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Topic · Clinical Biochemistry

Advanced Glycation End Products research

Advanced Glycation End Products research is a research topic within Clinical Biochemistry. Science Explorer counts 23k research works in it since 1950. 10.0% of them reached the world's top 10% most cited for their field and year.

This cluster of papers focuses on the biochemistry and molecular cell biology of diabetic complications, particularly exploring the role of Advanced Glycation End Products (AGEs), HMGB1, oxidative stress, inflammation, and the receptor for AGEs (RAGE) in the pathobiology of diabetes. The papers also delve into the involvement of mitochondrial superoxide, toll-like receptors, necrotic cells, and cellular signaling pathways in diabetic complications.

  • Advanced Glycation End Products
  • HMGB1
  • Oxidative Stress
  • Inflammation
  • RAGE
  • Diabetes
  • Mitochondrial Superoxide
  • Toll-like Receptors
  • Necrotic Cells
  • Cellular Signaling
Research works
23k
fractional, since 1950
In the world top 10%
2.3k
per year above
Top-10% rate
10.0%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
+0%
the tick is no change
Largest producer
China
48% of the 10 largest, 2022-now
Advanced Glycation End Products research

Which countries lead Advanced Glycation End Products research research?

By volume, China and the United States publish the most (1.4k and 445 works in 2022-now).

By volume, 2022-now

  1. 1 China 1.4k works
  2. 2 United States 445 works
  3. 3 India 297 works
  4. 4 Japan 199 works
  5. 5 Germany 121 works
  6. 6 South Korea 115 works
  7. 7 Türkiye 111 works
  8. 8 Italy 101 works
  9. 9 Iran 80 works
  10. 10 Poland 74 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

China: 48.4%United States: 14.9%India: 9.9%Japan: 6.7%6 others listed: 20.1%48%largest
China1,448 · 48.4%United States445 · 14.9%India297 · 9.9%Japan199 · 6.7%6 others listed601 · 20.1%

Shares of the rows listed above, not of the whole node.

Which institutions lead Advanced Glycation End Products research research?

By volume in 2022-now, Nanchang University publishes the most Advanced Glycation End Products research research, followed by Shanghai Jiao Tong University and Nanjing Medical University.

By volume, 2022-now

  1. 1 Nanchang UniversityChina 37 works
  2. 2 Shanghai Jiao Tong UniversityChina 28 works
  3. 3 Nanjing Medical UniversityChina 24 works
  4. 4 Sun Yat-sen UniversityChina 22 works
  5. 5 Russian Academy of SciencesRussia 21 works
  6. 6 Harvard UniversityUnited States 21 works
  7. 7 Central South UniversityChina 20 works
  8. 8 Huazhong University of Science and TechnologyChina 19 works
  9. 9 Capital Medical UniversityChina 19 works
  10. 10 Jiangnan UniversityChina 18 works

Who are the leading researchers in Advanced Glycation End Products research?

The most-cited researchers publishing on Advanced Glycation End Products research include Walter Churchill Willett, Guido Kroemer and John J.V. McMurray.

  1. 1 Walter Churchill Willett United States 411k citations
  2. 2 Guido Kroemer France 386k citations
  3. 3 John J.V. McMurray United Kingdom 349k citations
  4. 4 Hermann Brenner Germany 343k citations
  5. 5 Shizuo Akira Japan 342k citations
  6. 6 Jun Wang China 340k citations
  7. 7 Giuseppe Remuzzi Italy 328k citations
  8. 8 John Q. Trojanowski United States 286k citations
  9. 9 Luigi Ferrucci United States 281k citations
  10. 10 Frank B. Hu United States 281k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Advanced Glycation End Products research?

The most cited paper in Advanced Glycation End Products research is "Biochemistry and molecular cell biology of diabetic complications" (Michael Brownlee, 2001), with 9,153 citations. Next come "Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study" (9,131) and "Neuroinflammation in Alzheimer's disease" (6,318).

Most cited papers
#PaperReleasedCitations
1 Biochemistry and molecular cell biology of diabetic complications Michael Brownlee · Nature 13 Dec 2001 9,153
2 Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study IRENE M. STRATTON · BMJ Open access 12 Aug 2000 9,131
3 Neuroinflammation in Alzheimer's disease Michael Thomas Heneka et al. · The Lancet Neurology Open access 16 Mar 2015 6,318
4 Oxidative Stress and Diabetic Complications Ferdinando Giacco, Michael Brownlee · Circulation Research Open access 28 Oct 2010 5,514
5 Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage Takeshi Nishikawa, Diane Edelstein, Xue Liang Du et al. · Nature Apr 2000 4,302
All 98 most cited papers, with filters and sorting

Where is Advanced Glycation End Products research research done?

The largest centres of Advanced Glycation End Products research research in 2022-now are Beijing (China), Shanghai (China), Guangzhou (China) and Nanjing (China). Among places with at least 20 works in it, it is an unusually large share of all research in Wuxi.

Largest cities, 2022-now

  1. 1 BeijingChina 149 works
  2. 2 ShanghaiChina 91 works
  3. 3 GuangzhouChina 88 works
  4. 4 NanjingChina 58 works
  5. 5 WuhanChina 57 works
  6. 6 HangzhouChina 49 works
  7. 7 TokyoJapan 49 works
  8. 8 ChangshaChina 41 works
  9. 9 SeoulSouth Korea 41 works
  10. 10 TianjinChina 41 works

Where it is the local speciality

  1. WuxiCN · 39.3 works10×
← less than its size predicts1×more →

Location quotient: how much more of its research is in Advanced Glycation End Products research than the world average.

See Advanced Glycation End Products research on the map

Where is the best place to study Advanced Glycation End Products research?

Among universities, judged by research, Nanchang University, Northeast Agricultural University and Huazhong University of Science and Technology score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%20%40%mean 19.12%fractional works in this field (log) →share of work in the world top 10% →Huazhong University …Northeast Agricultur…Nanchang UniversityHarvard University
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Nanchang UniversityChina 65.111.7%13.8×37 +13.3%
2Northeast Agricultural UniversityChina 60.023.2%13.4×12 +74.3%
3Huazhong University of Science and TechnologyChina 58.025.2%3.0×19 +4.0%
4Harvard UniversityUnited States 56.69.8%1.8×21 +13.0%
5Jiangnan UniversityChina 55.213.2%8.5×18 +27.6%
6Shanghai Jiao Tong UniversityChina 54.419.2%2.8×28 -13.7%
7Sichuan UniversityChina 53.120.1%2.1×17 +43.9%
8Jilin UniversityChina 53.131.4%2.8×12 -13.8%
9Chengdu University of Traditional Chinese MedicineChina 53.119.8%11.5×10 +161.2%
10Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 52.317.6%4.2×16 +56.2%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Advanced Glycation End Products research, country by country

Is Advanced Glycation End Products research research growing?

Output in 2022-2025 was 0% higher than in 2018-2021, peaking in 2025. The fastest-growing topics are Advanced Glycation End Products research.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Advanced Glycation End Products research as a percentage of every work published that year, 0.017% in 2024.

still counting0.010%0.020%0.030%Advanced Glycation End Products research0.017% in 202519801990200020102020

Fractional works of Advanced Glycation End Products research over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Advanced Glycation End Products research10.2% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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