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Topic · Molecular Biology

Peroxisome Proliferator-Activated Receptors

Peroxisome Proliferator-Activated Receptors is a research topic within Molecular Biology. Science Explorer counts 35k research works in it since 1950. 9.9% of them reached the world's top 10% most cited for their field and year.

This cluster of papers focuses on the Peroxisome Proliferator-Activated Receptors (PPARs), a group of nuclear receptors that play a crucial role in regulating metabolism, inflammation, lipid physiology, and various metabolic diseases such as obesity and diabetes. The cluster explores the diverse biology, mechanisms of action, and therapeutic implications of PPARs, including their involvement in transcriptional regulation and the role of fatty acid-binding proteins.

  • Peroxisome Proliferator-Activated Receptors
  • PPARs
  • metabolism
  • inflammation
  • lipid
  • nuclear receptors
  • obesity
  • diabetes
  • fatty acid-binding proteins
  • transcriptional regulation
Research works
35k
fractional, since 1950
In the world top 10%
3.4k
per year above
Top-10% rate
9.9%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
-5%
the tick is no change
Largest producer
China
47% of the 10 largest, 2022-now
Peroxisome Proliferator-Activated Receptors

Which countries lead Peroxisome Proliferator-Activated Receptors research?

By volume, China and the United States publish the most (1.5k and 712 works in 2022-now).

By volume, 2022-now

  1. 1 China 1.5k works
  2. 2 United States 712 works
  3. 3 Japan 213 works
  4. 4 India 186 works
  5. 5 Germany 128 works
  6. 6 South Korea 113 works
  7. 7 Italy 82 works
  8. 8 United Kingdom 78 works
  9. 9 France 76 works
  10. 10 Canada 71 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

China: 46.9%United States: 22.8%Japan: 6.8%India: 6.0%6 others listed: 17.5%47%largest
China1,465 · 46.9%United States712 · 22.8%Japan213 · 6.8%India186 · 6.0%6 others listed548 · 17.5%

Shares of the rows listed above, not of the whole node.

Which institutions lead Peroxisome Proliferator-Activated Receptors research?

By volume in 2022-now, Shanghai Jiao Tong University publishes the most Peroxisome Proliferator-Activated Receptors research, followed by Chinese Academy of Agricultural Sciences and Harvard University.

By volume, 2022-now

  1. 1 Shanghai Jiao Tong UniversityChina 30 works
  2. 2 Chinese Academy of Agricultural SciencesChina 28 works
  3. 3 Harvard UniversityUnited States 27 works
  4. 4 Chinese Academy of SciencesChina 26 works
  5. 5 Zhejiang UniversityChina 25 works
  6. 6 Sun Yat-sen UniversityChina 23 works
  7. 7 Sichuan UniversityChina 23 works
  8. 8 Nanjing Medical UniversityChina 21 works
  9. 9 Fudan UniversityChina 20 works
  10. 10 Capital Medical UniversityChina 19 works

Who are the leading researchers in Peroxisome Proliferator-Activated Receptors?

The most-cited researchers publishing on Peroxisome Proliferator-Activated Receptors include Eric S. Lander, George Davey Smith and Walter Churchill Willett.

  1. 1 Eric S. Lander United States 524k citations
  2. 2 George Davey Smith United Kingdom 435k citations
  3. 3 Walter Churchill Willett United States 411k citations
  4. 4 Mark J. Daly United States 403k citations
  5. 5 Stacey L. Gabriel United States 402k citations
  6. 6 Guido Kroemer France 386k citations
  7. 7 Jost Bruno Jonas Germany 350k citations
  8. 8 John J.V. McMurray United Kingdom 349k citations
  9. 9 Hermann Brenner Germany 343k citations
  10. 10 Shizuo Akira Japan 342k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Peroxisome Proliferator-Activated Receptors?

