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Topic · Nephrology

Gout, Hyperuricemia, Uric Acid

Gout, Hyperuricemia, Uric Acid is a research topic within Nephrology. Science Explorer counts 18k research works in it since 1950. 10.1% of them reached the world's top 10% most cited for their field and year.

This cluster of papers explores the role of uric acid in cardiovascular and renal health, focusing on its association with hyperuricemia, gout, hypertension, endothelial dysfunction, and metabolic syndrome. The papers also discuss the impact of xanthine oxidase inhibitors and the inflammatory pathways related to uric acid.

  • Uric Acid
  • Hyperuricemia
  • Gout
  • Cardiovascular Risk
  • Renal Disease
  • Hypertension
  • Xanthine Oxidase Inhibitors
  • Endothelial Dysfunction
  • Metabolic Syndrome
  • Inflammation
Research works
18k
fractional, since 1950
In the world top 10%
1.8k
per year above
Top-10% rate
10.1%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
+23%
the tick is no change
Largest producer
China
57% of the 10 largest, 2022-now
Gout, Hyperuricemia, Uric Acid

This ranks research output and citation impact. It says nothing about the quality of diagnosis, treatment or care.

Which countries lead Gout, Hyperuricemia, Uric Acid research?

By volume, China and the United States publish the most (2k and 467 works in 2022-now).

By volume, 2022-now

  1. 1 China 2k works
  2. 2 United States 467 works
  3. 3 India 212 works
  4. 4 Japan 186 works
  5. 5 South Korea 148 works
  6. 6 United Kingdom 106 works
  7. 7 Türkiye 103 works
  8. 8 Indonesia 93 works
  9. 9 Italy 88 works
  10. 10 France 82 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

China: 56.9%United States: 13.6%India: 6.2%Japan: 5.4%6 others listed: 18.0%57%largest
China1,955 · 56.9%United States467 · 13.6%India212 · 6.2%Japan186 · 5.4%6 others listed619 · 18.0%

Shares of the rows listed above, not of the whole node.

Which institutions lead Gout, Hyperuricemia, Uric Acid research?

By volume in 2022-now, Sichuan University publishes the most Gout, Hyperuricemia, Uric Acid research, followed by Qingdao University and Sun Yat-sen University.

By volume, 2022-now

  1. 1 Sichuan UniversityChina 37 works
  2. 2 Qingdao UniversityChina 34 works
  3. 3 Sun Yat-sen UniversityChina 33 works
  4. 4 Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 32 works
  5. 5 Capital Medical UniversityChina 32 works
  6. 6 Harvard UniversityUnited States 32 works
  7. 7 Shanghai Jiao Tong UniversityChina 31 works
  8. 8 Guangzhou University of Chinese MedicineChina 31 works
  9. 9 Fudan UniversityChina 29 works
  10. 10 Central South UniversityChina 29 works

Who are the leading researchers in Gout, Hyperuricemia, Uric Acid?

The most-cited researchers publishing on Gout, Hyperuricemia, Uric Acid include Theo Vos, George Davey Smith and Walter Churchill Willett.

  1. 1 Theo Vos United States 439k citations
  2. 2 George Davey Smith United Kingdom 435k citations
  3. 3 Walter Churchill Willett United States 411k citations
  4. 4 John J.V. McMurray United Kingdom 349k citations
  5. 5 Hermann Brenner Germany 343k citations
  6. 6 Cyrus Cooper United Kingdom 342k citations
  7. 7 Jun Wang China 340k citations
  8. 8 Giuseppe Remuzzi Italy 328k citations
  9. 9 Gordon Henry Guyatt Canada 315k citations
  10. 10 Gregory Y.H. Lip United Kingdom 311k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Gout, Hyperuricemia, Uric Acid?

The most cited paper in Gout, Hyperuricemia, Uric Acid is "Global, regional, and national burden of chronic kidney disease, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017" (Boris T. Bikbov et al., 2020), with 6,840 citations. Next come "Gout-associated uric acid crystals activate the NALP3 inflammasome" (5,341) and "2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative" (5,002).

Most cited papers
#PaperReleasedCitations
1 Global, regional, and national burden of chronic kidney disease, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017 Boris T. Bikbov et al. · The Lancet Open access223 authors Feb 2020 6,840
2 Gout-associated uric acid crystals activate the NALP3 inflammasome Fabio Martinon, Virginie Pétrilli, Annick Mayor et al. · Nature 11 Jan 2006 5,341
3 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative Daniel Aletaha et al. · Annals of the Rheumatic Diseases Open access 10 Aug 2010 5,002
4 Pyroptosis: host cell death and inflammation Tessa Bergsbaken, Susan L. Fink, Brad T. Cookson · Nature Reviews Microbiology ReviewOpen access 16 Jan 2009 3,313
5 Cryopyrin activates the inflammasome in response to toxins and ATP Sanjeev Mariathasan, David S. Weiss, Kim I. Newton et al. · Nature 11 Jan 2006 3,104
All 99 most cited papers, with filters and sorting

Where is Gout, Hyperuricemia, Uric Acid research done?

The largest centres of Gout, Hyperuricemia, Uric Acid research in 2022-now are Beijing (China), Guangzhou (China), Shanghai (China) and Hangzhou (China).

Largest cities, 2022-now

  1. 1 BeijingChina 228 works
  2. 2 GuangzhouChina 156 works
  3. 3 ShanghaiChina 128 works
  4. 4 HangzhouChina 87 works
  5. 5 ChengduChina 79 works
  6. 6 NanjingChina 67 works
  7. 7 SeoulSouth Korea 65 works
  8. 8 TokyoJapan 52 works
  9. 9 QingdaoChina 52 works
  10. 10 ChangshaChina 52 works
See Gout, Hyperuricemia, Uric Acid on the map

Where is the best place to study Gout, Hyperuricemia, Uric Acid?

Among universities, judged by research, Harvard University, Anhui Medical University and Guangzhou University of Chinese Medicine score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%20%40%mean 18.04%fractional works in this field (log) →share of work in the world top 10% →Anhui Medical Univer…Harvard UniversitySichuan UniversityGuangzhou University…
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Harvard UniversityUnited States 74.516.3%2.5×32 -9.6%
2Anhui Medical UniversityChina 72.522.1%12.2×22 +77.5%
3Guangzhou University of Chinese MedicineChina 71.514.5%32.2×31 +297.1%
4Sichuan UniversityChina 70.915.0%4.1×37 +50.1%
5Wenzhou Medical UniversityChina 70.219.5%10.1×20 +133.3%
6China Medical UniversityChina 68.330.6%8.8×15 +11.0%
7Zhejiang UniversityChina 68.116.6%2.7×29 +66.0%
8Nanchang UniversityChina 67.817.0%7.2×22 +90.0%
9Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 67.613.5%7.7×32 +90.3%
10Beijing University of Chinese MedicineChina 66.015.3%30.8×29 +238.0%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Gout, Hyperuricemia, Uric Acid, country by country

Is Gout, Hyperuricemia, Uric Acid research growing?

Output in 2022-2025 was 23% higher than in 2018-2021, peaking in 2025. The fastest-growing topics are Gout, Hyperuricemia, Uric Acid.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Gout, Hyperuricemia, Uric Acid as a percentage of every work published that year, 0.019% in 2024.

still counting0.010%0.020%0.030%Gout, Hyperuricemia, Uric Acid0.021% in 202519801990200020102020

Fractional works of Gout, Hyperuricemia, Uric Acid over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Gout, Hyperuricemia, Uric Acid10.1% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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