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Company · Cambridge · United States

Sage Therapeutics (United States)

sagerx.comROR OpenAlex
World rank, all time
#28,381
of 34,923
Rank in United States
#5,953
of 7,310
Research works
152
▼ 27% vs 2018-21
Citations
3.3k
21.8 per fractional work
Top-10% rate
12.6%
all institutions 10.0%
vs its own fields
1.05×
1.00× is exactly expected
Open access
47%
world 40%
International
20%
world 18%
Sage Therapeutics (United States)

Which fields of science does Sage Therapeutics (United States) work in?

In 2022-now, 46% of research at Sage Therapeutics (United States) is in Life Sciences, 40% in Health Sciences. Its largest fields are Medicine (37%), Neuroscience (28%), Biochemistry, Genetics and Molecular Biology (15%). It does 2.7× the world's share of Life Sciences.

Life Sciences: 23 fractional works · 45.9% of its workNeuroscience: 14 fractional works · 27.6% of its workCellular and Molecular Neuroscience: 9 fractional works · 18.2% of its workCognitive Neuroscience: 2 fractional works · 3.7% of its workNeurology: 1 fractional works · 2.0% of its workBiological Psychiatry: 1 fractional works · 1.6% of its workBehavioral Neuroscience: 1 fractional works · 1.1% of its workSensory Systems: 0 fractional works · 0.5% of its workEndocrine and Autonomic Systems: 0 fractional works · 0.4% of its workDevelopmental Neuroscience: 0 fractional works · 0.2% of its workBiochemistry, Genetics and Molecular Biology: 8 fractional works · 15.1% of its workMolecular Biology: 6 fractional works · 11.5% of its workCancer Research: 1 fractional works · 1.1% of its workBiophysics: 0 fractional works · 1.0% of its workClinical Biochemistry: 0 fractional works · 0.5% of its workGenetics: 0 fractional works · 0.4% of its workBiotechnology: 0 fractional works · 0.3% of its workSmaller subfields together: 0 fractional works · 0.3% of its workImmunology and Microbiology: 1 fractional works · 2.1% of its workImmunology: 1 fractional works · 2.1% of its workPharmacology, Toxicology and Pharmaceutics: 0 fractional works · 0.9% of its workToxicology: 0 fractional works · 0.8% of its workSmaller subfields together: 0 fractional works · 0.1% of its workAgricultural and Biological Sciences: 0 fractional works · 0.3% of its workHealth Sciences: 20 fractional works · 40.3% of its workMedicine: 19 fractional works · 37.3% of its workNeurology: 5 fractional works · 9.5% of its workPharmacology: 3 fractional works · 6.0% of its workPsychiatry and Mental health: 2 fractional works · 4.0% of its workPublic Health, Environmental and Occupational Health: 1 fractional works · 2.9% of its workEpidemiology: 1 fractional works · 1.7% of its workPulmonary and Respiratory Medicine: 1 fractional works · 1.7% of its workEndocrinology, Diabetes and Metabolism: 1 fractional works · 1.6% of its workOncology: 1 fractional works · 1.5% of its workPhysiology: 1 fractional works · 1.4% of its workSurgery: 1 fractional works · 1.4% of its workRheumatology: 1 fractional works · 1.2% of its workPediatrics, Perinatology and Child Health: 1 fractional works · 1.1% of its workInfectious Diseases: 0 fractional works · 0.9% of its workPathology and Forensic Medicine: 0 fractional works · 0.8% of its workCardiology and Cardiovascular Medicine: 0 fractional works · 0.4% of its workHematology: 0 fractional works · 0.4% of its workGeriatrics and Gerontology: 0 fractional works · 0.3% of its workSmaller subfields together: 0 fractional works · 0.4% of its workHealth Professions: 1 fractional works · 2.7% of its workGeneral Health Professions: 1 fractional works · 1.6% of its workPhysical Therapy, Sports Therapy and Rehabilitation: 0 fractional works · 1.0% of its workSmaller subfields together: 0 fractional works · 0.1% of its workNursing: 0 fractional works · 0.3% of its workNutrition and Dietetics: 0 fractional works · 0.3% of its workSocial Sciences: 5 fractional works · 9.7% of its workPsychology: 3 fractional works · 6.7% of its workExperimental and Cognitive Psychology: 1 fractional works · 2.8% of its workSocial Psychology: 1 fractional works · 1.8% of its workClinical Psychology: 1 fractional works · 1.2% of its workApplied Psychology: 0 fractional works · 0.7% of its workSmaller subfields together: 0 fractional works · 0.2% of its workSocial Sciences: 1 fractional works · 1.5% of its workHealth: 1 fractional works · 1.0% of its workSociology and Political Science: 0 fractional works · 0.3% of its workSmaller subfields together: 0 fractional works · 0.2% of its workEconomics, Econometrics and Finance: 0 fractional works · 0.8% of its workEconomics and Econometrics: 0 fractional works · 0.8% of its workDecision Sciences: 0 fractional works · 0.7% of its workStatistics, Probability and Uncertainty: 0 fractional works · 0.7% of its workPhysical Sciences: 2 fractional works · 4.1% of its workComputer Science: 1 fractional works · 1.8% of its workComputational Theory and Mathematics: 1 fractional works · 1.3% of its workArtificial Intelligence: 0 fractional works · 0.5% of its workMathematics: 1 fractional works · 1.1% of its workStatistics and Probability: 0 fractional works · 1.0% of its workSmaller subfields together: 0 fractional works · 0.1% of its workChemistry: 0 fractional works · 0.4% of its workSpectroscopy: 0 fractional works · 0.4% of its workEngineering: 0 fractional works · 0.3% of its workElectrical and Electronic Engineering: 0 fractional works · 0.2% of its workSmaller subfields together: 0 fractional works · 0.1% of its workMaterials Science: 0 fractional works · 0.3% of its workElectronic, Optical and Magnetic Materials: 0 fractional works · 0.2% of its workSmaller subfields together: 0 fractional works · 0.1% of its workEnergy: 0 fractional works · 0.2% of its workRenewable Energy, Sustainability and the Environment: 0 fractional works · 0.2% of its workALL ITS WORKSage Therapeutics(United States)51fractional works, 2022-now
Life Sciences46%Physical Sciences4%Health Sciences40%Social Sciences10%

