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Topic · Biotechnology

Cancer Research and Treatments

Cancer Research and Treatments is a research topic within Biotechnology. Science Explorer counts 48k research works in it since 1950. 10.5% of them reached the world's top 10% most cited for their field and year.

This cluster of papers focuses on the use of engineered bacteria, particularly Salmonella typhimurium, for targeted cancer therapy. The research involves various strategies such as tumor-specific colonization, gene delivery, immunotherapy, and metabolic manipulation to induce tumor regression and enhance anti-tumor immunity. Fluorescent protein imaging is utilized to visualize tumor growth, metastasis, and angiogenesis in live animals. Additionally, the cluster explores the use of bacterial vectors for gene therapy and the potential of arginine deprivation as a targeted therapy for certain cancers.

  • Bacterial Therapy
  • Tumor Targeting
  • Arginine Deprivation
  • Fluorescent Protein Imaging
  • Metastatic Cancer
  • Gene Therapy
  • Immunotherapy
  • Salmonella Typhimurium
  • Tumor Regression
  • Cancer Metabolism
Research works
48k
fractional, since 1950
In the world top 10%
5.1k
per year above
Top-10% rate
10.5%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
+18%
the tick is no change
Largest producer
China
38% of the 10 largest, 2022-now
Cancer Research and Treatments

Which countries lead Cancer Research and Treatments research?

By volume, China and the United States publish the most (2.8k and 2.4k works in 2022-now).

By volume, 2022-now

  1. 1 China 2.8k works
  2. 2 United States 2.4k works
  3. 3 India 418 works
  4. 4 Japan 404 works
  5. 5 Germany 283 works
  6. 6 South Korea 269 works
  7. 7 United Kingdom 244 works
  8. 8 Italy 189 works
  9. 9 France 189 works
  10. 10 Iran 173 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

China: 38.4%United States: 32.0%India: 5.7%Japan: 5.5%6 others listed: 18.3%38%largest
China2,824 · 38.4%United States2,355 · 32.0%India418 · 5.7%Japan404 · 5.5%6 others listed1,348 · 18.3%

Shares of the rows listed above, not of the whole node.

Which institutions lead Cancer Research and Treatments research?

By volume in 2022-now, Harvard University publishes the most Cancer Research and Treatments research, followed by The University of Texas MD Anderson Cancer Center and Sun Yat-sen University.

By volume, 2022-now

  1. 1 Harvard UniversityUnited States 85 works
  2. 2 The University of Texas MD Anderson Cancer CenterUnited States 83 works
  3. 3 Sun Yat-sen UniversityChina 82 works
  4. 4 Chinese Academy of SciencesChina 74 works
  5. 5 Shanghai Jiao Tong UniversityChina 73 works
  6. 6 Sichuan UniversityChina 63 works
  7. 7 Zhejiang UniversityChina 62 works
  8. 8 Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 55 works
  9. 9 National Institutes of HealthUnited States 54 works
  10. 10 Russian Academy of SciencesRussia 52 works

Who are the leading researchers in Cancer Research and Treatments?

The most-cited researchers publishing on Cancer Research and Treatments include Eric S. Lander, Rob Knight and George Davey Smith.

  1. 1 Eric S. Lander United States 524k citations
  2. 2 Rob Knight United States 468k citations
  3. 3 George Davey Smith United Kingdom 435k citations
  4. 4 Peer Bork Germany 396k citations
  5. 5 Robert John Tibshirani United States 396k citations
  6. 6 Guido Kroemer France 386k citations
  7. 7 Bert Vogelstein United States 373k citations
  8. 8 Gad A. Getz United States 364k citations
  9. 9 Elaine R. Mardis United States 346k citations
  10. 10 Hermann Brenner Germany 343k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Cancer Research and Treatments?

The most cited paper in Cancer Research and Treatments is "Radiotherapy Plus Concomitant and Adjuvant Temozolomide for Glioblastoma" (Roger Stupp, Warren P. Mason, Martin J. van den Bent et al., 2005), with 22,109 citations. Next come "Hallmarks of Cancer: New Dimensions" (9,794) and "Microenvironmental regulation of tumor progression and metastasis" (8,290).

