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Topic · Rheumatology

Folate and B Vitamins Research

Folate and B Vitamins Research is a research topic within Rheumatology. Science Explorer counts 45k research works in it since 1950. 10.1% of them reached the world's top 10% most cited for their field and year.

This cluster of papers explores the role of homocysteine in various health conditions, including cardiovascular disease, neural tube defects, cognitive impairment, and endothelial dysfunction. It also investigates the impact of folate, vitamin B12, and one-carbon metabolism on homocysteine levels and associated diseases.

  • Homocysteine
  • Folate
  • Vitamin B12
  • Cardiovascular Disease
  • Neural Tube Defects
  • Methylation
  • One-Carbon Metabolism
  • Cognitive Impairment
  • Folic Acid
  • Endothelial Dysfunction
Research works
45k
fractional, since 1950
In the world top 10%
4.6k
per year above
Top-10% rate
10.1%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
+6%
the tick is no change
Largest producer
China
31% of the 10 largest, 2022-now
Folate and B Vitamins Research

This ranks research output and citation impact. It says nothing about the quality of diagnosis, treatment or care.

Which countries lead Folate and B Vitamins Research research?

By volume, China and the United States publish the most (1.4k and 1.4k works in 2022-now).

By volume, 2022-now

  1. 1 China 1.4k works
  2. 2 United States 1.4k works
  3. 3 India 445 works
  4. 4 United Kingdom 240 works
  5. 5 Japan 215 works
  6. 6 Brazil 197 works
  7. 7 Türkiye 175 works
  8. 8 Italy 166 works
  9. 9 Germany 138 works
  10. 10 Canada 138 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

China: 31.5%United States: 30.7%India: 9.8%United Kingdom: 5.3%6 others listed: 22.7%31%largest
China1,429 · 31.5%United States1,395 · 30.7%India445 · 9.8%United Kingdom240 · 5.3%6 others listed1,029 · 22.7%

Shares of the rows listed above, not of the whole node.

Which institutions lead Folate and B Vitamins Research research?

By volume in 2022-now, Harvard University publishes the most Folate and B Vitamins Research research, followed by Capital Medical University and Shanghai Jiao Tong University.

By volume, 2022-now

  1. 1 Harvard UniversityUnited States 50 works
  2. 2 Capital Medical UniversityChina 43 works
  3. 3 Shanghai Jiao Tong UniversityChina 35 works
  4. 4 Sun Yat-sen UniversityChina 34 works
  5. 5 Sichuan UniversityChina 33 works
  6. 6 Peking UniversityChina 33 works
  7. 7 Russian Academy of SciencesRussia 30 works
  8. 8 University of North Carolina at Chapel HillUnited States 30 works
  9. 9 All India Institute of Medical SciencesIndia 28 works
  10. 10 Nanjing Medical UniversityChina 27 works

Who are the leading researchers in Folate and B Vitamins Research?

The most-cited researchers publishing on Folate and B Vitamins Research include Douglas G. Altman, Christopher J L Murray and Simon Iain Hay.

  1. 1 Douglas G. Altman United Kingdom 862k citations
  2. 2 Christopher J L Murray United States 583k citations
  3. 3 Simon Iain Hay United States 452k citations
  4. 4 George Davey Smith United Kingdom 435k citations
  5. 5 Ali H. Mokdad United States 429k citations
  6. 6 Walter Churchill Willett United States 411k citations
  7. 7 Mark J. Daly United States 403k citations
  8. 8 Julian P. T. Higgins United Kingdom 390k citations
  9. 9 Guido Kroemer France 386k citations
  10. 10 Zulfiqar Ahmed Bhutta Pakistan 371k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Folate and B Vitamins Research?

The most cited paper in Folate and B Vitamins Research is "Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent" (Jozef Sedlak, Raymond H. Lindsay, 1968), with 8,107 citations. Next come "‘Mendelian randomization’: can genetic epidemiology contribute to understanding environmental determinants of disease?*" (6,495) and "A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase" (5,732).

Most cited papers
#PaperReleasedCitations
1 Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent Jozef Sedlak, Raymond H. Lindsay · Analytical Biochemistry 1968 8,107
2 ‘Mendelian randomization’: can genetic epidemiology contribute to understanding environmental determinants of disease?* George Davey Smith, Shah B J Ebrahim · International Journal of Epidemiology Feb 2003 6,495
3 A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase Phyllis Frosst, Henk J. Blom, Renate Milos et al. · Nature Genetics Open access May 1995 5,732
4 Mendelian randomization: genetic anchors for causal inference in epidemiological studies George Davey Smith, Gibran Hemani · Human Molecular Genetics Open access 4 Jul 2014 5,184
5 Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology Debbie A. Lawlor, Roger M. Harbord, Jonathan A C Sterne et al. · Statistics in Medicine 20 Sep 2007 5,071
All 100 most cited papers, with filters and sorting

Where is Folate and B Vitamins Research research done?

The largest centres of Folate and B Vitamins Research research in 2022-now are Beijing (China), Shanghai (China), Guangzhou (China) and London (United Kingdom).

Largest cities, 2022-now

  1. 1 BeijingChina 203 works
  2. 2 ShanghaiChina 98 works
  3. 3 GuangzhouChina 90 works
  4. 4 LondonUnited Kingdom 71 works
  5. 5 SeoulSouth Korea 62 works
  6. 6 HangzhouChina 55 works
  7. 7 New YorkUnited States 54 works
  8. 8 TokyoJapan 52 works
  9. 9 NanjingChina 51 works
  10. 10 ParisFrance 51 works
See Folate and B Vitamins Research on the map

Where is the best place to study Folate and B Vitamins Research?

Among universities, judged by research, Harvard University, Sun Yat-sen University and Capital Medical University score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%10%20%30%mean 15.46%fractional works in this field (log) →share of work in the world top 10% →University of Minnes…Harvard UniversitySun Yat-sen UniversityCapital Medical Univ…
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Harvard UniversityUnited States 80.316.4%2.7×50 -6.9%
2Sun Yat-sen UniversityChina 61.913.1%2.8×34 +69.4%
3Capital Medical UniversityChina 60.28.7%6.9×43 +23.7%
4University of MinnesotaUnited States 59.424.1%2.3×10 +55.0%
5Anhui Medical UniversityChina 58.515.0%7.7×21 +281.5%
6University of California, San FranciscoUnited States 58.114.0%3.8×16 +18.4%
7Peking UniversityChina 57.512.0%2.8×33 +7.8%
8Rutgers, The State University of New JerseyUnited States 57.320.3%2.7×12 -6.0%
9University of OxfordUnited Kingdom 56.821.0%1.1×10 -0.4%
10Shanghai Jiao Tong UniversityChina 56.310.0%2.1×35 +23.4%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Folate and B Vitamins Research, country by country

Is Folate and B Vitamins Research research growing?

Output in 2022-2025 was 6% higher than in 2018-2021, peaking in 2025. The fastest-growing topics are Folate and B Vitamins Research.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Folate and B Vitamins Research as a percentage of every work published that year, 0.026% in 2024.

still counting0.050%0.10%Folate and B Vitamins Research0.027% in 202519801990200020102020

Fractional works of Folate and B Vitamins Research over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Folate and B Vitamins Research10.2% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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