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Company · Burlington · United States

Arqule (United States)

arqule.comROR OpenAlex
World rank, all time
#32,807
of 34,923
Rank in United States
#6,886
of 7,310
Research works
222
▼ 69% vs 2018-21
Citations
5.7k
25.5 per fractional work
Top-10% rate
7.8%
all institutions 10.0%
vs its own fields
1.07×
1.00× is exactly expected
Open access
28%
world 40%
International
13%
world 18%
Arqule (United States)

Which fields of science does Arqule (United States) work in?

In all years, 38% of research at Arqule (United States) is in Physical Sciences, 34% in Life Sciences. Its largest fields are Chemistry (28%), Biochemistry, Genetics and Molecular Biology (28%), Medicine (17%). It does 2.1× the world's share of Life Sciences.

Physical Sciences: 84 fractional works · 38.0% of its workChemistry: 62 fractional works · 27.8% of its workOrganic Chemistry: 45 fractional works · 20.1% of its workSpectroscopy: 10 fractional works · 4.3% of its workAnalytical Chemistry: 3 fractional works · 1.4% of its workInorganic Chemistry: 3 fractional works · 1.4% of its workPhysical and Theoretical Chemistry: 1 fractional works · 0.6% of its workEngineering: 8 fractional works · 3.7% of its workBiomedical Engineering: 6 fractional works · 2.7% of its workElectrical and Electronic Engineering: 1 fractional works · 0.4% of its workControl and Systems Engineering: 0 fractional works · 0.2% of its workSmaller subfields together: 1 fractional works · 0.5% of its workComputer Science: 8 fractional works · 3.7% of its workComputational Theory and Mathematics: 5 fractional works · 2.4% of its workInformation Systems: 2 fractional works · 0.9% of its workSmaller subfields together: 1 fractional works · 0.4% of its workEnvironmental Science: 3 fractional works · 1.5% of its workEnvironmental Chemistry: 2 fractional works · 0.8% of its workEnvironmental Engineering: 0 fractional works · 0.2% of its workHealth, Toxicology and Mutagenesis: 0 fractional works · 0.2% of its workSmaller subfields together: 1 fractional works · 0.3% of its workMaterials Science: 1 fractional works · 0.6% of its workMaterials Chemistry: 1 fractional works · 0.5% of its workSmaller subfields together: 0 fractional works · 0.1% of its workEarth and Planetary Sciences: 1 fractional works · 0.4% of its workAtmospheric Science: 1 fractional works · 0.3% of its workSmaller subfields together: 0 fractional works · 0.1% of its workPhysics and Astronomy: 0 fractional works · 0.2% of its workLife Sciences: 75 fractional works · 33.9% of its workBiochemistry, Genetics and Molecular Biology: 61 fractional works · 27.5% of its workMolecular Biology: 52 fractional works · 23.3% of its workCancer Research: 3 fractional works · 1.2% of its workCell Biology: 2 fractional works · 1.0% of its workGenetics: 1 fractional works · 0.6% of its workBiotechnology: 1 fractional works · 0.5% of its workBiophysics: 1 fractional works · 0.4% of its workBiochemistry: 1 fractional works · 0.3% of its workPharmacology, Toxicology and Pharmaceutics: 10 fractional works · 4.4% of its workPharmacology: 5 fractional works · 2.3% of its workToxicology: 4 fractional works · 1.6% of its workPharmaceutical Science: 1 fractional works · 0.5% of its workImmunology and Microbiology: 2 fractional works · 1.1% of its workImmunology: 2 fractional works · 0.9% of its workSmaller subfields together: 1 fractional works · 0.2% of its workAgricultural and Biological Sciences: 1 fractional works · 0.5% of its workNeuroscience: 1 fractional works · 0.4% of its workCellular and Molecular Neuroscience: 1 fractional works · 0.3% of its workSmaller subfields together: 0 fractional works · 0.1% of its workHealth Sciences: 39 fractional works · 17.4% of its workMedicine: 38 fractional works · 16.9% of its workOncology: 7 fractional works · 3.3% of its workPulmonary and Respiratory Medicine: 5 fractional works · 2.3% of its workGenetics: 5 fractional works · 2.1% of its workHepatology: 3 fractional works · 1.5% of its workPathology and Forensic Medicine: 3 fractional works · 1.3% of its workPharmacology: 3 fractional works · 1.1% of its workRadiology, Nuclear Medicine and Imaging: 2 fractional works · 1.0% of its workHematology: 2 fractional works · 0.9% of its workPhysiology: 2 fractional works · 0.7% of its workSurgery: 1 fractional works · 0.6% of its workInfectious Diseases: 1 fractional works · 0.4% of its workPublic Health, Environmental and Occupational Health: 1 fractional works · 0.4% of its workEpidemiology: 1 fractional works · 0.3% of its workReproductive Medicine: 0 fractional works · 0.2% of its workRheumatology: 0 fractional works · 0.2% of its workPediatrics, Perinatology and Child Health: 0 fractional works · 0.2% of its workSmaller subfields together: 1 fractional works · 0.5% of its workHealth Professions: 1 fractional works · 0.5% of its workSocial Sciences: 24 fractional works · 10.6% of its workSocial Sciences: 12 fractional works · 5.3% of its workUrban Studies: 4 fractional works · 1.6% of its workSociology and Political Science: 2 fractional works · 0.9% of its workEducation: 2 fractional works · 0.7% of its workSafety Research: 1 fractional works · 0.6% of its workDevelopment: 1 fractional works · 0.5% of its workPolitical Science and International Relations: 0 fractional works · 0.2% of its workSmaller subfields together: 2 fractional works · 0.7% of its workArts and Humanities: 7 fractional works · 3.2% of its workArcheology: 4 fractional works · 1.6% of its workLiterature and Literary Theory: 1 fractional works · 0.5% of its workConservation: 1 fractional works · 0.3% of its workPhilosophy: 1 fractional works · 0.2% of its workVisual Arts and Performing Arts: 0 fractional works · 0.2% of its workSmaller subfields together: 1 fractional works · 0.4% of its workBusiness, Management and Accounting: 2 fractional works · 0.9% of its workOrganizational Behavior and Human Resource Management: 1 fractional works · 0.5% of its workManagement Information Systems: 1 fractional works · 0.3% of its workSmaller subfields together: 0 fractional works · 0.1% of its workPsychology: 1 fractional works · 0.5% of its workClinical Psychology: 1 fractional works · 0.5% of its workSmaller subfields together: 0 fractional works · 0.1% of its workDecision Sciences: 1 fractional works · 0.4% of its workManagement Science and Operations Research: 0 fractional works · 0.2% of its workSmaller subfields together: 0 fractional works · 0.2% of its workEconomics, Econometrics and Finance: 1 fractional works · 0.3% of its workEconomics and Econometrics: 0 fractional works · 0.2% of its workSmaller subfields together: 0 fractional works · 0.1% of its workALL ITS WORKArqule (UnitedStates)222fractional works, all years
Life Sciences34%Physical Sciences38%Health Sciences17%Social Sciences11%