Most cited papers
#PaperReleasedCitations
1 Radiotherapy Plus Concomitant and Adjuvant Temozolomide for Glioblastoma Roger Stupp, Warren P. Mason, Martin J. van den Bent et al. · New England Journal of Medicine Open access 9 Mar 2005 22,109
2 Hallmarks of Cancer: New Dimensions Douglas Hanahan · Cancer Discovery Open access 2022 9,794
3 Microenvironmental regulation of tumor progression and metastasis Daniela F. Quail, Johanna A. Joyce · Nature Medicine Open access Nov 2013 8,290
4 Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial Roger Stupp et al. · The Lancet Oncology 10 Mar 2009 7,889
5 Specific Association of Human Telomerase Activity with Immortal Cells and Cancer Nam W. Kim, Mieczyslaw A. Piatyszek, Karen R. Prowse et al. · Science 23 Dec 1994 7,190
All 100 most cited papers, with filters and sorting

Where is Cancer Research and Treatments research done?

The largest centres of Cancer Research and Treatments research in 2022-now are Beijing (China), Shanghai (China), Guangzhou (China) and Nanjing (China).

Largest cities, 2022-now

  1. 1 BeijingChina 321 works
  2. 2 ShanghaiChina 273 works
  3. 3 GuangzhouChina 182 works
  4. 4 NanjingChina 148 works
  5. 5 HangzhouChina 138 works
  6. 6 HoustonUnited States 129 works
  7. 7 SeoulSouth Korea 123 works
  8. 8 New YorkUnited States 120 works
  9. 9 WuhanChina 117 works
  10. 10 ChengduChina 101 works
See Cancer Research and Treatments on the map

Where is the best place to study Cancer Research and Treatments?

Among universities, judged by research, Columbia University, Harvard University and Wuhan University score highest, combining citation excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%20%40%mean 20.4%fractional works in this field (log) →share of work in the world top 10% →Columbia UniversityWuhan UniversitySun Yat-sen UniversityHarvard University
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Citation excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Columbia UniversityUnited States 71.930.0%2.6×23 +65.9%
2Harvard UniversityUnited States 71.412.5%3.3×85 -7.4%
3Wuhan UniversityChina 68.328.3%3.2×36 +19.9%
4Sun Yat-sen UniversityChina 67.315.7%4.9×82 +64.0%
5Zhejiang UniversityChina 66.218.2%2.9×62 +23.0%
6Soochow UniversityChina 65.822.7%5.7×44 +72.2%
7Tongji UniversityChina 65.527.9%2.2×27 +123.5%
8Shanghai Jiao Tong UniversityChina 65.017.2%3.1×73 +72.2%
9Sichuan UniversityChina 64.518.0%3.5×63 +30.5%
10Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 60.213.5%6.5×55 +46.0%

Universities only. The score blends citation excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Cancer Research and Treatments, country by country

Is Cancer Research and Treatments research growing?

Output in 2022-2025 was 18% higher than in 2018-2021, peaking in 2025. The fastest-growing topics are Cancer Research and Treatments.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Cancer Research and Treatments as a percentage of every work published that year, 0.034% in 2024.

still counting0.025%0.050%0.075%Cancer Research and Treatments0.040% in 202519801990200020102020

Fractional works of Cancer Research and Treatments over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Cancer Research and Treatments10.3% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

Questions people ask

Who is researching a cure for cancer?

By volume in 2022-now, Harvard University publishes the most Cancer Research and Treatments research, followed by The University of Texas MD Anderson Cancer Center and Sun Yat-sen University. By volume, China and the United States publish the most (2.8k and 2.4k works in 2022-now).

How much research is there on cancer, and is it growing?

Output in 2022-2025 was 18% higher than in 2018-2021, peaking in 2025. The fastest-growing topics are Cancer Research and Treatments.

Is Cancer Research and Treatments research growing?
All 1,273 questions in the Question Catalogue

Discussion

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