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Topic · Molecular Biology

Chromatin Remodeling and Cancer

Chromatin Remodeling and Cancer is a research topic within Molecular Biology. Science Explorer counts 8.8k research works in it since 1952. 10.3% of them reached the world's top 10% most cited for their field and year.

This cluster of papers focuses on the role of chromatin remodeling, particularly the SWI/SNF complexes and ARID1A mutations, in cancer development and progression. It explores the impact of these mutations on epigenetic regulation, tumor suppression, genomic analysis, oncogenic transformation, and synthetic lethality. Additionally, it delves into the involvement of chromatin remodeling in mammalian development.

  • Chromatin Remodeling
  • SWI/SNF Complexes
  • ARID1A Mutations
  • Cancer
  • Epigenetics
  • Tumor Suppressor
  • Genomic Analysis
  • Oncogenic Transformation
  • Synthetic Lethality
  • Mammalian Development
Research works
8.8k
fractional, since 1952
In the world top 10%
903
per year above
Top-10% rate
10.3%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
+27%
the tick is no change
Largest producer
United States
36% of the 10 largest, 2022-now
Chromatin Remodeling and Cancer

Which countries lead Chromatin Remodeling and Cancer research?

By volume, the United States and China publish the most (819 and 760 works in 2022-now).

By volume, 2022-now

  1. 1 United States 819 works
  2. 2 China 760 works
  3. 3 Japan 132 works
  4. 4 Germany 124 works
  5. 5 India 102 works
  6. 6 United Kingdom 87 works
  7. 7 Italy 78 works
  8. 8 Canada 74 works
  9. 9 France 66 works
  10. 10 Spain 43 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

United States: 35.8%China: 33.3%Japan: 5.8%Germany: 5.4%6 others listed: 19.7%36%largest
United States819 · 35.8%China760 · 33.3%Japan132 · 5.8%Germany124 · 5.4%6 others listed450 · 19.7%

Shares of the rows listed above, not of the whole node.

Which institutions lead Chromatin Remodeling and Cancer research?

By volume in 2022-now, Harvard University publishes the most Chromatin Remodeling and Cancer research, followed by The University of Texas MD Anderson Cancer Center and National Institutes of Health.

By volume, 2022-now

  1. 1 Harvard UniversityUnited States 45 works
  2. 2 The University of Texas MD Anderson Cancer CenterUnited States 30 works
  3. 3 National Institutes of HealthUnited States 26 works
  4. 4 Shanghai Jiao Tong UniversityChina 26 works
  5. 5 Johns Hopkins UniversityUnited States 24 works
  6. 6 Sun Yat-sen UniversityChina 21 works
  7. 7 Nanjing Medical UniversityChina 21 works
  8. 8 Sichuan UniversityChina 20 works
  9. 9 University of North Carolina at Chapel HillUnited States 18 works
  10. 10 Zhejiang UniversityChina 17 works

Who are the leading researchers in Chromatin Remodeling and Cancer?

The most-cited researchers publishing on Chromatin Remodeling and Cancer include Stacey L. Gabriel, Bert Vogelstein and Gad A. Getz.

  1. 1 Stacey L. Gabriel United States 402k citations
  2. 2 Bert Vogelstein United States 373k citations
  3. 3 Gad A. Getz United States 364k citations
  4. 4 Elaine R. Mardis United States 346k citations
  5. 5 Jun Wang China 340k citations
  6. 6 Richard A. Gibbs United States 292k citations
  7. 7 Todd R. Golub United States 283k citations
  8. 8 Matthew M. Meyerson United States 280k citations
  9. 9 Chris Sander United States 276k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Chromatin Remodeling and Cancer?

The most cited paper in Chromatin Remodeling and Cancer is "The 2007 WHO Classification of Tumours of the Central Nervous System" (Hiroko Ohgaki, Otmar Dieter Wiestler, Webster K. Cavenee et al., 2007), with 14,012 citations. Next come "Integrated genomic characterization of endometrial carcinoma" (5,963) and "Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia" (5,244).