Each ring splits the one inside it: the four domains of science, their fields, their subfields. Size is fractional works in 2022-now. Every slice is a page; the interactive view zooms down to single topics and colours each by how much more of it this institution does than the world.

Its 4 domains and 19 fields, with their numbers
    1. Neuroscience1427.6%
    2. Biochemistry, Genetics and Molecular Biology815.1%
    3. Immunology and Microbiology12.1%
    4. Pharmacology, Toxicology and Pharmaceutics00.9%
    5. Agricultural and Biological Sciences00.3%
    1. Medicine1937.3%
    2. Health Professions12.7%
    3. Nursing00.3%
    1. Psychology36.7%
    2. Social Sciences11.5%
    3. Economics, Econometrics and Finance00.8%
    4. Decision Sciences00.7%
    1. Computer Science11.8%
    2. Mathematics11.1%
    3. Chemistry00.4%
    4. Engineering00.3%
    5. Materials Science00.3%
    6. Energy00.2%
    7. Environmental Science00.0%
All of science, and how each field's share has moved since 1950: the Science domain explorer

Field profile

Location quotient across every field it publishes in: outside the ring is more than an institution of this size would be expected to publish, inside it is less.

Agricultural and Biological Sciences: 0.06× its world share, 0 worksAgricultural and Bio…Biochemistry, Genetics and Molecular Biology: 2.83× its world share, 8 worksBiochemistry, Geneti…Immunology and Microbiology: 2.05× its world share, 1 worksImmunology and Micro…Neuroscience: 17.02× its world share, 14 worksNeurosciencePharmacology, Toxicology and Pharmaceutics: 2.51× its world share, 0 worksPharmacology, Toxico…Chemistry: 0.25× its world share, 0 worksChemistryComputer Science: 0.23× its world share, 1 worksComputer ScienceEnergy: 0.24× its world share, 0 worksEnergyEngineering: 0.02× its world share, 0 worksEngineeringMaterials Science: 0.08× its world share, 0 worksMaterials ScienceMathematics: 0.91× its world share, 0 worksMathematicsHealth Professions: 1.02× its world share, 1 worksHealth ProfessionsMedicine: 1.94× its world share, 19 worksMedicineNursing: 0.59× its world share, 0 worksNursingDecision Sciences: 0.73× its world share, 0 worksDecision SciencesEconomics, Econometrics and Finance: 0.38× its world share, 0 worksEconomics, Econometr…Psychology: 2.18× its world share, 3 worksPsychologySocial Sciences: 0.12× its world share, 1 worksSocial Sciences1×world share
more than its size predictsabout as predictedless

Rings at 0.5×, 1× and 2×. Widest outward: Neuroscience, 17.0×. Every wedge is a field page.

