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Nonprofit · Des Moines · United States

Human Gene Therapy Research Institute

hgtri.orgROR OpenAlex
World rank, all time
#33,834
of 34,923
Rank in United States
#7,105
of 7,310
Research works
134
▼ 13% vs 2018-21
Citations
10k
76.2 per fractional work
Top-10% rate
7.1%
all institutions 10.0%
vs its own fields
1.16×
1.00× is exactly expected
Open access
26%
world 40%
International
13%
world 18%
Human Gene Therapy Research Institute

Which fields of science does Human Gene Therapy Research Institute work in?

In all years, 59% of research at Human Gene Therapy Research Institute is in Life Sciences, 32% in Health Sciences. Its largest fields are Biochemistry, Genetics and Molecular Biology (51%), Medicine (30%), Immunology and Microbiology (7%). It does 3.5× the world's share of Life Sciences.

Life Sciences: 79 fractional works · 58.7% of its workBiochemistry, Genetics and Molecular Biology: 68 fractional works · 50.6% of its workMolecular Biology: 31 fractional works · 23.0% of its workGenetics: 27 fractional works · 20.4% of its workBiotechnology: 4 fractional works · 3.2% of its workCancer Research: 2 fractional works · 1.1% of its workCell Biology: 1 fractional works · 0.9% of its workBiophysics: 1 fractional works · 0.5% of its workClinical Biochemistry: 1 fractional works · 0.5% of its workBiochemistry: 1 fractional works · 0.4% of its workEndocrinology: 0 fractional works · 0.4% of its workPhysiology: 0 fractional works · 0.2% of its workImmunology and Microbiology: 10 fractional works · 7.4% of its workImmunology: 9 fractional works · 6.9% of its workVirology: 0 fractional works · 0.4% of its workSmaller subfields together: 0 fractional works · 0.2% of its workAgricultural and Biological Sciences: 1 fractional works · 0.5% of its workPlant Science: 0 fractional works · 0.3% of its workSmaller subfields together: 0 fractional works · 0.2% of its workPharmacology, Toxicology and Pharmaceutics: 0 fractional works · 0.1% of its workNeuroscience: 0 fractional works · 0.1% of its workHealth Sciences: 43 fractional works · 32.3% of its workMedicine: 41 fractional works · 30.3% of its workOncology: 8 fractional works · 5.9% of its workInfectious Diseases: 5 fractional works · 3.4% of its workPulmonary and Respiratory Medicine: 4 fractional works · 3.2% of its workSurgery: 4 fractional works · 2.8% of its workEpidemiology: 3 fractional works · 2.4% of its workHematology: 3 fractional works · 1.9% of its workPhysiology: 2 fractional works · 1.5% of its workCardiology and Cardiovascular Medicine: 1 fractional works · 1.1% of its workRadiology, Nuclear Medicine and Imaging: 1 fractional works · 1.0% of its workImmunology and Allergy: 1 fractional works · 0.9% of its workNephrology: 1 fractional works · 0.6% of its workPathology and Forensic Medicine: 1 fractional works · 0.6% of its workReproductive Medicine: 1 fractional works · 0.6% of its workDermatology: 1 fractional works · 0.5% of its workGenetics: 1 fractional works · 0.5% of its workNeurology: 1 fractional works · 0.5% of its workPublic Health, Environmental and Occupational Health: 1 fractional works · 0.5% of its workPediatrics, Perinatology and Child Health: 1 fractional works · 0.4% of its workHepatology: 0 fractional works · 0.4% of its workPharmacology: 0 fractional works · 0.4% of its workRheumatology: 0 fractional works · 0.4% of its workOrthopedics and Sports Medicine: 0 fractional works · 0.3% of its workSmaller subfields together: 1 fractional works · 0.5% of its workHealth Professions: 2 fractional works · 1.4% of its workGeneral Health Professions: 1 fractional works · 1.0% of its workSmaller subfields together: 1 fractional works · 0.4% of its workDentistry: 1 fractional works · 0.5% of its workPeriodontics: 1 fractional works · 0.5% of its workNursing: 0 fractional works · 0.2% of its workSocial Sciences: 9 fractional works · 6.8% of its workSocial Sciences: 5 fractional works · 3.7% of its workSociology and Political Science: 2 fractional works · 1.2% of its workGender Studies: 1 fractional works · 1.0% of its workPolitical Science and International Relations: 1 fractional works · 0.7% of its workDemography: 1 fractional works · 0.4% of its workEducation: 0 fractional works · 0.2% of its workSmaller subfields together: 0 fractional works · 0.1% of its workPsychology: 3 fractional works · 2.0% of its workClinical Psychology: 2 fractional works · 1.6% of its workSocial Psychology: 0 fractional works · 0.4% of its workArts and Humanities: 1 fractional works · 0.7% of its workPhilosophy: 1 fractional works · 0.5% of its workLanguage and Linguistics: 0 fractional works · 0.2% of its workBusiness, Management and Accounting: 0 fractional works · 0.2% of its workDecision Sciences: 0 fractional works · 0.2% of its workPhysical Sciences: 3 fractional works · 2.1% of its workEnvironmental Science: 2 fractional works · 1.3% of its workEcology: 2 fractional works · 1.2% of its workSmaller subfields together: 0 fractional works · 0.0% of its workEngineering: 1 fractional works · 0.8% of its workElectrical and Electronic Engineering: 1 fractional works · 0.4% of its workMechanics of Materials: 0 fractional works · 0.2% of its workSmaller subfields together: 0 fractional works · 0.1% of its workPhysics and Astronomy: 0 fractional works · 0.1% of its workALL ITS WORKHuman GeneTherapy Research…134fractional works, all years
Life Sciences59%Physical Sciences2%Health Sciences32%Social Sciences7%

