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Topic · Cardiology and Cardiovascular Medicine

Cardiac Fibrosis and Remodeling

Cardiac Fibrosis and Remodeling is a research topic within Cardiology and Cardiovascular Medicine. Science Explorer counts 19k research works in it since 1951. 9.9% of them reached the world's top 10% most cited for their field and year.

This cluster of papers explores the molecular mechanisms underlying cardiac remodeling and repair, focusing on the inflammatory response, myocardial infarction, fibrosis, hypertrophy, macrophage involvement, extracellular matrix dynamics, and the role of cytokines in heart failure.

  • Cardiac Remodeling
  • Inflammatory Response
  • Myocardial Infarction
  • Fibrosis
  • Hypertrophy
  • Macrophages
  • Extracellular Matrix
  • Tumor Necrosis Factor
  • Cytokines
  • Heart Failure
Research works
19k
fractional, since 1951
In the world top 10%
1.9k
per year above
Top-10% rate
9.9%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
+26%
the tick is no change
Largest producer
China
49% of the 10 largest, 2022-now
Cardiac Fibrosis and Remodeling

This ranks research output and citation impact. It says nothing about the quality of diagnosis, treatment or care.

Which countries lead Cardiac Fibrosis and Remodeling research?

By volume, China and the United States publish the most (1.9k and 957 works in 2022-now).

By volume, 2022-now

  1. 1 China 1.9k works
  2. 2 United States 957 works
  3. 3 Germany 228 works
  4. 4 Japan 148 works
  5. 5 United Kingdom 133 works
  6. 6 Italy 112 works
  7. 7 India 91 works
  8. 8 Canada 88 works
  9. 9 Spain 86 works
  10. 10 France 80 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

China: 49.1%United States: 25.3%Germany: 6.0%Japan: 3.9%6 others listed: 15.6%49%largest
China1,855 · 49.1%United States957 · 25.3%Germany228 · 6.0%Japan148 · 3.9%6 others listed590 · 15.6%

Shares of the rows listed above, not of the whole node.

Which institutions lead Cardiac Fibrosis and Remodeling research?

By volume in 2022-now, Chinese Academy of Medical Sciences & Peking Union Medical College publishes the most Cardiac Fibrosis and Remodeling research, followed by Shanghai Jiao Tong University and Nanjing Medical University.

By volume, 2022-now

  1. 1 Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 61 works
  2. 2 Shanghai Jiao Tong UniversityChina 51 works
  3. 3 Nanjing Medical UniversityChina 46 works
  4. 4 Wuhan UniversityChina 44 works
  5. 5 Harvard UniversityUnited States 43 works
  6. 6 Capital Medical UniversityChina 39 works
  7. 7 Harbin Medical UniversityChina 32 works
  8. 8 Zhejiang UniversityChina 32 works
  9. 9 Huazhong University of Science and TechnologyChina 32 works
  10. 10 Sun Yat-sen UniversityChina 30 works

Who are the leading researchers in Cardiac Fibrosis and Remodeling?

The most-cited researchers publishing on Cardiac Fibrosis and Remodeling include John J.V. McMurray, Hermann Brenner and Shizuo Akira.

  1. 1 John J.V. McMurray United Kingdom 349k citations
  2. 2 Hermann Brenner Germany 343k citations
  3. 3 Shizuo Akira Japan 342k citations
  4. 4 Emelia J. Benjamin United States 341k citations
  5. 5 Jun Wang China 340k citations
  6. 6 Stephan Windecker Switzerland 338k citations
  7. 7 Gregory Y.H. Lip United Kingdom 311k citations
  8. 8 Matthias Mann Germany 308k citations
  9. 9 Peter Jüni Switzerland 303k citations
  10. 10 Salim Yusuf Canada 294k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Cardiac Fibrosis and Remodeling?

The most cited paper in Cardiac Fibrosis and Remodeling is "Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein" (Paul M. Ridker, Eleanor Danielson, Francisco Antônio Helfenstein Fonseca et al., 2008), with 6,727 citations. Next come "Effect of Captopril on Mortality and Morbidity in Patients with Left Ventricular Dysfunction after Myocardial Infarction" (5,965) and "Bone marrow cells regenerate infarcted myocardium" (5,184).