Each ring splits the one inside it: the four domains of science, their fields, their subfields. Size is fractional works in all years. Every slice is a page; the interactive view zooms down to single topics and colours each by how much more of it this institution does than the world.

Its 4 domains and 20 fields, with their numbers
    1. Chemistry6227.8%
    2. Engineering83.7%
    3. Computer Science83.7%
    4. Environmental Science31.5%
    5. Materials Science10.6%
    6. Earth and Planetary Sciences10.4%
    7. Physics and Astronomy00.2%
    1. Biochemistry, Genetics and Molecular Biology6127.5%
    2. Pharmacology, Toxicology and Pharmaceutics104.4%
    3. Immunology and Microbiology21.1%
    4. Agricultural and Biological Sciences10.5%
    5. Neuroscience10.4%
    1. Medicine3816.9%
    2. Health Professions10.5%
    1. Social Sciences125.3%
    2. Arts and Humanities73.2%
    3. Business, Management and Accounting20.9%
    4. Psychology10.5%
    5. Decision Sciences10.4%
    6. Economics, Econometrics and Finance10.3%
All of science, and how each field's share has moved since 1950: the Science domain explorer

Field profile

Location quotient across every field it publishes in: outside the ring is more than an institution of this size would be expected to publish, inside it is less.

Agricultural and Biological Sciences: 0.30× its world share, 0 worksAgricultural and Bio…Biochemistry, Genetics and Molecular Biology: 0.18× its world share, 0 worksBiochemistry, Geneti…Computer Science: 1.67× its world share, 2 worksComputer ScienceEngineering: 0.19× its world share, 0 worksEngineeringEnvironmental Science: 1.16× its world share, 1 worksEnvironmental ScienceMaterials Science: 0.21× its world share, 0 worksMaterials ScienceMedicine: 0.14× its world share, 0 worksMedicineArts and Humanities: 6.50× its world share, 2 worksArts and HumanitiesBusiness, Management and Accounting: 2.99× its world share, 1 worksBusiness, Management…Decision Sciences: 1.00× its world share, 0 worksDecision SciencesEconomics, Econometrics and Finance: 0.51× its world share, 0 worksEconomics, Econometr…Psychology: 1.94× its world share, 1 worksPsychologySocial Sciences: 2.86× its world share, 4 worksSocial Sciences1×world share
more than its size predictsabout as predictedless

Rings at 0.5×, 1× and 2×. Widest outward: Arts and Humanities, 6.5×. Every wedge is a field page.

