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Topic · Clinical Biochemistry

Paraoxonase enzyme and polymorphisms

Paraoxonase enzyme and polymorphisms is a research topic within Clinical Biochemistry. Science Explorer counts 5.1k research works in it since 1955. 10.1% of them reached the world's top 10% most cited for their field and year.

This cluster of papers focuses on the role of paraoxonase enzymes in atherosclerosis, oxidative stress, and cardiovascular diseases. It explores the genetic polymorphisms, enzyme activity, and the impact of paraoxonase on lipid peroxidation and inflammation. The research also delves into the association between paraoxonase and high-density lipoproteins (HDL) as well as its potential as an antioxidant.

  • Paraoxonase
  • Atherosclerosis
  • Oxidative Stress
  • Antioxidant
  • Cardiovascular Disease
  • Genetic Polymorphisms
  • HDL
  • Enzyme Activity
  • Lipid Peroxidation
  • Inflammation
Research works
5.1k
fractional, since 1955
In the world top 10%
516
per year above
Top-10% rate
10.1%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
-9%
the tick is no change
Largest producer
China
26% of the 10 largest, 2022-now
Paraoxonase enzyme and polymorphisms

Which countries lead Paraoxonase enzyme and polymorphisms research?

By volume, China and Türkiye publish the most (133 and 79 works in 2022-now).

By volume, 2022-now

  1. 1 China 133 works
  2. 2 Türkiye 79 works
  3. 3 United States 70 works
  4. 4 India 56 works
  5. 5 Iran 55 works
  6. 6 Iraq 31 works
  7. 7 Egypt 29 works
  8. 8 Italy 23 works
  9. 9 Poland 22 works
  10. 10 Japan 20 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

China: 25.6%Türkiye: 15.2%United States: 13.5%India: 10.9%6 others listed: 34.8%26%largest
China133 · 25.6%Türkiye79 · 15.2%United States70 · 13.5%India56 · 10.9%6 others listed180 · 34.8%

Shares of the rows listed above, not of the whole node.

Which institutions lead Paraoxonase enzyme and polymorphisms research?

By volume in 2022-now, University of Baghdad publishes the most Paraoxonase enzyme and polymorphisms research, followed by Capital Medical University and Tehran University of Medical Sciences.

By volume, 2022-now

  1. 1 University of BaghdadIraq 5 works
  2. 2 Capital Medical UniversityChina 5 works
  3. 3 Tehran University of Medical SciencesIran 5 works
  4. 4 Islamic Azad University, TehranIran 5 works
  5. 5 University of BelgradeSerbia 4 works
  6. 6 Nanjing Medical UniversityChina 4 works
  7. 7 Isfahan University of Medical SciencesIran 4 works
  8. 8 National Research CentreEgypt 4 works
  9. 9 Tabriz University of Medical SciencesIran 4 works
  10. 10 Harvard UniversityUnited States 3 works

Who are the leading researchers in Paraoxonase enzyme and polymorphisms?

The most-cited researchers publishing on Paraoxonase enzyme and polymorphisms include George Davey Smith, Walter Churchill Willett and Hermann Brenner.

  1. 1 George Davey Smith United Kingdom 435k citations
  2. 2 Walter Churchill Willett United States 411k citations
  3. 3 Hermann Brenner Germany 343k citations
  4. 4 Gregory Y.H. Lip United Kingdom 311k citations
  5. 5 Salim Yusuf Canada 294k citations
  6. 6 Luigi Ferrucci United States 281k citations
  7. 7 Frank B. Hu United States 281k citations
  8. 8 JoAnn E. Manson United States 263k citations
  9. 9 Amirhossein Sahebkar Iran 258k citations
  10. 10 Tommi Juhani Vasankari Finland 248k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Paraoxonase enzyme and polymorphisms?

The most cited paper in Paraoxonase enzyme and polymorphisms is "C-Reactive Protein and Other Markers of Inflammation in the Prediction of Cardiovascular Disease in Women" (Paul M. Ridker, Charles H. Hennekens, Julie E. Buring et al., 2000), with 5,889 citations. Next come "Vitamin E Consumption and the Risk of Coronary Heart Disease in Men" (2,365) and "Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS)" (2,158).

Most cited papers
#PaperReleasedCitations
1 C-Reactive Protein and Other Markers of Inflammation in the Prediction of Cardiovascular Disease in Women Paul M. Ridker, Charles H. Hennekens, Julie E. Buring et al. · New England Journal of Medicine Open access 23 Mar 2000 5,889
2 Vitamin E Consumption and the Risk of Coronary Heart Disease in Men Eric B. Rimm, Meir J. Stampfer, Alberto Ascherio et al. · New England Journal of Medicine Open access 20 May 1993 2,365
3 Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS) Nigel G. Stephens, A Parsons, Matthew A. Brown et al. · The Lancet Mar 1996 2,158
4 Vitamin E Consumption and the Risk of Coronary Disease in Women Meir J. Stampfer, Charles H. Hennekens, JoAnn E. Manson et al. · New England Journal of Medicine Open access 20 May 1993 2,119
5 Homocysteine and Risk of Ischemic Heart Disease and Stroke Homocysteine Studies Collaboration · JAMA Open access 23 Oct 2002 2,077
All 100 most cited papers, with filters and sorting

Where is Paraoxonase enzyme and polymorphisms research done?

The largest centres of Paraoxonase enzyme and polymorphisms research in 2022-now are Beijing (China), Tehran (Iran), Baghdad (Iraq) and Istanbul (Türkiye).

Largest cities, 2022-now

  1. 1 BeijingChina 17 works
  2. 2 TehranIran 15 works
  3. 3 BaghdadIraq 12 works
  4. 4 IstanbulTürkiye 12 works
  5. 5 AnkaraTürkiye 11 works
  6. 6 CairoEgypt 8 works
  7. 7 GuangzhouChina 7 works
  8. 8 New DelhiIndia 7 works
  9. 9 ChennaiIndia 6 works
  10. 10 São PauloBrazil 6 works
See Paraoxonase enzyme and polymorphisms on the map

Is Paraoxonase enzyme and polymorphisms research growing?

Output in 2022-2025 was 9% lower than in 2018-2021, peaking in 2014.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Paraoxonase enzyme and polymorphisms as a percentage of every work published that year, 0.0028% in 2024.

still counting0.0050%0.010%Paraoxonase enzyme and polymorphisms0.0030% in 202519801990200020102020

Fractional works of Paraoxonase enzyme and polymorphisms over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Paraoxonase enzyme and polymorphisms10.3% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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