The most cited paper in Peroxisome Proliferator-Activated Receptors is "Nitric Oxide and Peroxynitrite in Health and Disease" (Pál Pacher, Joseph S. Beckman, Lucas Liaudet, 2007), with 6,382 citations. Next come "Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance" (5,834) and "A Receptor-Mediated Pathway for Cholesterol Homeostasis" (5,742).

Most cited papers
#PaperReleasedCitations
1 Nitric Oxide and Peroxynitrite in Health and Disease Pál Pacher, Joseph S. Beckman, Lucas Liaudet · Physiological Reviews ReviewOpen access 2007 6,382
2 Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance Haiyan Xu, Glenn T. Barnes, Qing Yang et al. · Journal of Clinical Investigation Open access 15 Dec 2003 5,834
3 A Receptor-Mediated Pathway for Cholesterol Homeostasis Michael Scott Brown, Joseph L. Goldstein · Science 4 Apr 1986 5,742
4 Effect of Rosiglitazone on the Risk of Myocardial Infarction and Death from Cardiovascular Causes Steven E. Nissen, Kathy Wolski · New England Journal of Medicine Open access 22 May 2007 4,695
5 SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver Jay D. Horton, Joseph L. Goldstein, Michael Scott Brown · Journal of Clinical Investigation Open access May 2002 4,328
All 99 most cited papers, with filters and sorting

Where is Peroxisome Proliferator-Activated Receptors research done?

The largest centres of Peroxisome Proliferator-Activated Receptors research in 2022-now are Beijing (China), Shanghai (China), Guangzhou (China) and Wuhan (China).

Largest cities, 2022-now

  1. 1 BeijingChina 166 works
  2. 2 ShanghaiChina 105 works
  3. 3 GuangzhouChina 90 works
  4. 4 WuhanChina 63 works
  5. 5 HangzhouChina 60 works
  6. 6 NanjingChina 55 works
  7. 7 SeoulSouth Korea 46 works
  8. 8 TokyoJapan 44 works
  9. 9 ChengduChina 44 works
  10. 10 ChongqingChina 43 works
See Peroxisome Proliferator-Activated Receptors on the map

Where is the best place to study Peroxisome Proliferator-Activated Receptors?

Among universities, judged by research, Harvard University, Shanghai Jiao Tong University and Southern Medical University score highest, combining citation excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%10%20%mean 16.62%fractional works in this field (log) →share of work in the world top 10% →Southern Medical Uni…Harvard UniversityShanghai Jiao Tong U…Zhejiang University
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Citation excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Harvard UniversityUnited States 79.217.1%2.5×27 -14.0%
2Shanghai Jiao Tong UniversityChina 64.716.4%3.0×30 +1.4%
3Southern Medical UniversityChina 61.518.4%7.9×17 +56.2%
4Zhejiang UniversityChina 61.215.4%2.7×25 +6.8%
5Shanghai University of Traditional Chinese MedicineChina 61.119.7%13.4×12 +54.9%
6Peking UniversityChina 61.020.6%2.6×18 +22.4%
7Fudan UniversityChina 57.813.5%3.7×20 +27.0%
8Wuhan UniversityChina 56.719.0%3.8×18 -2.5%
9Chongqing Medical UniversityChina 56.013.8%9.3×18 +21.8%
10Anhui Medical UniversityChina 54.912.3%10.5×17 +84.9%

Universities only. The score blends citation excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Peroxisome Proliferator-Activated Receptors, country by country

Is Peroxisome Proliferator-Activated Receptors research growing?

Output in 2022-2025 was 5% lower than in 2018-2021, peaking in 2008.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Peroxisome Proliferator-Activated Receptors as a percentage of every work published that year, 0.015% in 2024.

still counting0.020%0.040%0.060%Peroxisome Proliferator-Activated Receptors0.016% in 202519801990200020102020

Fractional works of Peroxisome Proliferator-Activated Receptors over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Peroxisome Proliferator-Activated Receptors9.9% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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