Each ring splits the one inside it: the four domains of science, their fields, their subfields. Size is fractional works in all years. Every slice is a page; the interactive view zooms down to single topics and colours each by how much more of it this institution does than the world.

Its 4 domains and 18 fields, with their numbers
    1. Biochemistry, Genetics and Molecular Biology6850.6%
    2. Immunology and Microbiology107.4%
    3. Agricultural and Biological Sciences10.5%
    4. Pharmacology, Toxicology and Pharmaceutics00.1%
    5. Neuroscience00.1%
    1. Medicine4130.3%
    2. Health Professions21.4%
    3. Dentistry10.5%
    4. Nursing00.2%
    1. Social Sciences53.7%
    2. Psychology32.0%
    3. Arts and Humanities10.7%
    4. Business, Management and Accounting00.2%
    5. Decision Sciences00.2%
    1. Environmental Science21.3%
    2. Engineering10.8%
    3. Physics and Astronomy00.1%
    4. Mathematics00.0%
All of science, and how each field's share has moved since 1950: the Science domain explorer

Field profile

Location quotient across every field it publishes in: outside the ring is more than an institution of this size would be expected to publish, inside it is less.

Biochemistry, Genetics and Molecular Biology: 4.89× its world share, 1 worksBiochemistry, Geneti…Immunology and Microbiology: 6.84× its world share, 0 worksImmunology and Micro…Engineering: 0.33× its world share, 0 worksEngineeringEnvironmental Science: 0.28× its world share, 0 worksEnvironmental ScienceMathematics: 0.60× its world share, 0 worksMathematicsHealth Professions: 1.86× its world share, 0 worksHealth ProfessionsMedicine: 2.61× its world share, 2 worksMedicineSocial Sciences: 0.39× its world share, 0 worksSocial Sciences1×world share
more than its size predictsabout as predictedless

Rings at 0.5×, 1× and 2×. Widest outward: Immunology and Microbiology, 6.8×. Every wedge is a field page.