Most cited papers
#PaperReleasedCitations
1 Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein Paul M. Ridker, Eleanor Danielson, Francisco Antônio Helfenstein Fonseca et al. · New England Journal of Medicine Open access 9 Nov 2008 6,727
2 Effect of Captopril on Mortality and Morbidity in Patients with Left Ventricular Dysfunction after Myocardial Infarction Marc Alan Pfeffer, Eugene Braunwald, Lemuel A. Moyé et al. · New England Journal of Medicine 3 Sep 1992 5,965
3 Bone marrow cells regenerate infarcted myocardium Donald Orlic, Jan Kajstura, Stefano Chimenti et al. · Nature 5 Apr 2001 5,184
4 Efficacy and Safety of Low-Dose Colchicine after Myocardial Infarction Jean‐Claude Tardif et al. · New England Journal of Medicine Open access 16 Nov 2019 3,135
5 Neurohumoral Features of Myocardial Stunning Due to Sudden Emotional Stress Ilan Shor Wittstein, David R. Thiemann, João A.C. Lima et al. · New England Journal of Medicine Open access 9 Feb 2005 3,132
All 99 most cited papers, with filters and sorting

Where is Cardiac Fibrosis and Remodeling research done?

The largest centres of Cardiac Fibrosis and Remodeling research in 2022-now are Beijing (China), Shanghai (China), Guangzhou (China) and Nanjing (China). Among places with at least 20 works in it, it is an unusually large share of all research in Shijiazhuang.

Largest cities, 2022-now

  1. 1 BeijingChina 220 works
  2. 2 ShanghaiChina 170 works
  3. 3 GuangzhouChina 119 works
  4. 4 NanjingChina 93 works
  5. 5 WuhanChina 93 works
  6. 6 HangzhouChina 65 works
  7. 7 ChangshaChina 51 works
  8. 8 JinanChina 49 works
  9. 9 TianjinChina 48 works
  10. 10 LondonUnited Kingdom 47 works

Where it is the local speciality

  1. ShijiazhuangCN · 29.4 works6.1×
← less than its size predicts1×more →

Location quotient: how much more of its research is in Cardiac Fibrosis and Remodeling than the world average.

See Cardiac Fibrosis and Remodeling on the map

Where is the best place to study Cardiac Fibrosis and Remodeling?

Among universities, judged by research, Harvard University, Albert Einstein College of Medicine and Chinese Academy of Medical Sciences & Peking Union Medical College score highest, combining citation excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%20%40%mean 16.29%fractional works in this field (log) →share of work in the world top 10% →Albert Einstein Coll…Harvard UniversityChinese Academy of M…Shanghai Jiao Tong U…
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Citation excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Harvard UniversityUnited States 69.717.3%3.3×43 +42.9%
2Albert Einstein College of MedicineUnited States 69.330.9%11.2×15 +5.2%
3Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 64.514.4%14.2×60 +98.0%
4Shanghai Jiao Tong UniversityChina 59.012.9%4.4×51 +40.1%
5Washington University in St. LouisUnited States 58.121.0%7.6×22 +150.3%
6Nanjing Medical UniversityChina 55.19.4%12.9×46 +49.7%
7Zhejiang UniversityChina 54.619.5%2.9×32 +103.2%
8Heidelberg UniversityGermany 54.513.1%6.6×20 +80.2%
9Huazhong University of Science and TechnologyChina 53.416.8%4.3×32 +71.3%
10Capital Medical UniversityChina 51.57.6%9.1×39 +33.7%

Universities only. The score blends citation excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Cardiac Fibrosis and Remodeling, country by country

Is Cardiac Fibrosis and Remodeling research growing?

Output in 2022-2025 was 26% higher than in 2018-2021, peaking in 2025. The fastest-growing topics are Cardiac Fibrosis and Remodeling.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Cardiac Fibrosis and Remodeling as a percentage of every work published that year, 0.016% in 2024.

still counting0.010%0.020%0.030%Cardiac Fibrosis and Remodeling0.021% in 202519801990200020102020

Fractional works of Cardiac Fibrosis and Remodeling over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Cardiac Fibrosis and Remodeling9.8% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

Discussion

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