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Topic · Materials Chemistry

Enzyme Structure and Function

Enzyme Structure and Function is a research topic within Materials Chemistry. Science Explorer counts 54k research works in it since 1950. 9.8% of them reached the world's top 10% most cited for their field and year.

This cluster of papers encompasses advancements in macromolecular crystallography techniques, including automated model building, small-angle scattering for structural analysis, protein stability assessment, and high-throughput crystallization methods. It also covers topics such as enzyme structure determination, X-ray solution scattering, and data processing for structure solution.

  • Macromolecular Crystallography
  • Structure Solution
  • Small-Angle Scattering
  • Automated Model Building
  • Crystal Structure Determination
  • Protein Stability
  • X-ray Solution Scattering
  • Data Processing
  • Enzyme Structure
  • High-Throughput Crystallization
Research works
54k
fractional, since 1950
In the world top 10%
5.3k
per year above
Top-10% rate
9.8%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
-12%
the tick is no change
Largest producer
United States
33% of the 10 largest, 2022-now
Enzyme Structure and Function

Which countries lead Enzyme Structure and Function research?

By volume, the United States and China publish the most (1.2k and 683 works in 2022-now).

By volume, 2022-now

  1. 1 United States 1.2k works
  2. 2 China 683 works
  3. 3 Germany 333 works
  4. 4 Japan 293 works
  5. 5 India 284 works
  6. 6 United Kingdom 233 works
  7. 7 France 189 works
  8. 8 Russia 159 works
  9. 9 Italy 111 works
  10. 10 South Korea 106 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

United States: 32.7%China: 19.2%Germany: 9.4%Japan: 8.3%6 others listed: 30.5%33%largest
United States1,161 · 32.7%China683 · 19.2%Germany333 · 9.4%Japan293 · 8.3%6 others listed1,081 · 30.5%

Shares of the rows listed above, not of the whole node.

Which institutions lead Enzyme Structure and Function research?

By volume in 2022-now, Centre National de la Recherche Scientifique publishes the most Enzyme Structure and Function research, followed by Russian Academy of Sciences and Chinese Academy of Sciences.

By volume, 2022-now

  1. 1 Centre National de la Recherche ScientifiqueFrance 88 works
  2. 2 Russian Academy of SciencesRussia 83 works
  3. 3 Chinese Academy of SciencesChina 74 works
  4. 4 Jiangnan UniversityChina 37 works
  5. 5 Max Planck SocietyGermany 34 works
  6. 6 Helmholtz Association of German Research CentresGermany 34 works
  7. 7 National Institutes of HealthUnited States 31 works
  8. 8 Stanford UniversityUnited States 24 works
  9. 9 Consejo Superior de Investigaciones CientíficasSpain 22 works
  10. 10 RIKENJapan 21 works

Who are the leading researchers in Enzyme Structure and Function?

The most-cited researchers publishing on Enzyme Structure and Function include Rob Knight, George Davey Smith and Peer Bork.

  1. 1 Rob Knight United States 468k citations
  2. 2 George Davey Smith United Kingdom 435k citations
  3. 3 Peer Bork Germany 396k citations
  4. 4 Jun Wang China 340k citations
  5. 5 Matthias Mann Germany 308k citations
  6. 6 Trevor Hastie United States 301k citations
  7. 7 Robert A. Weinberg United States 301k citations
  8. 8 Richard A. Gibbs United States 292k citations
  9. 9 Ulrich K. Laemmli Switzerland 285k citations
  10. 10 Chris Sander United States 276k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Enzyme Structure and Function?

The most cited paper in Enzyme Structure and Function is "A short history of SHELX" (George M. Sheldrick, 2007), with 87,903 citations. Next come "VMD: Visual molecular dynamics" (68,537) and "Highly accurate protein structure prediction with AlphaFold" (47,486).

Most cited papers
#PaperReleasedCitations
1 A short history of SHELX George M. Sheldrick · Acta Crystallographica Section A Foundations of Crystallography Open access 21 Dec 2007 87,903
2 VMD: Visual molecular dynamics William F Humphrey Jr, Andrew Dalke, Klaus J. Schulten · Journal of Molecular Graphics Feb 1996 68,537
3 Highly accurate protein structure prediction with AlphaFold John Jumper et al. · Nature Open access 15 Jul 2021 47,486
4 Crystal structure refinement with SHELXL George M. Sheldrick · Acta Crystallographica Section C Structural Chemistry Open access 30 Dec 2014 43,688
5 The Protein Data Bank Helen Miriam Berman · Nucleic Acids Research Open access 2000 40,564
All 100 most cited papers, with filters and sorting

Where is Enzyme Structure and Function research done?

The largest centres of Enzyme Structure and Function research in 2022-now are Beijing (China), Moscow (Russia), Paris (France) and Tokyo (Japan). Among places with at least 20 works in it, it is an unusually large share of all research in Grenoble.

Largest cities, 2022-now

  1. 1 BeijingChina 119 works
  2. 2 MoscowRussia 97 works
  3. 3 ParisFrance 82 works
  4. 4 TokyoJapan 67 works
  5. 5 ShanghaiChina 64 works
  6. 6 HangzhouChina 50 works
  7. 7 LondonUnited Kingdom 49 works
  8. 8 WuxiChina 45 works
  9. 9 HamburgGermany 43 works
  10. 10 SeoulSouth Korea 43 works

Where it is the local speciality

  1. GrenobleFR · 29.7 works14×
← less than its size predicts1×more →

Location quotient: how much more of its research is in Enzyme Structure and Function than the world average.

See Enzyme Structure and Function on the map

Where is the best place to study Enzyme Structure and Function?

Among universities, judged by research, Jiangnan University, University of Toronto and Stanford University score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%20%40%mean 18.26%fractional works in this field (log) →share of work in the world top 10% →University of TorontoZhejiang University …Jiangnan UniversityStanford University
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Jiangnan UniversityChina 66.016.5%16.1×37 +5.1%
2University of TorontoCanada 58.419.6%2.1×17 +7.0%
3Stanford UniversityUnited States 58.012.3%4.2×24 -12.5%
4Zhejiang University of TechnologyChina 56.917.1%9.1×20 +88.1%
5Universität HamburgGermany 56.414.3%6.8×20 +8.4%
6University College LondonUnited Kingdom 55.120.8%2.2×14 -7.4%
7Harvard UniversityUnited States 54.419.4%1.2×16 -5.7%
8University of CopenhagenDenmark 54.112.7%4.6×17 +20.5%
9University of California, San FranciscoUnited States 53.030.2%3.5×10 -20.5%
10ETH ZurichSwitzerland 52.919.7%4.5×12 -25.9%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Enzyme Structure and Function, country by country

Is Enzyme Structure and Function research growing?

Output in 2022-2025 was 12% lower than in 2018-2021, peaking in 2014.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Enzyme Structure and Function as a percentage of every work published that year, 0.018% in 2024.

still counting0.050%0.10%0.15%Enzyme Structure and Function0.017% in 202519801990200020102020

Fractional works of Enzyme Structure and Function over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Enzyme Structure and Function9.9% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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