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Topic · Molecular Biology

Histone Deacetylase Inhibitors Research

Histone Deacetylase Inhibitors Research is a research topic within Molecular Biology. Science Explorer counts 21k research works in it since 1953. 10.1% of them reached the world's top 10% most cited for their field and year.

This cluster of papers explores the role of histone deacetylases (HDACs) in regulating cellular functions, gene expression, and epigenetic modifications. It covers the use of HDAC inhibitors in cancer therapy, their impact on neurodegenerative disorders, and their involvement in protein complexes and enzymatic activity.

  • Histone Deacetylases
  • HDAC Inhibitors
  • Epigenetic Regulation
  • Cancer Therapy
  • Cellular Functions
  • Acetylation
  • Gene Expression
  • Neurodegenerative Disorders
  • Protein Complexes
  • Enzymatic Activity
Research works
21k
fractional, since 1953
In the world top 10%
2.2k
per year above
Top-10% rate
10.1%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
+6%
the tick is no change
Largest producer
China
42% of the 10 largest, 2022-now
Histone Deacetylase Inhibitors Research

Which countries lead Histone Deacetylase Inhibitors Research research?

By volume, China and the United States publish the most (1.8k and 1.2k works in 2022-now).

By volume, 2022-now

  1. 1 China 1.8k works
  2. 2 United States 1.2k works
  3. 3 India 294 works
  4. 4 Germany 196 works
  5. 5 Italy 177 works
  6. 6 Japan 154 works
  7. 7 South Korea 152 works
  8. 8 United Kingdom 115 works
  9. 9 France 85 works
  10. 10 Canada 81 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

China: 42.0%United States: 28.3%India: 7.0%Germany: 4.6%6 others listed: 18.1%42%largest
China1,772 · 42.0%United States1,196 · 28.3%India294 · 7.0%Germany196 · 4.6%6 others listed765 · 18.1%

Shares of the rows listed above, not of the whole node.

Which institutions lead Histone Deacetylase Inhibitors Research research?

By volume in 2022-now, Harvard University publishes the most Histone Deacetylase Inhibitors Research research, followed by The University of Texas MD Anderson Cancer Center and Sun Yat-sen University.

By volume, 2022-now

  1. 1 Harvard UniversityUnited States 62 works
  2. 2 The University of Texas MD Anderson Cancer CenterUnited States 52 works
  3. 3 Sun Yat-sen UniversityChina 49 works
  4. 4 Sichuan UniversityChina 48 works
  5. 5 Zhejiang UniversityChina 42 works
  6. 6 Shanghai Jiao Tong UniversityChina 39 works
  7. 7 Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 38 works
  8. 8 Chinese Academy of SciencesChina 38 works
  9. 9 Zhengzhou UniversityChina 36 works
  10. 10 Soochow UniversityChina 31 works

Who are the leading researchers in Histone Deacetylase Inhibitors Research?

The most-cited researchers publishing on Histone Deacetylase Inhibitors Research include Zhong Lin Wang, Guido Kroemer and Bert Vogelstein.

  1. 1 Zhong Lin Wang United States 491k citations
  2. 2 Guido Kroemer France 386k citations
  3. 3 Bert Vogelstein United States 373k citations
  4. 4 Elaine R. Mardis United States 346k citations
  5. 5 Jun Wang China 340k citations
  6. 6 Matthias Mann Germany 308k citations
  7. 7 John Q. Trojanowski United States 286k citations
  8. 8 Todd R. Golub United States 283k citations
  9. 9 Matthew M. Meyerson United States 280k citations
  10. 10 Michael Karin United States 276k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Histone Deacetylase Inhibitors Research?

The most cited paper in Histone Deacetylase Inhibitors Research is "Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel" (Hartmut Döhner et al., 2016), with 5,972 citations. Next come "A simple method for clinical assay of superoxide dismutase." (4,529) and "The Epigenomics of Cancer" (4,489).

Most cited papers
#PaperReleasedCitations
1 Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel Hartmut Döhner et al. · Blood Open access 28 Nov 2016 5,972
2 A simple method for clinical assay of superoxide dismutase. Yi Sun, Larry W. Oberley, Yi Li · Clinical Chemistry Mar 1988 4,529
3 The Epigenomics of Cancer Peter Anthony Jones, Stephen B. Baylin · Cell Open access Feb 2007 4,489
4 Selective inhibition of BET bromodomains P. Filippakopoulos et al. · Nature Open access 24 Sep 2010 4,363
5 Cancer Metastasis: Building a Framework Gaorav P. Gupta, Joan Massagué · Cell Open access Nov 2006 4,346
All 100 most cited papers, with filters and sorting

Where is Histone Deacetylase Inhibitors Research research done?

The largest centres of Histone Deacetylase Inhibitors Research research in 2022-now are Beijing (China), Shanghai (China), Guangzhou (China) and Nanjing (China). Among places with at least 20 works in it, it is an unusually large share of all research in Houston.

Largest cities, 2022-now

  1. 1 BeijingChina 168 works
  2. 2 ShanghaiChina 135 works
  3. 3 GuangzhouChina 113 works
  4. 4 NanjingChina 85 works
  5. 5 HangzhouChina 77 works
  6. 6 HoustonUnited States 73 works
  7. 7 SeoulSouth Korea 68 works
  8. 8 ChengduChina 67 works
  9. 9 New YorkUnited States 61 works
  10. 10 WuhanChina 61 works

Where it is the local speciality

  1. HoustonUS · 72.5 works5.8×
← less than its size predicts1×more →

Location quotient: how much more of its research is in Histone Deacetylase Inhibitors Research than the world average.

See Histone Deacetylase Inhibitors Research on the map

Where is the best place to study Histone Deacetylase Inhibitors Research?

Among universities, judged by research, Harvard University, Sichuan University and Sun Yat-sen University score highest, combining citation excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%10%20%mean 16.43%fractional works in this field (log) →share of work in the world top 10% →China Medical Univer…Harvard UniversitySichuan UniversitySun Yat-sen University
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Citation excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Harvard UniversityUnited States 81.617.8%4.3×62 -13.9%
2Sichuan UniversityChina 74.916.9%4.7×48 +51.7%
3Sun Yat-sen UniversityChina 68.012.9%5.2×49 +36.5%
4China Medical UniversityChina 66.919.5%13.8×26 +43.7%
5China Pharmaceutical UniversityChina 65.414.5%27.4×27 +82.4%
6Southern Medical UniversityChina 65.221.3%7.3×20 +13.6%
7Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 64.012.1%8.1×38 +49.7%
8University of PennsylvaniaUnited States 61.618.1%3.6×17 -13.6%
9Central South UniversityChina 59.617.6%3.3×29 -2.3%
10Peking UniversityChina 59.313.6%3.0×27 +33.3%

Universities only. The score blends citation excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Histone Deacetylase Inhibitors Research, country by country

Is Histone Deacetylase Inhibitors Research research growing?

Output in 2022-2025 was 6% higher than in 2018-2021, peaking in 2025. The fastest-growing topics are Histone Deacetylase Inhibitors Research.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Histone Deacetylase Inhibitors Research as a percentage of every work published that year, 0.022% in 2024.

still counting0.010%0.020%0.030%Histone Deacetylase Inhibitors Research0.021% in 202519801990200020102020

Fractional works of Histone Deacetylase Inhibitors Research over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Histone Deacetylase Inhibitors Research9.9% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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