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Fluorine in Organic Chemistry

Fluorine in Organic Chemistry is a research topic within Pharmaceutical Science. Science Explorer counts 41k research works in it since 1950. 10.0% of them reached the world's top 10% most cited for their field and year.

This cluster of papers focuses on the diverse roles of fluorine in medicinal chemistry and pharmaceuticals, including its use in bioisosteres, trifluoromethylation, enantioselective fluorination, PET imaging, and agrochemicals. The papers cover a wide range of topics such as organofluorine chemistry, C–F bond activation, and the introduction of fluorine-containing functional groups.

  • Fluorine
  • Medicinal Chemistry
  • Pharmaceuticals
  • Bioisosteres
  • Trifluoromethylation
  • Organofluorine Chemistry
  • C–F Bond Activation
  • Enantioselective Fluorination
  • PET Imaging
  • Agrochemicals
Research works
41k
fractional, since 1950
In the world top 10%
4k
per year above
Top-10% rate
10.0%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
+17%
the tick is no change
Largest producer
China
48% of the 10 largest, 2022-now
Fluorine in Organic Chemistry

Which countries lead Fluorine in Organic Chemistry research?

By volume, China and the United States publish the most (1.7k and 493 works in 2022-now).

By volume, 2022-now

  1. 1 China 1.7k works
  2. 2 United States 493 works
  3. 3 Japan 258 works
  4. 4 Russia 216 works
  5. 5 Germany 216 works
  6. 6 India 203 works
  7. 7 France 158 works
  8. 8 United Kingdom 105 works
  9. 9 Canada 72 works
  10. 10 Spain 69 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

China: 48.5%United States: 14.2%Japan: 7.4%Russia: 6.2%6 others listed: 23.7%48%largest
China1,684 · 48.5%United States493 · 14.2%Japan258 · 7.4%Russia216 · 6.2%6 others listed823 · 23.7%

Shares of the rows listed above, not of the whole node.

Which institutions lead Fluorine in Organic Chemistry research?

By volume in 2022-now, Chinese Academy of Sciences publishes the most Fluorine in Organic Chemistry research, followed by Russian Academy of Sciences and Centre National de la Recherche Scientifique.

By volume, 2022-now

  1. 1 Chinese Academy of SciencesChina 148 works
  2. 2 Russian Academy of SciencesRussia 124 works
  3. 3 Centre National de la Recherche ScientifiqueFrance 79 works
  4. 4 Nankai UniversityChina 36 works
  5. 5 University of Chinese Academy of SciencesChina 36 works
  6. 6 Henan Normal UniversityChina 33 works
  7. 7 Sichuan UniversityChina 32 works
  8. 8 National Academy of Sciences of UkraineUkraine 32 works
  9. 9 Zhejiang University of TechnologyChina 30 works
  10. 10 Nanjing Tech UniversityChina 28 works

Who are the leading researchers in Fluorine in Organic Chemistry?

The most-cited researchers publishing on Fluorine in Organic Chemistry include Michaël Grätzel, Jeremy Grimshaw and George M. Whitesides.

  1. 1 Michaël Grätzel Switzerland 458k citations
  2. 2 Jeremy Grimshaw Canada 281k citations
  3. 3 George M. Whitesides United States 267k citations
  4. 4 Wei Huang China 267k citations
  5. 5 Ben Zhong Tang China 261k citations
  6. 6 Donald G. Truhlar United States 230k citations
  7. 7 Stefan Grimme Germany 224k citations
  8. 8 Kai You Wang China 224k citations
  9. 9 George M. Sheldrick Germany 220k citations
  10. 10 John Anthony Pople United States 202k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Fluorine in Organic Chemistry?

The most cited paper in Fluorine in Organic Chemistry is "Fluorine in medicinal chemistry" (Sophie Purser, Peter R. Moore, Steve Swallow et al., 2007), with 7,580 citations. Next come "Fluorine in Pharmaceuticals: Looking Beyond Intuition" (6,622) and "Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)" (4,838).