Most cited papers
#PaperReleasedCitations
1 The 2007 WHO Classification of Tumours of the Central Nervous System Hiroko Ohgaki, Otmar Dieter Wiestler, Webster K. Cavenee et al. · Digital Access to Scholarship at Harvard (DASH) (Harvard University) Open access 2007 14,012
2 Integrated genomic characterization of endometrial carcinoma Douglas A. Levine · Nature Open access 30 Apr 2013 5,963
3 Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia The Cancer Genome Atlas Research Network · New England Journal of Medicine Open access 2 May 2013 5,244
4 Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma Jeremy Schwartzentruber et al. · Nature 27 Jan 2012 2,736
5 SMARCAD1 ATPase activity is required to silence endogenous retroviruses in embryonic stem cells Parysatis Sachs, Dong Ding, Philipp Bergmaier et al. · Nature Communications Open access 22 Mar 2019 2,423
All 100 most cited papers, with filters and sorting

Where is Chromatin Remodeling and Cancer research done?

The largest centres of Chromatin Remodeling and Cancer research in 2022-now are Shanghai (China), Beijing (China), Guangzhou (China) and Houston (United States). Among places with at least 20 works in it, it is an unusually large share of all research in Heidelberg, Bethesda and Houston.

Largest cities, 2022-now

  1. 1 ShanghaiChina 83 works
  2. 2 BeijingChina 79 works
  3. 3 GuangzhouChina 54 works
  4. 4 HoustonUnited States 48 works
  5. 5 New YorkUnited States 39 works
  6. 6 NanjingChina 36 works
  7. 7 BostonUnited States 35 works
  8. 8 HangzhouChina 34 works
  9. 9 LondonUnited Kingdom 34 works
  10. 10 BaltimoreUnited States 33 works

Where it is the local speciality

  1. HeidelbergDE · 21.0 works7.8×
  2. BethesdaUS · 24.2 works7.6×
  3. HoustonUS · 47.9 works7.4×
  4. BaltimoreUS · 33.5 works5.3×
← less than its size predicts1×more →

Location quotient: how much more of its research is in Chromatin Remodeling and Cancer than the world average.

See Chromatin Remodeling and Cancer on the map

Where is the best place to study Chromatin Remodeling and Cancer?

Among universities, judged by research, Harvard University, Stanford University and Johns Hopkins University score highest, combining citation excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%10%20%mean 17.12%fractional works in this field (log) →share of work in the world top 10% →Harvard UniversityStanford UniversitySun Yat-sen UniversityJohns Hopkins Univer…
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Citation excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Harvard UniversityUnited States 86.220.9%6.0×45 -11.6%
2Stanford UniversityUnited States 63.219.4%3.4×12 +25.3%
3Johns Hopkins UniversityUnited States 59.911.7%6.8×24 +8.7%
4Sun Yat-sen UniversityChina 53.215.1%4.4×21 +35.5%
5University of PennsylvaniaUnited States 52.919.0%4.1×10 +34.6%
6Heidelberg UniversityGermany 52.314.5%7.6×14 -19.6%
7Cornell UniversityUnited States 49.620.3%3.2×10 +34.1%
8Fudan UniversityChina 48.713.7%4.5×17 +26.3%
9Northwestern UniversityUnited States 47.620.8%5.0×10 -5.7%
10University of MichiganUnited States 47.115.8%3.5×12 +25.9%

Universities only. The score blends citation excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Chromatin Remodeling and Cancer, country by country

Is Chromatin Remodeling and Cancer research growing?

Output in 2022-2025 was 27% higher than in 2018-2021, peaking in 2025. The fastest-growing topics are Chromatin Remodeling and Cancer.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Chromatin Remodeling and Cancer as a percentage of every work published that year, 0.0093% in 2024.

still counting0.0050%0.010%0.015%Chromatin Remodeling and Cancer0.011% in 202519801990200020102020

Fractional works of Chromatin Remodeling and Cancer over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Chromatin Remodeling and Cancer10.2% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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