All 8 fields, with their numbers
  1. Immunology and Microbiology6.84×0 works
  2. Biochemistry, Genetics and Molecular Biology4.89×1 works
  3. Medicine2.61×2 works
  4. Health Professions1.86×0 works
  5. Mathematics0.60×0 works
  6. Social Sciences0.39×0 works
  7. Engineering0.33×0 works
  8. Environmental Science0.28×0 works

Who are the top researchers at Human Gene Therapy Research Institute?

Ranked on the quality score, Lois Braverman, John P. Levy and Tatiana Seregina lead among researchers whose main affiliation is Human Gene Therapy Research Institute.

  1. 1 Lois Braverman United States · #4,323,100 worldwide 115 citations · 19 works
  2. 2 John P. Levy United States · #4,898,622 worldwide 513 citations · 34 works
  3. 3 Tatiana Seregina United States · #4,951,947 worldwide 412 citations · 23 works
All ranked researchers at Human Gene Therapy Research Institute

What are the most cited papers from Human Gene Therapy Research Institute?

The most cited paper from Human Gene Therapy Research Institute is "Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses" (Ya‐Wen Yang, Qunyang Li, Hildegund C.J. Ertl et al., 1995), with 1,036 citations. Next come "Engineering targeted viral vectors for gene therapy" (689) and "Immune responses to adenovirus and adeno-associated virus in humans" (684).

Most cited papers
#PaperReleasedCitations
1 Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses Ya‐Wen Yang, Qunyang Li, Hildegund C.J. Ertl et al. · Journal of Virology Open access Apr 1995 1,036
2 Engineering targeted viral vectors for gene therapy Reinhard Waehler, Stephen J. Russell, David T. Curiel · Nature Reviews Genetics ReviewOpen access 3 Jul 2007 689
3 Immune responses to adenovirus and adeno-associated virus in humans Narendra B. Chirmule, KATHLEEN JOY PROPERT, Susan Magosin et al. · Gene Therapy Sep 1999 684
4 Recombinant adeno-associated virus for muscle directed gene therapy Krishna J. Fisher, Karin U. Jooss, J. M. Alston et al. · Nature Medicine Mar 1997 659
5 Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver. John F. Engelhardt, Xiaoyang Ye, B Doranz et al. · Proceedings of the National Academy of Sciences Open access 21 Jun 1994 626
All 60 most cited papers, with filters and sorting

Which keywords describe research at Human Gene Therapy Research Institute?

By fractional works in all years, weighted toward what it does more of than the world: Gene Therapy, Genomic Integration, AAV, Viral Vectors, Immunotherapy, Tumor Regression, Biopharmaceutical Production and Cancer Immunotherapy.

▲ more of its work than of the world's◆ about the world's share▼ less than the world's

Size is fractional works in all years in the topics tagged with each word; colour is the word's share of this institution's work against its share of the world's. The 40 words are chosen for being large and distinctive. Each links to the topic it comes from most.

