CRISPR and Genetic Engineering

CRISPR and Genetic Engineering is a research topic within Molecular Biology. Science Explorer counts 65k research works in it since 1950. 9.8% of them reached the world's top 10% most cited for their field and year.

This cluster of papers focuses on the use of CRISPR-Cas systems for genome engineering, RNA-guided gene editing, and bacterial immunity. It covers topics such as Cas9 nucleases, off-target effects, multiplex genome editing, and genetic screening using CRISPR technology.

Genome Engineering
RNA-Guided
Cas9
Nucleases
Gene Editing
CRISPR Systems
Multiplex Genome Editing
Off-Target Effects
Bacterial Immunity
Genetic Screening

Research works: 65k
In the world top 10%: 6.3k
Top-10% rate: 9.8%
Growth, 2018-21 → 2022-25: +14%
Largest producer: United States

CRISPR and Genetic Engineering

Which countries lead CRISPR and Genetic Engineering research?

By volume, the United States and China publish the most (3.9k and 3.7k works in 2022-now).

By volume, 2022-now

1 United States 3.9k works
2 China 3.7k works
3 India 976 works
4 Germany 601 works
5 United Kingdom 592 works
6 Japan 574 works
7 South Korea 393 works
8 France 368 works
9 Canada 336 works
10 Russia 296 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

United States3,930 · 33.3%China3,722 · 31.6%India976 · 8.3%Germany601 · 5.1%6 others listed2,559 · 21.7%

Shares of the rows listed above, not of the whole node.

Which institutions lead CRISPR and Genetic Engineering research?

By volume in 2022-now, Chinese Academy of Sciences publishes the most CRISPR and Genetic Engineering research, followed by Chinese Academy of Agricultural Sciences and Harvard University.

By volume, 2022-now

1 Chinese Academy of SciencesChina 230 works
2 Chinese Academy of Agricultural SciencesChina 196 works
3 Harvard UniversityUnited States 190 works
4 Russian Academy of SciencesRussia 139 works
5 National Institutes of HealthUnited States 110 works
6 Indian Council of Agricultural ResearchIndia 108 works
7 Centre National de la Recherche ScientifiqueFrance 98 works
8 Zhejiang UniversityChina 82 works
9 Stanford UniversityUnited States 78 works
10 Peking UniversityChina 75 works

Who are the leading researchers in CRISPR and Genetic Engineering?

The most-cited researchers publishing on CRISPR and Genetic Engineering include Eric S. Lander, Rob Knight and Richard M. Durbin.

1 Eric S. Lander United States 524k citations
2 Rob Knight United States 468k citations
3 Richard M. Durbin United Kingdom 410k citations
4 Mark J. Daly United States 403k citations
5 Stacey L. Gabriel United States 402k citations
6 Peer Bork Germany 396k citations
7 Guido Kroemer France 386k citations
8 Bert Vogelstein United States 373k citations
9 Steven L. Salzberg United States 372k citations
10 Gad A. Getz United States 364k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in CRISPR and Genetic Engineering?

The most cited paper in CRISPR and Genetic Engineering is "Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors" (Kazutoshi Takahashi, Shinya Yamanaka, 2006), with 26,957 citations. Next come "A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity" (17,763) and "Multiplex Genome Engineering Using CRISPR/Cas Systems" (16,026).

Most cited papers
#	Paper	Released	Citations
1	Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors Kazutoshi Takahashi, Shinya Yamanaka · Cell Open access	Aug 2006	26,957
2	A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity Martin Jínek, Krzysztof Chylinski, Ines Fonfara et al. · Science Open access	29 Jun 2012	17,763
3	Multiplex Genome Engineering Using CRISPR/Cas Systems Le Dinh Công, F. Ann Ran, David B. T. Cox et al. · Science Open access	4 Jan 2013	16,026
4	Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans Andrew Z. Fire, Siqun Xu, Mary Katherine Montgomery et al. · Nature Open access	Feb 1998	15,508
5	One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products Kirill A. Datsenko, Barry L. Wanner · Proceedings of the National Academy of Sciences Open access	30 May 2000	15,367

All 100 most cited papers, with filters and sorting

Where is CRISPR and Genetic Engineering research done?