All 13 fields, with their numbers
  1. Arts and Humanities6.50×2 works
  2. Business, Management and Accounting2.99×1 works
  3. Social Sciences2.86×4 works
  4. Psychology1.94×1 works
  5. Computer Science1.67×2 works
  6. Environmental Science1.16×1 works
  7. Decision Sciences1.00×0 works
  8. Economics, Econometrics and Finance0.51×0 works
  9. Agricultural and Biological Sciences0.30×0 works
  10. Materials Science0.21×0 works
  11. Engineering0.19×0 works
  12. Biochemistry, Genetics and Molecular Biology0.18×0 works
  13. Medicine0.14×0 works

Who are the top researchers at Arqule (United States)?

Ranked on the quality score, Brian E. Schwartz, Sudharshan Eathiraj and Ronald E. Savage lead among researchers whose main affiliation is Arqule (United States).

  1. 1 Brian E. Schwartz United States · #72,348 worldwide 20k citations · 198 works
  2. 2 Sudharshan Eathiraj United States · #483,378 worldwide 2.2k citations · 79 works
  3. 3 Ronald E. Savage United States · #512,397 worldwide 1.8k citations · 60 works
  4. 4 Carol G. Waghorne United States · #896,268 worldwide 2.4k citations · 34 works
  5. 5 Chang-Rung Chen United States · #1,274,962 worldwide 2.8k citations · 35 works
  6. 6 Libing Yu United States · #1,283,950 worldwide 2.1k citations · 93 works
  7. 7 Terence G. Hall United States · #1,363,466 worldwide 831 citations · 30 works
  8. 8 Maria E. Lamar United States · #1,563,199 worldwide 1.3k citations · 23 works
  9. 9 Sapna Makhija United States · #1,586,892 worldwide 852 citations · 16 works
  10. 10 Dennis S. France United States · #1,587,532 worldwide 3.4k citations · 82 works
All ranked researchers at Arqule (United States)

What are the most cited papers from Arqule (United States)?

The most cited paper from Arqule (United States) is "Towards a proteome-scale map of the human protein–protein interaction network" (Jean‐François Rual et al., 2005), with 3,034 citations. Next come "Tivantinib for second-line treatment of advanced hepatocellular carcinoma: a randomised, placebo-controlled phase 2 study" (558) and "Derazantinib (ARQ 087) in advanced or inoperable FGFR2 gene fusion-positive intrahepatic cholangiocarcinoma" (385).

Most cited papers
#PaperReleasedCitations
1 Towards a proteome-scale map of the human protein–protein interaction network Jean‐François Rual et al. · Nature 27 Sep 2005 3,034
2 Tivantinib for second-line treatment of advanced hepatocellular carcinoma: a randomised, placebo-controlled phase 2 study Armando Santoro et al. · The Lancet Oncology 19 Nov 2012 558
3 Derazantinib (ARQ 087) in advanced or inoperable FGFR2 gene fusion-positive intrahepatic cholangiocarcinoma Vincenzo Mazzaferro, Bassel F. El‐Rayes, Michele Droz Dit Busset et al. · British Journal of Cancer Open access 7 Nov 2018 385
4 Tivantinib for second-line treatment of MET-high, advanced hepatocellular carcinoma (METIV-HCC): a final analysis of a phase 3, randomised, placebo-controlled study Lorenza Rimassa et al. · The Lancet Oncology 3 Apr 2018 356
5 The effect of tobacco cessation on weight gain, obesity, and diabetes risk Terry M. Bush, Jennifer C. Lovejoy, Mona Deprey et al. · Obesity Open access 29 Aug 2016 231
All 60 most cited papers, with filters and sorting

Which keywords describe research at Arqule (United States)?

By fractional works in all years, weighted toward what it does more of than the world: Drug Discovery, Synthesis, Medicinal Chemistry, Cancer, Anticancer Agents, Biological Evaluation, Signaling and Green Chemistry.

▲ more of its work than of the world's◆ about the world's share▼ less than the world's

Size is fractional works in all years in the topics tagged with each word; colour is the word's share of this institution's work against its share of the world's. The 40 words are chosen for being large and distinctive. Each links to the topic it comes from most.

