Tadamitsu Kishimoto · Cold Spring Harbor Perspectives in Biology Open access 4 Sep 2014 5,134
All 100 most cited papers, with filters and sorting

Where is Autoimmune and Inflammatory Disorders Research research done?

The largest centres of Autoimmune and Inflammatory Disorders Research research in 2022-now are Beijing (China), London (United Kingdom), Paris (France) and Istanbul (Türkiye). Among places with at least 20 works in it, it is an unusually large share of all research in Tunis and Cincinnati.

Largest cities, 2022-now

  1. 1 BeijingChina 121 works
  2. 2 LondonUnited Kingdom 101 works
  3. 3 ParisFrance 83 works
  4. 4 IstanbulTürkiye 83 works
  5. 5 TokyoJapan 71 works
  6. 6 AnkaraTürkiye 69 works
  7. 7 ShanghaiChina 60 works
  8. 8 MoscowRussia 54 works
  9. 9 RomeItaly 48 works
  10. 10 New YorkUnited States 47 works

Where it is the local speciality

  1. TunisTN · 28.3 works7.7×
  2. CincinnatiUS · 30.9 works7.2×
← less than its size predicts1×more →

Location quotient: how much more of its research is in Autoimmune and Inflammatory Disorders Research than the world average.

See Autoimmune and Inflammatory Disorders Research on the map

Where is the best place to study Autoimmune and Inflammatory Disorders Research?

Among universities, judged by research, Harvard University, Shanghai Jiao Tong University and Zhejiang University score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%10%20%30%mean 17.31%fractional works in this field (log) →share of work in the world top 10% →Harvard UniversityShanghai Jiao Tong U…Zhejiang UniversitySichuan University
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Harvard UniversityUnited States 79.121.0%2.7×42 +5.5%
2Shanghai Jiao Tong UniversityChina 65.620.8%2.1×30 +29.3%
3Zhejiang UniversityChina 63.019.5%1.9×25 +41.6%
4Sichuan UniversityChina 62.414.8%2.8×31 +107.7%
5University of CincinnatiUnited States 62.29.7%10.5×30 -4.9%
6Capital Medical UniversityChina 59.46.7%8.2×43 +28.4%
7University of LeedsUnited Kingdom 58.927.6%4.4×12 -34.4%
8University College LondonUnited Kingdom 57.510.5%4.1×32 -12.2%
9Soochow UniversityChina 57.422.1%2.9×14 +120.4%
10Karolinska InstitutetSweden 56.820.4%5.3×14 -19.8%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Autoimmune and Inflammatory Disorders Research, country by country

Is Autoimmune and Inflammatory Disorders Research research growing?

Output in 2022-2025 was 2% higher than in 2018-2021, peaking in 2021. The fastest-growing topics are Autoimmune and Inflammatory Disorders Research.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Autoimmune and Inflammatory Disorders Research as a percentage of every work published that year, 0.022% in 2024.

still counting0.010%0.020%0.030%Autoimmune and Inflammatory Disorders Research0.022% in 202519801990200020102020

Fractional works of Autoimmune and Inflammatory Disorders Research over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Autoimmune and Inflammatory Disorders Research10.2% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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