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Company · Cambridge · United States

Epizyme (United States)

epizyme.comROR OpenAlex
World rank, all time
#34,176
of 34,923
Rank in United States
#7,178
of 7,310
Research works
131
▼ 63% vs 2018-21
Citations
8.9k
68.5 per fractional work
Top-10% rate
5.2%
all institutions 10.0%
vs its own fields
1.13×
1.00× is exactly expected
Open access
30%
world 40%
International
14%
world 18%
Epizyme (United States)

Which fields of science does Epizyme (United States) work in?

In all years, 75% of research at Epizyme (United States) is in Life Sciences, 20% in Health Sciences. Its largest fields are Biochemistry, Genetics and Molecular Biology (72%), Medicine (20%), Computer Science (2%). It does 4.5× the world's share of Life Sciences.

Life Sciences: 98 fractional works · 75.1% of its workBiochemistry, Genetics and Molecular Biology: 95 fractional works · 72.4% of its workMolecular Biology: 90 fractional works · 69.0% of its workCancer Research: 2 fractional works · 1.8% of its workGenetics: 1 fractional works · 1.1% of its workSmaller subfields together: 1 fractional works · 0.4% of its workPharmacology, Toxicology and Pharmaceutics: 2 fractional works · 1.8% of its workPharmacology: 2 fractional works · 1.4% of its workPharmaceutical Science: 1 fractional works · 0.4% of its workImmunology and Microbiology: 1 fractional works · 0.6% of its workImmunology: 1 fractional works · 0.4% of its workSmaller subfields together: 0 fractional works · 0.2% of its workAgricultural and Biological Sciences: 0 fractional works · 0.3% of its workAgronomy and Crop Science: 0 fractional works · 0.3% of its workNeuroscience: 0 fractional works · 0.1% of its workHealth Sciences: 26 fractional works · 19.9% of its workMedicine: 26 fractional works · 19.8% of its workPathology and Forensic Medicine: 6 fractional works · 4.8% of its workHematology: 6 fractional works · 4.3% of its workOncology: 4 fractional works · 3.2% of its workPulmonary and Respiratory Medicine: 2 fractional works · 1.7% of its workGenetics: 2 fractional works · 1.5% of its workPublic Health, Environmental and Occupational Health: 1 fractional works · 0.9% of its workPediatrics, Perinatology and Child Health: 1 fractional works · 0.6% of its workRadiology, Nuclear Medicine and Imaging: 1 fractional works · 0.5% of its workSurgery: 1 fractional works · 0.4% of its workEpidemiology: 0 fractional works · 0.3% of its workInfectious Diseases: 0 fractional works · 0.3% of its workEndocrinology, Diabetes and Metabolism: 0 fractional works · 0.3% of its workRheumatology: 0 fractional works · 0.3% of its workSmaller subfields together: 1 fractional works · 0.7% of its workNursing: 0 fractional works · 0.1% of its workPhysical Sciences: 6 fractional works · 4.6% of its workComputer Science: 3 fractional works · 2.1% of its workComputational Theory and Mathematics: 3 fractional works · 2.1% of its workChemistry: 2 fractional works · 1.8% of its workOrganic Chemistry: 2 fractional works · 1.4% of its workSpectroscopy: 0 fractional works · 0.3% of its workSmaller subfields together: 0 fractional works · 0.1% of its workEnvironmental Science: 0 fractional works · 0.3% of its workEcology: 0 fractional works · 0.3% of its workEngineering: 0 fractional works · 0.3% of its workBiomedical Engineering: 0 fractional works · 0.3% of its workSocial Sciences: 1 fractional works · 0.5% of its workEconomics, Econometrics and Finance: 0 fractional works · 0.3% of its workEconomics and Econometrics: 0 fractional works · 0.3% of its workSmaller subfields together: 0 fractional works · 0.0% of its workBusiness, Management and Accounting: 0 fractional works · 0.1% of its workSocial Sciences: 0 fractional works · 0.1% of its workALL ITS WORKEpizyme (UnitedStates)131fractional works, all years
Life Sciences75%Physical Sciences5%Health Sciences20%Social Sciences0%

Each ring splits the one inside it: the four domains of science, their fields, their subfields. Size is fractional works in all years. Every slice is a page; the interactive view zooms down to single topics and colours each by how much more of it this institution does than the world.

Its 4 domains and 14 fields, with their numbers
    1. Biochemistry, Genetics and Molecular Biology9572.4%
    2. Pharmacology, Toxicology and Pharmaceutics21.8%
    3. Immunology and Microbiology10.6%
    4. Agricultural and Biological Sciences00.3%
    5. Neuroscience00.1%
    1. Medicine2619.8%
    2. Nursing00.1%
    1. Computer Science32.1%
    2. Chemistry21.8%
    3. Environmental Science00.3%
    4. Engineering00.3%
    1. Economics, Econometrics and Finance00.3%
    2. Business, Management and Accounting00.1%
    3. Social Sciences00.1%
All of science, and how each field's share has moved since 1950: the Science domain explorer

Field profile

Location quotient across every field it publishes in: outside the ring is more than an institution of this size would be expected to publish, inside it is less.