All 40 words, with their numbers
  1. Drug Discovery27▲ 30×9 topics
  2. Synthesis20▲ 15×14 topics
  3. Medicinal Chemistry18▲ 22×9 topics
  4. Cancer17▲ 5.4×16 topics
  5. Anticancer Agents13▲ 23×7 topics
  6. Biological Evaluation13▲ 46×5 topics
  7. Green Chemistry12▲ 18×7 topics
  8. Signaling12▲ 47×4 topics
  9. Metabolism12▲ 8.2×4 topics
  10. Protein-Protein Interactions12▲ 49×2 topics
  11. Anticancer11▲ 25×5 topics
  12. Foldamers11▲ 62×1 topic
  13. Peptide Synthesis11▲ 62×1 topic
  14. Antimicrobial10▲ 17×3 topics
  15. Heterocyclic Compounds10▲ 28×4 topics
  16. Catalysis10▲ 5.2×5 topics
  17. Organic Synthesis10▲ 20×4 topics
  18. Molecular Docking9▲ 30×3 topics
  19. Asymmetric Synthesis9▲ 27×5 topics
  20. Pharmacokinetics9▲ 14×2 topics
  21. Alkaloids8▲ 51×4 topics
  22. Antimicrobial Activity8▲ 18×4 topics
  23. Chemotherapy8▲ 4.8×10 topics
  24. Cancer Therapy7▲ 5.3×12 topics
  25. Liquid Chromatography7▲ 21×2 topics
  26. Therapy7▲ 14×2 topics
  27. Chiral Separation7▲ 25×1 topic
  28. Gas Chromatography7▲ 25×1 topic
  29. Receptor7▲ 42×2 topics
  30. Cell Growth6▲ 87×2 topics
  31. Development6▲ 8.6×2 topics
  32. FGF216▲ 182×1 topic
  33. Fibroblast Growth Factor6▲ 182×1 topic
  34. Anti-inflammatory6▲ 9.1×2 topics
  35. Multicomponent Reactions6▲ 49×2 topics
  36. Indirubin6▲ 187×1 topic
  37. Quinazoline6▲ 187×1 topic
  38. Toxicology6▲ 12×4 topics
  39. Drug Target Identification5▲ 35×1 topic
  40. Virtual Screening5▲ 35×1 topic

Which research topics does Arqule (United States) publish most on?

By volume in 2022-now: Ethics and Social Impacts of AI, Innovation, Sustainability, Human-Machine Systems, Law, Ethics, and AI Impact and Digital and Traditional Archives Management.

Ethics and Social Impacts of AI: 1 fractional worksInnovation, Sustainability, Human-Machine Systems: 1 fractional worksLaw, Ethics, and AI Impact1Law, Ethics, and AI Impact: 1 fractional worksDigital and Traditional …1Digital and Traditional Archives Management: 1 fractional worksDigital Humanities and S…1Digital Humanities and Scholarship: 1 fractional worksResearch Data Management…1Research Data Management Practices: 1 fractional worksEducational Innovations and Technology: 0 fractional worksKnowledge Management in Higher Education: 0 fractional worksUrban and spatial planning: 0 fractional worksScientific Research and Technology: 0 fractional works
Safety ResearchSociology and Political ScienceOrganizational Behavior and Human Resource ManagementConservation5 others

Area is fractional works; colour is the subfield each topic belongs to.

  1. 1 Ethics and Social Impacts of AI Safety Research 1 works
  2. 2 Innovation, Sustainability, Human-Machine Systems Sociology and Political Science 1 works
  3. 3 Law, Ethics, and AI Impact Organizational Behavior and Human Resource Management 1 works
  4. 4 Digital and Traditional Archives Management Conservation 1 works
  5. 5 Digital Humanities and Scholarship Literature and Literary Theory 1 works
  6. 6 Research Data Management Practices Information Systems 1 works
  7. 7 Educational Innovations and Technology Information Systems 0 works
  8. 8 Knowledge Management in Higher Education Education 0 works
  9. 9 Urban and spatial planning Nature and Landscape Conservation 0 works
  10. 10 Scientific Research and Technology Computer Science Applications 0 works

How open and international is its research?

Against the world's own shares: the tick on each track. Both are shares of its output, so they sit on one scale and can be read against each other as well as against the world.

openly available27.9%not open72.1%

World: 40% of research is openly available.

with international co-authors13.0%domestic only87.0%

World: 18% is written across borders.

How has Arqule (United States)'s research output changed?

Output in 2022-2025 was 69% lower than in 2018-2021.

still counting1990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Arqule (United States) as a percentage of every work published that year, 0.000027% in 2024.

still counting0.00050%0.0010%0.0015%Arqule (United States)0.000026% in 202519801990200020102020

Fractional works of Arqule (United States) over all fractional works that year. How the balance of science has shifted.

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Arqule (United States) on Science Explorer

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