All 18 fields, with their numbers
  1. Neuroscience17.02×14 works
  2. Biochemistry, Genetics and Molecular Biology2.83×8 works
  3. Pharmacology, Toxicology and Pharmaceutics2.51×0 works
  4. Psychology2.18×3 works
  5. Immunology and Microbiology2.05×1 works
  6. Medicine1.94×19 works
  7. Health Professions1.02×1 works
  8. Mathematics0.91×0 works
  9. Decision Sciences0.73×0 works
  10. Nursing0.59×0 works
  11. Economics, Econometrics and Finance0.38×0 works
  12. Chemistry0.25×0 works
  13. Energy0.24×0 works
  14. Computer Science0.23×1 works
  15. Social Sciences0.12×1 works
  16. Materials Science0.08×0 works
  17. Agricultural and Biological Sciences0.06×0 works
  18. Engineering0.02×0 works

Who are the top researchers at Sage Therapeutics (United States)?

Ranked on the quality score, James Doherty, Michael C. Quirk and Ethan C. Hoffmann lead among researchers whose main affiliation is Sage Therapeutics (United States).

  1. 1 James Doherty United States · #263,315 worldwide 5.1k citations · 91 works
  2. 2 Michael C. Quirk United States · #291,911 worldwide 5.3k citations · 59 works
  3. 3 Ethan C. Hoffmann United States · #312,323 worldwide 2.9k citations · 59 works
  4. 4 Rebecca Hammond United States · #312,437 worldwide 4.6k citations · 60 works
  5. 5 Stephen Kanes United States · #530,417 worldwide 6.4k citations · 112 works
  6. 6 Abdul J. Sankoh United States · #561,202 worldwide 6.3k citations · 63 works
  7. 7 Robert A. Lasser United States · #1,052,916 worldwide 6.6k citations · 130 works
  8. 8 Jeffrey Wald United States · #1,121,254 worldwide 905 citations · 21 works
  9. 9 Michael Lewis United States · #1,220,124 worldwide 658 citations · 41 works
  10. 10 Margaret E. Gerbasi United States · #1,403,781 worldwide 1.1k citations · 50 works
All ranked researchers at Sage Therapeutics (United States)

What are the most cited papers from Sage Therapeutics (United States)?

The most cited paper from Sage Therapeutics (United States) is "Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1" (Daniel J. Klionsky et al., 2021), with 2,743 citations. Next come "Brexanolone injection in post-partum depression: two multicentre, double-blind, randomised, placebo-controlled, phase 3 trials" (800) and "Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia" (496).

Most cited papers
#PaperReleasedCitations
1 Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1 Daniel J. Klionsky et al. · Autophagy Open access2,930 authors 2 Jan 2021 2,743
2 Brexanolone injection in post-partum depression: two multicentre, double-blind, randomised, placebo-controlled, phase 3 trials Samantha E Meltzer-Brody, Helen Colquhoun, Robert A. Riesenberg et al. · The Lancet 31 Aug 2018 800
3 Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia Adriana E. Tron et al. · Nature Communications Open access 11 Dec 2018 496
4 Brexanolone (SAGE-547 injection) in post-partum depression: a randomised controlled trial Stephen Kanes, Helen Colquhoun, Handan Gunduz‐Bruce et al. · The Lancet 13 Jun 2017 484
5 Efficacy and Safety of Lisdexamfetamine for Treatment of Adults With Moderate to Severe Binge-Eating Disorder Susan L. McElroy, James I. Hudson, James Earl Mitchell et al. · JAMA Psychiatry 14 Jan 2015 321
All 60 most cited papers, with filters and sorting

Which keywords describe research at Sage Therapeutics (United States)?

By fractional works in 2022-now, weighted toward what it does more of than the world: Mitochondrial Dysfunction, Protein Aggregation, Huntington's Disease, Polyglutamine, Depression, Neurological Disorders, Synaptic Plasticity and Treatment-Resistant Depression.

▲ more of its work than of the world's◆ about the world's share▼ less than the world's

Size is fractional works in 2022-now in the topics tagged with each word; colour is the word's share of this institution's work against its share of the world's. The 40 words are chosen for being large and distinctive. Each links to the topic it comes from most.