Agricultural and Biological Sciences: 0.78× its world share, 0 worksAgricultural and Bio…Biochemistry, Genetics and Molecular Biology: 9.31× its world share, 4 worksBiochemistry, Geneti…Immunology and Microbiology: 2.22× its world share, 0 worksImmunology and Micro…Pharmacology, Toxicology and Pharmaceutics: 2.11× its world share, 0 worksPharmacology, Toxico…Chemistry: 1.34× its world share, 0 worksChemistryEngineering: 0.25× its world share, 0 worksEngineeringEnvironmental Science: 1.00× its world share, 0 worksEnvironmental ScienceMedicine: 1.59× its world share, 3 worksMedicineEconomics, Econometrics and Finance: 1.04× its world share, 0 worksEconomics, Econometr…1×world share
more than its size predictsabout as predictedless

Rings at 0.5×, 1× and 2×. Widest outward: Biochemistry, Genetics and Molecular Biology, 9.3×. Every wedge is a field page.

All 9 fields, with their numbers
  1. Biochemistry, Genetics and Molecular Biology9.31×4 works
  2. Immunology and Microbiology2.22×0 works
  3. Pharmacology, Toxicology and Pharmaceutics2.11×0 works
  4. Medicine1.59×3 works
  5. Chemistry1.34×0 works
  6. Economics, Econometrics and Finance1.04×0 works
  7. Environmental Science1.00×0 works
  8. Agricultural and Biological Sciences0.78×0 works
  9. Engineering0.25×0 works

Who are the top researchers at Epizyme (United States)?

Ranked on the quality score, Nigel J. Waters, Lei Jin and Roy M. Pollock lead among researchers whose main affiliation is Epizyme (United States).

  1. 1 Nigel J. Waters United States · #82,130 worldwide 6.7k citations · 108 works
  2. 2 Lei Jin United States · #84,743 worldwide 10k citations · 90 works
  3. 3 Roy M. Pollock United States · #102,135 worldwide 12k citations · 116 works
  4. 4 Robert A. Copeland United States · #115,456 worldwide 11k citations · 105 works
  5. 5 Mikel P. Moyer United States · #115,664 worldwide 6.7k citations · 52 works
  6. 6 Richard Chesworth United States · #136,522 worldwide 6.9k citations · 81 works
  7. 7 Heike Keilhack United States · #157,873 worldwide 7k citations · 119 works
  8. 8 Margaret Porter Scott United States · #162,506 worldwide 7.7k citations · 52 works
  9. 9 Scott A. Ribich United States · #173,789 worldwide 5.6k citations · 137 works
  10. 10 Sarah K. Knutson United States · #174,689 worldwide 5.4k citations · 64 works
All ranked researchers at Epizyme (United States)

What are the most cited papers from Epizyme (United States)?

The most cited paper from Epizyme (United States) is "Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor" (Scott R. Daigle et al., 2011), with 944 citations. Next come "MLL-Rearranged Leukemia Is Dependent on Aberrant H3K79 Methylation by DOT1L" (907) and "The promise and peril of chemical probes" (864).

Most cited papers
#PaperReleasedCitations
1 Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor Scott R. Daigle et al. · Cancer Cell Open access Jul 2011 944
2 MLL-Rearranged Leukemia Is Dependent on Aberrant H3K79 Methylation by DOT1L Kathrin M. Bernt, Nan Zhu, Amit U. Sinha et al. · Cancer Cell Open access Jul 2011 907
3 The promise and peril of chemical probes C.H. Arrowsmith et al. · Nature Chemical Biology Open access 21 Jul 2015 864
4 Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2 Sarah K. Knutson, Natalie M. Warholic, Tim J. Wigle et al. · Proceedings of the National Academy of Sciences Open access 25 Apr 2013 803
5 A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells Sarah K. Knutson et al. · Nature Chemical Biology 30 Sep 2012 770
All 60 most cited papers, with filters and sorting

Which keywords describe research at Epizyme (United States)?

By fractional works in all years, weighted toward what it does more of than the world: Cancer, Transcriptional Regulation, Epigenetic Regulation, Cell Proliferation, Arginine Methylation, Protein Arginine Methyltransferases, DNA Methylation and Epigenetic Reprogramming.

▲ more of its work than of the world's◆ about the world's share▼ less than the world's

Size is fractional works in all years in the topics tagged with each word; colour is the word's share of this institution's work against its share of the world's. The 40 words are chosen for being large and distinctive. Each links to the topic it comes from most.