Most cited papers
#PaperReleasedCitations
1 Fluorine in medicinal chemistry Sophie Purser, Peter R. Moore, Steve Swallow et al. · Chemical Society Reviews Review 13 Dec 2007 7,580
2 Fluorine in Pharmaceuticals: Looking Beyond Intuition Klaus Müller, Christoph Faeh, François Diederich · Science 27 Sep 2007 6,622
3 Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011) Jiang Wang, María Sánchez‐Roselló, José Luis Aceña et al. · Chemical Reviews Review 3 Dec 2013 4,838
4 Understanding organofluorine chemistry. An introduction to the C–F bond David O’Hagan · Chemical Society Reviews Review 17 Oct 2007 4,043
5 Applications of Fluorine in Medicinal Chemistry Eric P. Gillis, Kyle J. Eastman, Matthew Davenport Hill et al. · Journal of Medicinal Chemistry Open access 22 Jul 2015 3,653
All 100 most cited papers, with filters and sorting

Where is Fluorine in Organic Chemistry research done?

The largest centres of Fluorine in Organic Chemistry research in 2022-now are Shanghai (China), Beijing (China), Nanjing (China) and Hangzhou (China). Among places with at least 20 works in it, it is an unusually large share of all research in Xinxiang and Irkutsk.

Largest cities, 2022-now

  1. 1 ShanghaiChina 191 works
  2. 2 BeijingChina 179 works
  3. 3 NanjingChina 114 works
  4. 4 HangzhouChina 84 works
  5. 5 MoscowRussia 74 works
  6. 6 TianjinChina 72 works
  7. 7 GuangzhouChina 67 works
  8. 8 WuhanChina 61 works
  9. 9 TokyoJapan 60 works
  10. 10 KyivUkraine 56 works

Where it is the local speciality

  1. XinxiangCN · 34.4 works30×
  2. IrkutskRU · 23.6 works17×
← less than its size predicts1×more →

Location quotient: how much more of its research is in Fluorine in Organic Chemistry than the world average.

See Fluorine in Organic Chemistry on the map

Where is the best place to study Fluorine in Organic Chemistry?

Among universities, judged by research, Henan Normal University, Nankai University and Wuhan University score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%20%40%mean 20.62%fractional works in this field (log) →share of work in the world top 10% →Wuhan UniversityHenan Normal Univers…Nankai UniversityNanjing Forestry Uni…
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Henan Normal UniversityChina 78.123.6%47.2×33 +373.8%
2Nankai UniversityChina 76.422.1%15.3×36 +18.0%
3Wuhan UniversityChina 69.134.8%3.5×17 +30.9%
4Nanjing Forestry UniversityChina 67.116.3%17.1×27 +243.9%
5University of Chinese Academy of SciencesChina 66.718.2%6.3×36 -14.2%
6Sichuan UniversityChina 65.915.9%4.1×32 +134.1%
7Lanzhou UniversityChina 64.915.7%10.4×25 +44.3%
8Sun Yat-sen UniversityChina 64.516.9%3.3×24 +19.1%
9Nanjing Tech UniversityChina 62.812.9%16.2×28 +83.8%
10University of MünsterGermany 61.929.8%11.5×17 -29.2%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Fluorine in Organic Chemistry, country by country

Is Fluorine in Organic Chemistry research growing?

Output in 2022-2025 was 17% higher than in 2018-2021, peaking in 2015. The fastest-growing topics are Fluorine in Organic Chemistry.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Fluorine in Organic Chemistry as a percentage of every work published that year, 0.018% in 2024.

still counting0.050%0.10%0.15%Fluorine in Organic Chemistry0.018% in 202519801990200020102020

Fractional works of Fluorine in Organic Chemistry over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Fluorine in Organic Chemistry9.9% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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