All 40 words, with their numbers
  1. Gene Therapy34▲ 96×5 topics
  2. Genomic Integration25▲ 182×2 topics
  3. AAV23▲ 260×1 topic
  4. Viral Vectors23▲ 260×1 topic
  5. Immunotherapy12▲ 14×9 topics
  6. Epidemiology12▲ 2.2×21 topics
  7. Tumor Regression10▲ 86×2 topics
  8. Biopharmaceutical Production9▲ 88×2 topics
  9. Cancer Immunotherapy8▲ 44×2 topics
  10. Genome Engineering8▲ 102×1 topic
  11. RNA-Guided8▲ 102×1 topic
  12. Glycosylation8▲ 26×3 topics
  13. Vaccine7▲ 13×5 topics
  14. Lymphoma7▲ 33×4 topics
  15. Mammalian Cells6▲ 124×1 topic
  16. Recombinant Protein6▲ 124×1 topic
  17. Gene Silencing6▲ 39×2 topics
  18. Inflammation6▲ 1.97×22 topics
  19. Leukemia6▲ 69×2 topics
  20. RNA Interference6▲ 40×1 topic
  21. siRNA Delivery6▲ 60×1 topic
  22. CAR T Cells6▲ 100×1 topic
  23. Chimeric Antigen Receptor6▲ 100×1 topic
  24. Cancer5▲ 2.9×14 topics
  25. Infection5▲ 13×3 topics
  26. Pathogenesis5▲ 6.4×6 topics
  27. Norovirus4▲ 55×1 topic
  28. Rotavirus4▲ 55×1 topic
  29. Bacterial Therapy4▲ 72×1 topic
  30. Tumor Targeting4▲ 24×1 topic
  31. Immunity4▲ 9.0×4 topics
  32. Immune Response4▲ 4.8×6 topics
  33. Embryonic Stem Cells3▲ 32×2 topics
  34. Gene Expression3▲ 4.0×3 topics
  35. Innate Immunity3▲ 6.8×4 topics
  36. Autoimmunity3▲ 11×3 topics
  37. Genetic Modification3▲ 53×1 topic
  38. Transgenic Animals3▲ 53×1 topic
  39. Antigen Presentation2▲ 18×1 topic
  40. Dendritic Cells2▲ 15×1 topic

Which research topics does Human Gene Therapy Research Institute publish most on?

By volume in 2022-now: Pluripotent Stem Cells Research, Biomedical Ethics and Regulation, Genital Health and Disease and Medicine and Dermatology Studies History.

Pluripotent Stem Cells R…0Pluripotent Stem Cells Research: 0 fractional worksBiomedical Ethics and Re…0Biomedical Ethics and Regulation: 0 fractional worksGenital Health and Disease: 0 fractional worksMedicine and Dermatology Studies History: 0 fractional worksT-cell and Retrovirus St…0T-cell and Retrovirus Studies: 0 fractional worksEmpathy and Medical Education: 0 fractional worksCRISPR and Genetic Engineering: 0 fractional worksVirus-based gene therapy…0Virus-based gene therapy research: 0 fractional worksVaccine Coverage and Hesitancy: 0 fractional worksHealthcare Systems and Challenges: 0 fractional works
Molecular BiologyPhysiologySurgeryDermatology5 others

Area is fractional works; colour is the subfield each topic belongs to.

  1. 1 Pluripotent Stem Cells Research Molecular Biology 0 works
  2. 2 Biomedical Ethics and Regulation Physiology 0 works
  3. 3 Genital Health and Disease Surgery 0 works
  4. 4 Medicine and Dermatology Studies History Dermatology 0 works
  5. 5 T-cell and Retrovirus Studies Immunology 0 works
  6. 6 Empathy and Medical Education Psychiatry and Mental health 0 works
  7. 7 CRISPR and Genetic Engineering Molecular Biology 0 works
  8. 8 Virus-based gene therapy research Genetics 0 works
  9. 9 Vaccine Coverage and Hesitancy Health 0 works
  10. 10 Healthcare Systems and Challenges General Health Professions 0 works

How open and international is its research?

Against the world's own shares: the tick on each track. Both are shares of its output, so they sit on one scale and can be read against each other as well as against the world.

openly available26.3%not open73.7%

World: 40% of research is openly available.

with international co-authors13.4%domestic only86.6%

World: 18% is written across borders.

How has Human Gene Therapy Research Institute's research output changed?

Output in 2022-2025 was 13% lower than in 2018-2021.

still counting1990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Human Gene Therapy Research Institute as a percentage of every work published that year, 0.0000090% in 2024.

still counting0.00050%0.0010%0.0015%Human Gene Therapy Research Institute0.000018% in 20251990200020102020

Fractional works of Human Gene Therapy Research Institute over all fractional works that year. How the balance of science has shifted.

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Human Gene Therapy Research Institute on Science Explorer

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