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Topic · Rheumatology

Heterotopic Ossification and Related Conditions

Heterotopic Ossification and Related Conditions is a research topic within Rheumatology. Science Explorer counts 6.9k research works in it since 1950. 10.2% of them reached the world's top 10% most cited for their field and year.

This cluster of papers focuses on the topic of heterotopic ossification, particularly in the context of fibrodysplasia ossificans progressiva (FOP). It covers various aspects including the role of BMP type I receptor mutations, progenitor cells, pathophysiology, prevention strategies, and the impact of traumatic injuries. Additionally, it explores the use of radiation therapy as a prophylactic measure.

  • Heterotopic Ossification
  • Fibrodysplasia Ossificans Progressiva
  • BMP Type I Receptor
  • ACVR1 Mutation
  • Progenitor Cells
  • Inhibition
  • Pathophysiology
  • Prevention
  • Traumatic Injury
  • Radiation Therapy
Research works
6.9k
fractional, since 1950
In the world top 10%
699
per year above
Top-10% rate
10.2%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
+6%
the tick is no change
Largest producer
United States
30% of the 10 largest, 2022-now
Heterotopic Ossification and Related Conditions

This ranks research output and citation impact. It says nothing about the quality of diagnosis, treatment or care.

Which countries lead Heterotopic Ossification and Related Conditions research?

By volume, the United States and China publish the most (326 and 264 works in 2022-now).

By volume, 2022-now

  1. 1 United States 326 works
  2. 2 China 264 works
  3. 3 India 115 works
  4. 4 Japan 95 works
  5. 5 Germany 58 works
  6. 6 United Kingdom 56 works
  7. 7 France 44 works
  8. 8 Italy 42 works
  9. 9 Spain 36 works
  10. 10 South Korea 36 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

United States: 30.4%China: 24.6%India: 10.8%Japan: 8.9%6 others listed: 25.3%30%largest
United States326 · 30.4%China264 · 24.6%India115 · 10.8%Japan95 · 8.9%6 others listed272 · 25.3%

Shares of the rows listed above, not of the whole node.

Which institutions lead Heterotopic Ossification and Related Conditions research?

By volume in 2022-now, Harvard University publishes the most Heterotopic Ossification and Related Conditions research, followed by All India Institute of Medical Sciences and Peking University.

By volume, 2022-now

  1. 1 Harvard UniversityUnited States 14 works
  2. 2 All India Institute of Medical SciencesIndia 13 works
  3. 3 Peking UniversityChina 13 works
  4. 4 Shanghai Jiao Tong UniversityChina 13 works
  5. 5 Sichuan UniversityChina 11 works
  6. 6 Mayo ClinicUnited States 11 works
  7. 7 University of PennsylvaniaUnited States 8 works
  8. 8 The University of Texas Southwestern Medical CenterUnited States 7 works
  9. 9 University of MichiganUnited States 6 works
  10. 10 Capital Medical UniversityChina 6 works

Who are the leading researchers in Heterotopic Ossification and Related Conditions?

The most-cited researchers publishing on Heterotopic Ossification and Related Conditions include Cyrus Cooper, Gordon Henry Guyatt and André Gerardus Uitterlinden.

  1. 1 Cyrus Cooper United Kingdom 342k citations
  2. 2 Gordon Henry Guyatt Canada 315k citations
  3. 3 André Gerardus Uitterlinden Netherlands 246k citations
  4. 4 Ziyad Al‐Aly United States 177k citations
  5. 5 George D. Yancopoulos United States 168k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Heterotopic Ossification and Related Conditions?

The most cited paper in Heterotopic Ossification and Related Conditions is "Ectopic Ossification Following Total Hip Replacement" (Andrew F. Brooker, Jack W. Bowerman, Robert Anthony Robinson et al., 1973), with 2,819 citations. Next come "Ectopic Ossification Following Total Hip Replacement: Incidence and a Method of Classification" (2,548) and "SB-431542 Is a Potent and Specific Inhibitor of Transforming Growth Factor-β Superfamily Type I Activin Receptor-Like Kinase (ALK) Receptors ALK4, ALK5, and ALK7" (1,670).

Most cited papers
#PaperReleasedCitations
1 Ectopic Ossification Following Total Hip Replacement Andrew F. Brooker, Jack W. Bowerman, Robert Anthony Robinson et al. · Journal of Bone and Joint Surgery Dec 1973 2,819
2 Ectopic Ossification Following Total Hip Replacement: Incidence and a Method of Classification Paul A. Banaszkiewicz Book chapter 7 Dec 2013 2,548
3 SB-431542 Is a Potent and Specific Inhibitor of Transforming Growth Factor-β Superfamily Type I Activin Receptor-Like Kinase (ALK) Receptors ALK4, ALK5, and ALK7 Gareth J. Inman, Francisco José Nicolás, James F. Callahan et al. · Molecular Pharmacology Jul 2002 1,670
4 TGF-β and BMP signaling in osteoblast, skeletal development, and bone formation, homeostasis and disease Mengrui Wu, Guiqian Chen, Yiping Li · Bone Research Open access 26 Apr 2016 1,642
5 Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism Takashi Shimada, Makoto Kakitani, Y. Yamazaki et al. · Journal of Clinical Investigation Open access 15 Feb 2004 1,377
All 98 most cited papers, with filters and sorting

Where is Heterotopic Ossification and Related Conditions research done?

The largest centres of Heterotopic Ossification and Related Conditions research in 2022-now are Beijing (China), Shanghai (China), Tokyo (Japan) and London (United Kingdom).

Largest cities, 2022-now

  1. 1 BeijingChina 39 works
  2. 2 ShanghaiChina 27 works
  3. 3 TokyoJapan 20 works
  4. 4 LondonUnited Kingdom 18 works
  5. 5 ParisFrance 16 works
  6. 6 PhiladelphiaUnited States 16 works
  7. 7 ChengduChina 15 works
  8. 8 New YorkUnited States 14 works
  9. 9 GuangzhouChina 14 works
  10. 10 BostonUnited States 14 works
See Heterotopic Ossification and Related Conditions on the map

Where is the best place to study Heterotopic Ossification and Related Conditions?

Among universities, judged by research, Harvard University, Shanghai Jiao Tong University and Peking University score highest, combining citation excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%10%20%mean 12.86%fractional works in this field (log) →share of work in the world top 10% →Shanghai Jiao Tong U…Peking UniversityHarvard UniversityAll India Institute …
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Citation excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Harvard UniversityUnited States 87.09.6%3.5×14 +24.5%
2Shanghai Jiao Tong UniversityChina 73.923.6%3.6×13 +15.0%
3Peking UniversityChina 60.111.8%5.2×13 +29.5%
4All India Institute of Medical SciencesIndia 44.53.6%9.6×13 +80.4%
5Sichuan UniversityChina 35.015.7%4.0×11 +2.2%

Universities only. The score blends citation excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Heterotopic Ossification and Related Conditions, country by country

Is Heterotopic Ossification and Related Conditions research growing?

Output in 2022-2025 was 6% higher than in 2018-2021, peaking in 2025. The fastest-growing topics are Heterotopic Ossification and Related Conditions.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Heterotopic Ossification and Related Conditions as a percentage of every work published that year, 0.0053% in 2024.

still counting0.0050%0.010%Heterotopic Ossification and Related Conditions0.0057% in 202519801990200020102020

Fractional works of Heterotopic Ossification and Related Conditions over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Heterotopic Ossification and Related Conditions10.4% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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