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Topic · Genetics

Blood disorders and treatments

Blood disorders and treatments is a research topic within Genetics. Science Explorer counts 23k research works in it since 1950. 10.2% of them reached the world's top 10% most cited for their field and year.

This cluster of papers focuses on the genetic basis and clinical manifestations of various neutropenia disorders, including Shwachman-Diamond syndrome, Kostmann disease, and Cohen syndrome. It explores the impact of mutations in genes such as ELANE, HAX1, GFI1, and SBDS on neutrophil development and function, as well as the implications for hematopoietic stem cell transplantation and G-CSF therapy. The research also delves into the molecular mechanisms underlying neutropenia and potential therapeutic targets.

  • Neutropenia
  • Genetic Mutations
  • Congenital Disorders
  • G-CSF Therapy
  • ELANE Gene
  • Hematopoietic Stem Cells
  • Shwachman-Diamond Syndrome
  • HAX1 Deficiency
  • Gfi1 Transcription Factor
  • SBDS Gene
Research works
23k
fractional, since 1950
In the world top 10%
2.4k
per year above
Top-10% rate
10.2%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
+2%
the tick is no change
Largest producer
United States
36% of the 10 largest, 2022-now
Blood disorders and treatments

Which countries lead Blood disorders and treatments research?

By volume, the United States and China publish the most (879 and 383 works in 2022-now).

By volume, 2022-now

  1. 1 United States 879 works
  2. 2 China 383 works
  3. 3 India 213 works
  4. 4 Japan 176 works
  5. 5 Germany 172 works
  6. 6 France 132 works
  7. 7 Italy 129 works
  8. 8 United Kingdom 118 works
  9. 9 Brazil 104 works
  10. 10 Spain 102 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

United States: 36.5%China: 15.9%India: 8.9%Japan: 7.3%6 others listed: 31.5%36%largest
United States879 · 36.5%China383 · 15.9%India213 · 8.9%Japan176 · 7.3%6 others listed758 · 31.5%

Shares of the rows listed above, not of the whole node.

Which institutions lead Blood disorders and treatments research?

By volume in 2022-now, Harvard University publishes the most Blood disorders and treatments research, followed by National Institutes of Health and Mayo Clinic.

By volume, 2022-now

  1. 1 Harvard UniversityUnited States 36 works
  2. 2 National Institutes of HealthUnited States 27 works
  3. 3 Mayo ClinicUnited States 23 works
  4. 4 InsermFrance 22 works
  5. 5 Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 21 works
  6. 6 All India Institute of Medical SciencesIndia 19 works
  7. 7 Université Paris CitéFrance 15 works
  8. 8 University of TorontoCanada 15 works
  9. 9 University of CincinnatiUnited States 15 works
  10. 10 The University of Texas MD Anderson Cancer CenterUnited States 13 works

Who are the leading researchers in Blood disorders and treatments?

The most-cited researchers publishing on Blood disorders and treatments include David Moher, Mark J. Daly and Elaine R. Mardis.

  1. 1 David Moher Canada 898k citations
  2. 2 Mark J. Daly United States 403k citations
  3. 3 Elaine R. Mardis United States 346k citations
  4. 4 Gregory Y.H. Lip United Kingdom 311k citations
  5. 5 Lesley A. Stewart United Kingdom 308k citations
  6. 6 Dan J. Stein South Africa 306k citations
  7. 7 Richard A. Gibbs United States 292k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Blood disorders and treatments?

The most cited paper in Blood disorders and treatments is "Azacitidine and Venetoclax in Previously Untreated Acute Myeloid Leukemia" (Courtney Denton Dinardo et al., 2020), with 2,918 citations. Next come "Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease" (2,713) and "Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study" (2,681).

Most cited papers
#PaperReleasedCitations
1 Azacitidine and Venetoclax in Previously Untreated Acute Myeloid Leukemia Courtney Denton Dinardo et al. · New England Journal of Medicine Open access 12 Aug 2020 2,918
2 Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease Siddhartha Jaiswal et al. · New England Journal of Medicine Open access 21 Jun 2017 2,713
3 Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study Pierre Fenaux, Ghulam J. Mufti, Eva Hellström‐Lindberg et al. · The Lancet Oncology Open access 22 Feb 2009 2,681
4 Extracellular DNA traps promote thrombosis Tobias A. Fuchs, Alexander G. Brill, Daniel Duerschmied et al. · Proceedings of the National Academy of Sciences Open access 23 Aug 2010 2,500
5 Inborn errors of type I IFN immunity in patients with life-threatening COVID-19 Qian Zhang et al. · Science Open access746 authors 24 Sep 2020 2,421
All 100 most cited papers, with filters and sorting

Where is Blood disorders and treatments research done?

The largest centres of Blood disorders and treatments research in 2022-now are Beijing (China), Paris (France), New York (United States) and Tokyo (Japan). Among places with at least 20 works in it, it is an unusually large share of all research in Bethesda.

Largest cities, 2022-now

  1. 1 BeijingChina 61 works
  2. 2 ParisFrance 59 works
  3. 3 New YorkUnited States 47 works
  4. 4 TokyoJapan 43 works
  5. 5 LondonUnited Kingdom 40 works
  6. 6 BostonUnited States 37 works
  7. 7 MoscowRussia 36 works
  8. 8 ShanghaiChina 32 works
  9. 9 São PauloBrazil 31 works
  10. 10 HoustonUnited States 30 works

Where it is the local speciality

  1. BethesdaUS · 27.7 works6.7×
← less than its size predicts1×more →

Location quotient: how much more of its research is in Blood disorders and treatments than the world average.

See Blood disorders and treatments on the map

Where is the best place to study Blood disorders and treatments?

Among universities, judged by research, Harvard University, University of Michigan and Université Paris Cité score highest, combining citation excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%10%20%30%mean 18.12%fractional works in this field (log) →share of work in the world top 10% →University of MichiganHarvard UniversityUniversity of TorontoUniversité Paris Cité
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Citation excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Harvard UniversityUnited States 87.319.9%3.8×36 +9.0%
2University of MichiganUnited States 56.423.1%2.4×11 +11.3%
3Université Paris CitéFrance 56.216.6%6.5×15 +4.6%
4University of TorontoCanada 56.217.8%2.4×15 -14.2%
5Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 54.012.2%6.4×20 +62.8%
6Karolinska InstitutetSweden 52.719.0%5.0×9 -24.2%
7Peking UniversityChina 51.617.7%1.9×12 +42.2%
8Stanford UniversityUnited States 49.927.0%2.0×9 -10.4%
9University of WashingtonUnited States 47.510.1%2.8×10 +19.1%
10Nanjing Medical UniversityChina 47.217.8%3.8×10 +66.3%

Universities only. The score blends citation excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Blood disorders and treatments, country by country

Is Blood disorders and treatments research growing?

Output in 2022-2025 was 2% higher than in 2018-2021, peaking in 2025. The fastest-growing topics are Blood disorders and treatments.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Blood disorders and treatments as a percentage of every work published that year, 0.014% in 2024.

still counting0.020%0.040%0.060%Blood disorders and treatments0.015% in 202519801990200020102020

Fractional works of Blood disorders and treatments over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Blood disorders and treatments10.1% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

Discussion

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