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Topic · Molecular Biology

Cancer-related gene regulation

Cancer-related gene regulation is a research topic within Molecular Biology. Science Explorer counts 36k research works in it since 1950. 10.0% of them reached the world's top 10% most cited for their field and year.

This cluster of papers focuses on the role of protein arginine methylation, particularly by PRMT1 and PRMT5, in mammals. It explores its involvement in histone methylation, transcriptional regulation, epigenetic control, and its implications in cancer and cell proliferation.

  • Arginine Methylation
  • Protein Arginine Methyltransferases
  • Histone Methylation
  • PRMT5
  • Cancer
  • Transcriptional Regulation
  • PRMT1
  • Epigenetic Regulation
  • Methylation Sites
  • Cell Proliferation
Research works
36k
fractional, since 1950
In the world top 10%
3.6k
per year above
Top-10% rate
10.0%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
-1%
the tick is no change
Largest producer
China
56% of the 10 largest, 2022-now
Cancer-related gene regulation

Which countries lead Cancer-related gene regulation research?

By volume, China and the United States publish the most (3k and 1.2k works in 2022-now).

By volume, 2022-now

  1. 1 China 3k works
  2. 2 United States 1.2k works
  3. 3 Japan 218 works
  4. 4 India 196 works
  5. 5 Germany 191 works
  6. 6 United Kingdom 140 works
  7. 7 South Korea 125 works
  8. 8 France 105 works
  9. 9 Canada 104 works
  10. 10 Italy 103 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

China: 55.7%United States: 22.7%Japan: 4.0%India: 3.6%6 others listed: 14.1%56%largest
China3,045 · 55.7%United States1,238 · 22.7%Japan218 · 4.0%India196 · 3.6%6 others listed768 · 14.1%

Shares of the rows listed above, not of the whole node.

Which institutions lead Cancer-related gene regulation research?

By volume in 2022-now, Sun Yat-sen University publishes the most Cancer-related gene regulation research, followed by Shanghai Jiao Tong University and Central South University.

By volume, 2022-now

  1. 1 Sun Yat-sen UniversityChina 103 works
  2. 2 Shanghai Jiao Tong UniversityChina 77 works
  3. 3 Central South UniversityChina 75 works
  4. 4 Nanjing Medical UniversityChina 66 works
  5. 5 Zhengzhou UniversityChina 63 works
  6. 6 Zhejiang UniversityChina 62 works
  7. 7 Sichuan UniversityChina 59 works
  8. 8 Chinese Academy of SciencesChina 57 works
  9. 9 Harvard UniversityUnited States 53 works
  10. 10 Huazhong University of Science and TechnologyChina 48 works

Who are the leading researchers in Cancer-related gene regulation?

The most-cited researchers publishing on Cancer-related gene regulation include Eric S. Lander, George Davey Smith and Mark J. Daly.

  1. 1 Eric S. Lander United States 524k citations
  2. 2 George Davey Smith United Kingdom 435k citations
  3. 3 Mark J. Daly United States 403k citations
  4. 4 Stacey L. Gabriel United States 402k citations
  5. 5 Peer Bork Germany 396k citations
  6. 6 Guido Kroemer France 386k citations
  7. 7 Bert Vogelstein United States 373k citations
  8. 8 Gad A. Getz United States 364k citations
  9. 9 Elaine R. Mardis United States 346k citations
  10. 10 Hermann Brenner Germany 343k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Cancer-related gene regulation?

The most cited paper in Cancer-related gene regulation is "Translating the Histone Code" (Thomas Jenuwein, C. David Allis, 2001), with 9,803 citations. Next come "THE UBIQUITIN SYSTEM" (8,852) and "The language of covalent histone modifications" (8,728).

Most cited papers
#PaperReleasedCitations
1 Translating the Histone Code Thomas Jenuwein, C. David Allis · Science 10 Aug 2001 9,803
2 THE UBIQUITIN SYSTEM Avram Hershko, Aaron J. Ciechanover · Annual Review of Biochemistry Review Jun 1998 8,852
3 The language of covalent histone modifications Brian D. Strahl, C. David Allis · Nature 2000 8,728
4 Regulation of Ferroptotic Cancer Cell Death by GPX4 Wan Seok Yang, Rohitha Sriramaratnam, Matthew Welsch et al. · Cell Open access 2014 7,814
5 High-Resolution Profiling of Histone Methylations in the Human Genome Artem Barski, Suresh Cuddapah, Kairong Cui et al. · Cell Open access May 2007 7,037
All 100 most cited papers, with filters and sorting

Where is Cancer-related gene regulation research done?

The largest centres of Cancer-related gene regulation research in 2022-now are Beijing (China), Shanghai (China), Guangzhou (China) and Wuhan (China). Among places with at least 20 works in it, it is an unusually large share of all research in Nantong and Hengyang.

Largest cities, 2022-now

  1. 1 BeijingChina 250 works
  2. 2 ShanghaiChina 239 works
  3. 3 GuangzhouChina 230 works
  4. 4 WuhanChina 131 works
  5. 5 NanjingChina 123 works
  6. 6 HangzhouChina 118 works
  7. 7 ChangshaChina 116 works
  8. 8 JinanChina 94 works
  9. 9 ChengduChina 83 works
  10. 10 ZhengzhouChina 82 works

Where it is the local speciality

  1. NantongCN · 28.2 works9.8×
  2. HengyangCN · 20.1 works9.2×
← less than its size predicts1×more →

Location quotient: how much more of its research is in Cancer-related gene regulation than the world average.

See Cancer-related gene regulation on the map

Where is the best place to study Cancer-related gene regulation?

Among universities, judged by research, Sun Yat-sen University, Harvard University and Huazhong University of Science and Technology score highest, combining citation excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%10%20%mean 16.47%fractional works in this field (log) →share of work in the world top 10% →Sun Yat-sen UniversityHuazhong University …Harvard UniversityCentral South Univer…
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Citation excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Sun Yat-sen UniversityChina 89.922.7%9.2×103 +13.8%
2Harvard UniversityUnited States 76.815.4%3.1×53 +3.6%
3Huazhong University of Science and TechnologyChina 71.020.0%4.9×48 +32.6%
4Central South UniversityChina 67.814.1%7.2×75 +43.5%
5Sichuan UniversityChina 66.714.7%4.8×59 +44.3%
6Zhejiang UniversityChina 66.515.0%4.3×62 +1.2%
7Nanjing Medical UniversityChina 66.415.6%13.8×66 -2.8%
8Peking UniversityChina 65.218.1%3.7×41 +4.8%
9Guangzhou Medical UniversityChina 64.316.2%16.3×32 +54.4%
10Shanghai Jiao Tong UniversityChina 63.612.9%4.9×77 +5.6%

Universities only. The score blends citation excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Cancer-related gene regulation, country by country

Is Cancer-related gene regulation research growing?

Output in 2022-2025 was 1% lower than in 2018-2021, peaking in 2022.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Cancer-related gene regulation as a percentage of every work published that year, 0.026% in 2024.

still counting0.020%0.040%0.060%Cancer-related gene regulation0.023% in 202519801990200020102020

Fractional works of Cancer-related gene regulation over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Cancer-related gene regulation10.1% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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