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Topic · Physiology

Histiocytic Disorders and Treatments

Histiocytic Disorders and Treatments is a research topic within Physiology. Science Explorer counts 12k research works in it since 1950. 10.3% of them reached the world's top 10% most cited for their field and year.

This cluster of papers focuses on the classification, diagnosis, and treatment of histiocytic disorders, including Langerhans Cell Histiocytosis and Erdheim-Chester Disease. It explores the role of BRAF mutations, immunohistochemical approaches to classification, and consensus guidelines for clinical management. The papers also delve into the pathogenesis, molecular characterization, and therapy intensification for multisystem involvement.

  • Langerhans Cell Histiocytosis
  • Erdheim-Chester Disease
  • Dendritic Cell Neoplasms
  • BRAF Mutations
  • Clinical Management
  • Immunohistochemical Approach
  • Multisystem Involvement
  • Therapy Intensification
  • Pathogenesis
  • Molecular Characterization
Research works
12k
fractional, since 1950
In the world top 10%
1.2k
per year above
Top-10% rate
10.3%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
+8%
the tick is no change
Largest producer
United States
32% of the 10 largest, 2022-now
Histiocytic Disorders and Treatments

This ranks research output and citation impact. It says nothing about the quality of diagnosis, treatment or care.

Which countries lead Histiocytic Disorders and Treatments research?

By volume, the United States and China publish the most (508 and 332 works in 2022-now).

By volume, 2022-now

  1. 1 United States 508 works
  2. 2 China 332 works
  3. 3 India 208 works
  4. 4 Japan 116 works
  5. 5 France 89 works
  6. 6 Brazil 74 works
  7. 7 Spain 71 works
  8. 8 Italy 68 works
  9. 9 Türkiye 54 works
  10. 10 Germany 53 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

United States: 32.3%China: 21.1%India: 13.2%Japan: 7.4%6 others listed: 26.0%32%largest
United States508 · 32.3%China332 · 21.1%India208 · 13.2%Japan116 · 7.4%6 others listed409 · 26.0%

Shares of the rows listed above, not of the whole node.

Which institutions lead Histiocytic Disorders and Treatments research?

By volume in 2022-now, Mayo Clinic publishes the most Histiocytic Disorders and Treatments research, followed by All India Institute of Medical Sciences and Sichuan University.

Who are the leading researchers in Histiocytic Disorders and Treatments?

The most-cited researchers publishing on Histiocytic Disorders and Treatments include Jun Wang, Gregory Y.H. Lip and Hagop M. Kantarjian.

  1. 1 Jun Wang China 340k citations
  2. 2 Gregory Y.H. Lip United Kingdom 311k citations
  3. 3 Hagop M. Kantarjian United States 273k citations
  4. 4 Kaj Blennow Sweden 247k citations
  5. 5 Richard Anthony Flavell United States 237k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Histiocytic Disorders and Treatments?

The most cited paper in Histiocytic Disorders and Treatments is "The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms" (Joseph David Khoury et al., 2022), with 4,204 citations. Next come "Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin" (3,284) and "Establishment and characterization of a human histiocytic lymphoma cell line (U‐937)" (2,436).

Most cited papers
#PaperReleasedCitations
1 The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms Joseph David Khoury et al. · Leukemia Open access 22 Jun 2022 4,204
2 Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin Yupeng Wang, Wenqing Gao, Xuyan Shi et al. · Nature 28 Apr 2017 3,284
3 Establishment and characterization of a human histiocytic lymphoma cell line (U‐937) Christer Sundström, Kenneth Nilsson · International Journal of Cancer 15 May 1976 2,436
4 Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's disease [see comments] Jean Pierre Soulier, Laurence Grollet, Éric Oksenhendler et al. · Blood 15 Aug 1995 2,200
5 The Tuberous Sclerosis Complex Peter B. Crino, Katherine L. Nathanson, Elizabeth P. Henske · New England Journal of Medicine 27 Sep 2006 1,793
All 100 most cited papers, with filters and sorting

Where is Histiocytic Disorders and Treatments research done?

The largest centres of Histiocytic Disorders and Treatments research in 2022-now are Beijing (China), Paris (France), New Delhi (India) and Chengdu (China).

Largest cities, 2022-now

  1. 1 BeijingChina 73 works
  2. 2 ParisFrance 40 works
  3. 3 New DelhiIndia 34 works
  4. 4 ChengduChina 27 works
  5. 5 TokyoJapan 27 works
  6. 6 New YorkUnited States 23 works
  7. 7 ShanghaiChina 23 works
  8. 8 São PauloBrazil 22 works
  9. 9 IstanbulTürkiye 21 works
  10. 10 HoustonUnited States 20 works
See Histiocytic Disorders and Treatments on the map

Where is the best place to study Histiocytic Disorders and Treatments?

Among universities, judged by research, Harvard University, Sorbonne Université and Capital Medical University score highest, combining citation excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%10%20%mean 14.86%fractional works in this field (log) →share of work in the world top 10% →Harvard UniversitySorbonne UniversitéCapital Medical Univ…Sichuan University
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Citation excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Harvard UniversityUnited States 75.522.9%3.4×20 -11.1%
2Sorbonne UniversitéFrance 62.815.5%9.6×12 -0.6%
3Capital Medical UniversityChina 59.114.3%9.8×20 +75.6%
4Sichuan UniversityChina 55.511.6%4.9×21 +41.6%
5Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 55.412.1%8.4×17 +39.2%
6Université Paris CitéFrance 54.822.8%7.6×11 -15.3%
7University of Alabama at BirminghamUnited States 53.821.9%10.2×9 +192.7%
8All India Institute of Medical SciencesIndia 50.00.9%13.2×27 +25.9%
9Tsinghua UniversityChina 48.712.3%3.5×15 +55.4%
10Baylor College of MedicineUnited States 45.714.3%10.8×10 -2.2%

Universities only. The score blends citation excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Histiocytic Disorders and Treatments, country by country

Is Histiocytic Disorders and Treatments research growing?

Output in 2022-2025 was 8% higher than in 2018-2021, peaking in 2025. The fastest-growing topics are Histiocytic Disorders and Treatments.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Histiocytic Disorders and Treatments as a percentage of every work published that year, 0.0087% in 2024.

still counting0.010%0.020%Histiocytic Disorders and Treatments0.0090% in 202519801990200020102020

Fractional works of Histiocytic Disorders and Treatments over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Histiocytic Disorders and Treatments10.3% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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