All 40 words, with their numbers
  1. Cancer37▲ 20×10 topics
  2. Transcriptional Regulation37▲ 113×5 topics
  3. Epigenetic Regulation34▲ 120×3 topics
  4. Cell Proliferation30▲ 255×2 topics
  5. Arginine Methylation30▲ 698×1 topic
  6. Protein Arginine Methyltransferases30▲ 698×1 topic
  7. DNA Methylation24▲ 161×2 topics
  8. Epigenetic Reprogramming24▲ 237×1 topic
  9. Histone Modification24▲ 285×1 topic
  10. Cancer Progression10▲ 32×4 topics
  11. Gene Expression Regulation8▲ 53×3 topics
  12. Epigenetics8▲ 100×2 topics
  13. Prognostic Factors8▲ 13×8 topics
  14. RNA methylation7▲ 68×1 topic
  15. m6A-seq7▲ 68×1 topic
  16. BET Bromodomains7▲ 266×1 topic
  17. PROTACs7▲ 266×1 topic
  18. Synthetic Lethality7▲ 211×2 topics
  19. Cancer Therapy7▲ 8.1×7 topics
  20. Tumor Suppressor7▲ 125×3 topics
  21. Chromatin Remodeling6▲ 624×1 topic
  22. Genomic Analysis6▲ 17×2 topics
  23. SWI/SNF Complexes6▲ 624×1 topic
  24. AML5▲ 78×1 topic
  25. Acute Myeloid Leukemia5▲ 78×1 topic
  26. Pharmacokinetics4▲ 13×2 topics
  27. Gene Expression4▲ 5.3×5 topics
  28. Rituximab4▲ 20×2 topics
  29. HDAC Inhibitors4▲ 160×1 topic
  30. Histone Deacetylases4▲ 160×1 topic
  31. Medicinal Chemistry4▲ 8.0×3 topics
  32. PET Imaging4▲ 14×3 topics
  33. Lymphoma4▲ 18×2 topics
  34. Classification3▲ 6.7×1 topic
  35. Molecular Profiling3▲ 20×1 topic
  36. Targeted Therapy3▲ 10×3 topics
  37. Molecular Docking3▲ 15×1 topic
  38. Phosphorylation3▲ 77×2 topics
  39. Virtual Screening3▲ 30×1 topic
  40. Tumorigenesis3▲ 37×2 topics

Which research topics does Epizyme (United States) publish most on?

By volume in 2022-now: Cancer-related gene regulation, Epigenetics and DNA Methylation, Lymphoma Diagnosis and Treatment and Dermatological and Skeletal Disorders.

Cancer-related gene regulation: 1 fractional worksEpigenetics and DNA Methylation: 1 fractional worksLymphoma Diagnosis and Treatment: 0 fractional worksDermatological and Skeletal Disorders: 0 fractional worksProtein Degradation and Inhibitors: 0 fractional worksCancer Genomics and Diagnostics: 0 fractional worksBacteriophages and micro…0Bacteriophages and microbial interactions: 0 fractional worksHeterotopic Ossification and Related Conditions: 0 fractional worksBiosensors and Analytical Detection: 0 fractional worksAnimal Disease Management and Epidemiology: 0 fractional works
Molecular BiologyPathology and Forensic MedicineGeneticsCancer Research4 others

Area is fractional works; colour is the subfield each topic belongs to.

  1. 1 Cancer-related gene regulation Molecular Biology 1 works
  2. 2 Epigenetics and DNA Methylation Molecular Biology 1 works
  3. 3 Lymphoma Diagnosis and Treatment Pathology and Forensic Medicine 0 works
  4. 4 Dermatological and Skeletal Disorders Genetics 0 works
  5. 5 Protein Degradation and Inhibitors Molecular Biology 0 works
  6. 6 Cancer Genomics and Diagnostics Cancer Research 0 works
  7. 7 Bacteriophages and microbial interactions Ecology 0 works
  8. 8 Heterotopic Ossification and Related Conditions Rheumatology 0 works
  9. 9 Biosensors and Analytical Detection Biomedical Engineering 0 works
  10. 10 Animal Disease Management and Epidemiology Agronomy and Crop Science 0 works

How open and international is its research?

Against the world's own shares: the tick on each track. Both are shares of its output, so they sit on one scale and can be read against each other as well as against the world.

openly available30.3%not open69.7%

World: 40% of research is openly available.

with international co-authors13.8%domestic only86.2%

World: 18% is written across borders.

How has Epizyme (United States)'s research output changed?

Output in 2022-2025 was 63% lower than in 2018-2021.

still counting200020052010201520202025
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Epizyme (United States) as a percentage of every work published that year, 0.000044% in 2023.

0.00050%0.0010%Epizyme (United States)0.000033% in 2024200020102020

Fractional works of Epizyme (United States) over all fractional works that year. How the balance of science has shifted.

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Epizyme (United States) on Science Explorer

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