All 40 words, with their numbers
  1. Mitochondrial Dysfunction8▲ 56×3 topics
  2. Huntington's Disease6▲ 412×1 topic
  3. Polyglutamine6▲ 412×1 topic
  4. Protein Aggregation6▲ 238×2 topics
  5. Depression5▲ 12×12 topics
  6. Neurological Disorders5▲ 18×10 topics
  7. Synaptic Plasticity4▲ 38×3 topics
  8. Treatment-Resistant Depression4▲ 112×2 topics
  9. Cognitive Impairment3▲ 26×7 topics
  10. Parkinson's Disease3▲ 26×4 topics
  11. Oxidative Stress3▲ 3.8×9 topics
  12. Alzheimer's Disease3▲ 21×5 topics
  13. Neurodegeneration3▲ 17×4 topics
  14. Epilepsy2▲ 40×3 topics
  15. Neurobiology2▲ 17×7 topics
  16. Basal Ganglia2▲ 75×2 topics
  17. Dendritic Spines2▲ 54×2 topics
  18. NMDA Receptor2▲ 104×2 topics
  19. Antidepressant2▲ 158×1 topic
  20. GABAergic2▲ 81×1 topic
  21. Ketamine2▲ 158×1 topic
  22. Metabolism2▲ 7.3×6 topics
  23. Neurotransmission2▲ 81×1 topic
  24. Diagnostic Criteria2▲ 16×4 topics
  25. Pharmacology2▲ 14×2 topics
  26. Biomarkers2▲ 4.7×3 topics
  27. Deep Brain Stimulation2▲ 49×1 topic
  28. Meta-Analysis2▲ 5.8×7 topics
  29. Subthalamic Nucleus2▲ 83×1 topic
  30. Dopaminergic Neurons2▲ 48×1 topic
  31. Prefrontal Cortex2▲ 36×3 topics
  32. Schizophrenia2▲ 28×4 topics
  33. a-Synuclein2▲ 59×1 topic
  34. Cell Signaling2▲ 19×5 topics
  35. Neuroimaging2▲ 11×3 topics
  36. Toxicology2▲ 17×2 topics
  37. Crystal Structure1▲ 19×2 topics
  38. Health Outcomes1▲ 9.5×3 topics
  39. Hippocampus1▲ 40×2 topics
  40. Psychological Interventions1▲ 19×2 topics

Which research topics does Sage Therapeutics (United States) publish most on?

By volume in 2022-now: Genetic Neurodegenerative Diseases, Treatment of Major Depression, Neuroscience and Neuropharmacology Research and Neurological disorders and treatments.

Genetic Neurodegenerativ…6Genetic Neurodegenerative Diseases: 6 fractional worksTreatment of Major Depre…2Treatment of Major Depression: 2 fractional worksNeuroscience and Neuroph…2Neuroscience and Neuropharmacology Research: 2 fractional worksNeurological disorders and treatments: 2 fractional worksParkinson's Disease Mechanisms and Treatments: 2 fractional worksMaternal Mental Health D…1Maternal Mental Health During Pregnancy and Postpartum: 1 fractional worksDementia and Cognitive Impairment Research: 1 fractional worksCholinesterase and Neurodegenerative Diseases: 1 fractional worksTryptophan and brain disorders: 1 fractional worksReceptor Mechanisms and Signaling: 1 fractional works
Cellular and Molecular NeurosciencePharmacologyNeurologyPublic Health, Environmental and Occupational Health3 others

Area is fractional works; colour is the subfield each topic belongs to.

  1. 1 Genetic Neurodegenerative Diseases Cellular and Molecular Neuroscience 6 works
  2. 2 Treatment of Major Depression Pharmacology 2 works
  3. 3 Neuroscience and Neuropharmacology Research Cellular and Molecular Neuroscience 2 works
  4. 4 Neurological disorders and treatments Neurology 2 works
  5. 5 Parkinson's Disease Mechanisms and Treatments Neurology 2 works
  6. 6 Maternal Mental Health During Pregnancy and Postpartum Public Health, Environmental and Occupational Health 1 works
  7. 7 Dementia and Cognitive Impairment Research Psychiatry and Mental health 1 works
  8. 8 Cholinesterase and Neurodegenerative Diseases Pharmacology 1 works
  9. 9 Tryptophan and brain disorders Biological Psychiatry 1 works
  10. 10 Receptor Mechanisms and Signaling Molecular Biology 1 works

How open and international is its research?

Against the world's own shares: the tick on each track. Both are shares of its output, so they sit on one scale and can be read against each other as well as against the world.

openly available46.7%not open53.3%

World: 40% of research is openly available.

with international co-authors19.8%domestic only80.2%

World: 18% is written across borders.

How has Sage Therapeutics (United States)'s research output changed?

Output in 2022-2025 was 27% lower than in 2018-2021.

still counting1990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Sage Therapeutics (United States) as a percentage of every work published that year, 0.00020% in 2024.

still counting0.00020%0.00040%0.00060%Sage Therapeutics (United States)0.00012% in 20251990200020102020

Fractional works of Sage Therapeutics (United States) over all fractional works that year. How the balance of science has shifted.

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Sage Therapeutics (United States) on Science Explorer

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