The largest centres of CRISPR and Genetic Engineering research in 2022-now are Beijing (China), Shanghai (China), Guangzhou (China) and Wuhan (China). Among places with at least 20 works in it, it is an unusually large share of all research in Chevy Chase.

Largest cities, 2022-now

1 BeijingChina 723 works
2 ShanghaiChina 315 works
3 GuangzhouChina 236 works
4 WuhanChina 199 works
5 CambridgeUnited States 190 works
6 New YorkUnited States 186 works
7 LondonUnited Kingdom 183 works
8 HangzhouChina 182 works
9 TokyoJapan 178 works
10 ParisFrance 178 works

Where it is the local speciality

Chevy ChaseUS · 36.3 works27×

← less than its size predicts1×more →

Location quotient: how much more of its research is in CRISPR and Genetic Engineering than the world average.

See CRISPR and Genetic Engineering on the map

Where is the best place to study CRISPR and Genetic Engineering?

Among universities, judged by research, Harvard University, Massachusetts Institute of Technology and Tianjin University of Science and Technology score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged

40%

Specialisationhow much of its work is in this field, counted up to 10× the world share

10%

Sizeits output in this field, on a log scale

30%

Growthoutput growth, counted from -20% to +20%

10%

Internationalshare of its work with a co-author abroad

10%

Each slider sets a weight; the share it gets of the score is beside it.

#	University	Score	Top 10%	Specialisation	Works	Growth
1	Harvard UniversityUnited States	73.9	18.7%	4.6×	190	-13.3%
2	Massachusetts Institute of TechnologyUnited States	66.4	20.7%	5.5×	50	-15.5%
3	Tianjin University of Science and TechnologyChina	66.1	29.9%	6.7×	16	+126.0%
4	Peking UniversityChina	61.7	15.9%	2.8×	75	+31.6%
5	Huazhong Agricultural UniversityChina	60.7	15.9%	11.3×	49	+30.2%
6	Zhejiang UniversityChina	60.2	15.4%	2.4×	82	+52.9%
7	King Abdullah University of Science and TechnologySaudi Arabia	60.0	13.9%	4.3×	15	+22.7%
8	Stanford UniversityUnited States	57.8	15.8%	4.1×	78	-15.4%
9	Sichuan UniversityChina	57.7	19.0%	1.9×	56	+57.3%
10	University of Chinese Academy of SciencesChina	56.6	16.4%	2.5×	53	+9.2%
11	Hubei UniversityChina	56.3	19.6%	7.4×	18	+166.1%
12	University of California, BerkeleyUnited States	56.2	15.1%	4.3×	53	-6.4%
13	China Agricultural UniversityChina	55.3	14.1%	6.3×	45	+89.8%
14	University of CambridgeUnited Kingdom	55.0	20.4%	2.4×	38	-21.6%
15	Shanghai Jiao Tong UniversityChina	54.8	14.9%	1.9×	71	+51.6%
16	Wuhan UniversityChina	54.1	17.2%	2.3×	43	+81.8%
17	Jiangnan UniversityChina	53.6	17.6%	4.0×	31	+57.2%
18	Cornell UniversityUnited States	53.5	12.6%	3.7×	62	-1.5%
19	Rice UniversityUnited States	53.5	18.1%	6.8×	19	+59.2%
20	Westlake UniversityChina	52.9	16.9%	9.1×	15	+270.7%
21	University of California San DiegoUnited States	52.6	13.6%	4.4×	56	-5.9%
22	University of Massachusetts Chan Medical SchoolUnited States	52.3	15.6%	14.2×	31	-10.9%
23	Zhengzhou UniversityChina	52.0	17.6%	2.2×	35	+103.6%
24	University of PennsylvaniaUnited States	51.5	14.8%	3.8×	52	-7.3%
25	Sun Yat-sen UniversityChina	51.4	11.2%	2.5×	66	+22.5%
26	ShanghaiTech UniversityChina	51.3	11.9%	10.2×	24	+47.1%
27	Rockefeller UniversityUnited States	51.2	12.9%	22.5×	18	+0.9%
28	South China Agricultural UniversityChina	51.0	14.7%	5.6×	25	+44.2%
29	Tsinghua UniversityChina	50.6	14.9%	1.2×	37	+23.4%
30	Southern University of Science and TechnologyChina	50.5	17.2%	2.3×	16	+177.1%
31	Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina	50.0	11.3%	3.5×	48	+125.1%
32	Fudan UniversityChina	49.9	14.1%	2.1×	43	+50.1%
33	Weizmann Institute of ScienceIsrael	49.8	16.1%	7.2×	13	+0.2%
34	University of California, RiversideUnited States	49.7	14.7%	7.0×	26	+56.4%
35	Duke UniversityUnited States	49.6	11.3%	3.6×	38	+14.8%
36	University of California, San FranciscoUnited States	49.4	14.8%	4.1×	38	-20.9%
37	University College LondonUnited Kingdom	49.3	10.2%	2.2×	45	+10.4%
38	University of ConnecticutUnited States	49.2	19.6%	2.9×	17	+41.8%
39	Wageningen University & ResearchNetherlands	48.5	14.7%	5.2×	24	-11.6%
40	Columbia UniversityUnited States	48.3	15.8%	2.9×	40	-23.2%
41	Johns Hopkins UniversityUnited States	47.8	10.2%	2.8×	56	-8.0%
42	National University of SingaporeSingapore	46.9	9.1%	1.8×	27	+20.9%
43	Shantou UniversityChina	46.2	19.5%	3.2×	9	+397.1%
44	California Institute of TechnologyUnited States	45.3	16.3%	3.2×	15	-9.9%
45	Oncode InstituteNetherlands	43.3	14.0%	22.1×	8	-15.6%
46	Sanya UniversityChina	41.7	15.1%	7.3×	12	-
47	University of Hong KongChina	41.5	10.3%	1.6×	19	+5.2%
48	University of Agriculture FaisalabadPakistan	41.1	3.5%	8.5×	18	+62.9%
49	ETH ZurichSwitzerland	40.8	15.6%	2.3×	20	-29.2%
50	University of Electronic Science and Technology of ChinaChina	40.3	18.7%	0.6×	8	+25.0%
51	BOKU UniversityAustria	37.5	7.1%	6.6×	9	+21.8%
52	Hong Kong University of Science and TechnologyChina	37.1	9.4%	1.6×	8	+133.1%
53	Chinese University of Hong KongChina	35.2	17.1%	1.1×	10	-18.4%
54	University of North Carolina at Chapel HillUnited States	34.5	2.9%	2.6×	59	-26.6%
55	Karolinska InstitutetSweden	31.4	6.1%	2.3×	17	-20.4%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in CRISPR and Genetic Engineering, country by country

