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Topic · Molecular Biology

Protein Kinase Regulation and GTPase Signaling

Protein Kinase Regulation and GTPase Signaling is a research topic within Molecular Biology. Science Explorer counts 31k research works in it since 1952. 24.5% of them reached the world's top 10% most cited for their field and year.

This cluster of papers focuses on the molecular mechanisms of Ras signaling pathways, including the role of protein kinases, GTPases, and phospholipase C in cell regulation and cancer therapy. It explores the involvement of calcium signaling, cell migration, and transcriptional regulation in oncogenic mutations.

  • Ras Signaling
  • Protein Kinases
  • GTPases
  • Cell Regulation
  • Cancer Therapy
  • Calcium Signaling
  • Phospholipase C
  • Cell Migration
  • Oncogenic Mutations
  • Transcriptional Regulation
Research works
31k
fractional, since 1952
In the world top 10%
7.5k
per year above
Top-10% rate
24.5%
share of its works in the world top 10%
Growth, 2013–17 → 2018–22
-25%
the tick is no change

Which countries lead Protein Kinase Regulation and GTPase Signaling research?

By volume, the United States and China publish the most (543 and 388 works in 2022–2025).

By volume, 2022–2025

  1. 1 United States 543 works
  2. 2 China 388 works
  3. 3 Japan 118 works
  4. 4 Germany 103 works
  5. 5 India 88 works
  6. 6 United Kingdom 68 works
  7. 7 Italy 50 works
  8. 8 Spain 43 works
  9. 9 South Korea 40 works
  10. 10 France 39 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

United States: 36.7%China: 26.2%Japan: 8.0%Germany: 6.9%6 others listed: 22.2%37%largest
United States543 · 36.7%China388 · 26.2%Japan118 · 8.0%Germany103 · 6.9%6 others listed329 · 22.2%

Shares of the rows listed above, not of the whole node.

Which institutions lead Protein Kinase Regulation and GTPase Signaling research?

By volume in 2022–2025, University of North Carolina at Chapel Hill publishes the most Protein Kinase Regulation and GTPase Signaling research, followed by Purdue University West Lafayette and University of California San Diego.

By volume, 2022–2025

  1. 1 University of North Carolina at Chapel HillUnited States 14 works
  2. 2 Purdue University West LafayetteUnited States 11 works
  3. 3 University of California San DiegoUnited States 10 works
  4. 4 University of PittsburghUnited States 10 works
  5. 5 Frederick National Laboratory for Cancer ResearchUnited States 9 works
  6. 6 University of MichiganUnited States 7 works
  7. 7 Shanghai Jiao Tong UniversityChina 7 works
  8. 8 China Pharmaceutical UniversityChina 7 works
  9. 9 Yale UniversityUnited States 7 works
  10. 10 The University of Texas MD Anderson Cancer CenterUnited States 6 works

Who are the leading researchers in Protein Kinase Regulation and GTPase Signaling?

The most-cited researchers publishing on Protein Kinase Regulation and GTPase Signaling include Gordon B. Mills and Yasutomi Nishizuka.

  1. 1 Gordon B. Mills United States 3.7k citations
  2. 2 Yasutomi Nishizuka Japan 3.1k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

Where is Protein Kinase Regulation and GTPase Signaling research done?

The largest centres of Protein Kinase Regulation and GTPase Signaling research in 2022–2025 are Beijing (China), Shanghai (China), Tokyo (Japan) and New York (United States).

Largest cities, 2022–2025

  1. 1 Beijing China 41 works
  2. 2 Shanghai China 41 works
  3. 3 Tokyo Japan 34 works
  4. 4 New York United States 27 works
  5. 5 Guangzhou China 25 works
  6. 6 Nanjing China 22 works
  7. 7 Boston United States 20 works
  8. 8 London United Kingdom 19 works
  9. 9 Hangzhou China 18 works
  10. 10 San Diego United States 17 works
See Protein Kinase Regulation and GTPase Signaling on the map

Where is the best place to study Protein Kinase Regulation and GTPase Signaling?

Among universities, judged by research, Purdue University West Lafayette, University of California San Diego and University of Pittsburgh score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%5%10%15%mean 8.5%fractional works in this node (log) →share in the world top 10% →Purdue University West Lafayette: 11, 3.4%University of California San Diego: 10, 12.5%University of Pittsburgh: 10, 9.2%University of North Carolina at Chapel Hill: 14, 8.9%University of Califo…University of Pittsb…University of North …Purdue University We…
above the meannear itbelow it

One dot per university in the table below. The upper left is the interesting corner: small places doing unusually strong work.

#UniversityScoreTop 10%SpecialisationWorksGrowth
1 Purdue University West LafayetteUnited States 35.33.4%6.3×11 +178.4%
2 University of California San DiegoUnited States 32.212.5%6.8×10 -11.3%
3 University of PittsburghUnited States 26.19.2%7.3×10 -32.1%
4 University of North Carolina at Chapel HillUnited States 25.28.9%4.6×14 -10.4%

Universities only. Score blends excellence (30%), specialisation (25%), size (20%), growth (15%) and international reach (10%), 2015–2022; growth compares 2010–14 with 2015–19.

Is Protein Kinase Regulation and GTPase Signaling research growing?

Output in 2018–2022 was 25% lower than in 2013–2017, peaking in 2000.

19801990200020102020
grewheldshrank

The same series as a ribbon — one cell per year, darker for more. The line above answers how much; this answers when.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.