Is CRISPR and Genetic Engineering research growing?

Output in 2022-2025 was 14% higher than in 2018-2021, peaking in 2022. The fastest-growing topics are CRISPR and Genetic Engineering.

grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is CRISPR and Genetic Engineering as a percentage of every work published that year, 0.063% in 2024.

Fractional works of CRISPR and Genetic Engineering over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

Questions people ask

Who leads CRISPR and gene-editing research?

By volume in 2022-now, Chinese Academy of Sciences publishes the most CRISPR and Genetic Engineering research, followed by Chinese Academy of Agricultural Sciences and Harvard University. By volume, the United States and China publish the most (3.9k and 3.7k works in 2022-now).

Who are the leading researchers in CRISPR and gene editing?

The most-cited researchers publishing on CRISPR and Genetic Engineering include Eric S. Lander, Rob Knight and Richard M. Durbin.

Who are the leading researchers in CRISPR and Genetic Engineering?

All 1,273 questions in the Question Catalogue

Discussion

Ask a question or share a note about CRISPR and Genetic Engineering. Posts are plain text and can be reported.

Which countries lead CRISPR and Genetic Engineering research?

By volume, 2022-now

How concentrated that is

Which institutions lead CRISPR and Genetic Engineering research?

By volume, 2022-now

Who are the leading researchers in CRISPR and Genetic Engineering?

What are the most cited papers in CRISPR and Genetic Engineering?

Where is CRISPR and Genetic Engineering research done?

Largest cities, 2022-now

Where it is the local speciality

Where is the best place to study CRISPR and Genetic Engineering?

Is CRISPR and Genetic Engineering research growing?

Its share of all research

How much of it reaches the world top 10%

Which topics inside it are moving

Related research

Questions people ask

Who leads CRISPR and gene-editing research?

Who are the leading researchers in CRISPR and gene editing?

Discussion