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Topic · Molecular Biology

Pharmacological Receptor Mechanisms and Effects

Pharmacological Receptor Mechanisms and Effects is a research topic within Molecular Biology. Science Explorer counts 16k research works in it since 1950. 10.0% of them reached the world's top 10% most cited for their field and year.

This cluster of papers explores the role of sigma receptors, particularly the Sigma-1 receptor, in regulating cellular signaling, calcium signaling, cell survival, and their potential therapeutic implications in neuroprotection, neuropsychiatric disorders, cancer therapy, and neurodegenerative diseases.

  • Sigma-1 Receptor
  • Chaperone
  • Cell Survival
  • Neuroprotection
  • ER-Mitochondrion Interface
  • Neuropsychiatric Disorders
  • Cancer Therapy
  • Antidepressants
  • Neurodegenerative Diseases
  • Calcium Signaling
Research works
16k
fractional, since 1950
In the world top 10%
1.7k
per year above
Top-10% rate
10.0%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
+14%
the tick is no change
Largest producer
United States
38% of the 10 largest, 2022-now
Pharmacological Receptor Mechanisms and Effects

Which countries lead Pharmacological Receptor Mechanisms and Effects research?

By volume, the United States and China publish the most (683 and 387 works in 2022-now).

By volume, 2022-now

  1. 1 United States 683 works
  2. 2 China 387 works
  3. 3 India 165 works
  4. 4 Italy 110 works
  5. 5 Germany 101 works
  6. 6 United Kingdom 88 works
  7. 7 Japan 85 works
  8. 8 Iran 69 works
  9. 9 Spain 66 works
  10. 10 France 64 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

United States: 37.5%China: 21.3%India: 9.1%Italy: 6.0%6 others listed: 26.0%38%largest
United States683 · 37.5%China387 · 21.3%India165 · 9.1%Italy110 · 6.0%6 others listed474 · 26.0%

Shares of the rows listed above, not of the whole node.

Which institutions lead Pharmacological Receptor Mechanisms and Effects research?

By volume in 2022-now, National Institutes of Health publishes the most Pharmacological Receptor Mechanisms and Effects research, followed by Harvard University and Russian Academy of Sciences.

By volume, 2022-now

  1. 1 National Institutes of HealthUnited States 26 works
  2. 2 Harvard UniversityUnited States 22 works
  3. 3 Russian Academy of SciencesRussia 19 works
  4. 4 University of North Carolina at Chapel HillUnited States 18 works
  5. 5 Centre National de la Recherche ScientifiqueFrance 14 works
  6. 6 InsermFrance 12 works
  7. 7 Washington University in St. LouisUnited States 11 works
  8. 8 Sichuan UniversityChina 10 works
  9. 9 Chinese Academy of SciencesChina 10 works
  10. 10 University of TorontoCanada 10 works

Who are the leading researchers in Pharmacological Receptor Mechanisms and Effects?

The most-cited researchers publishing on Pharmacological Receptor Mechanisms and Effects include George Davey Smith, Guido Kroemer and Jun Wang.

  1. 1 George Davey Smith United Kingdom 435k citations
  2. 2 Guido Kroemer France 386k citations
  3. 3 Jun Wang China 340k citations
  4. 4 Giuseppe Remuzzi Italy 328k citations
  5. 5 Gordon Henry Guyatt Canada 315k citations
  6. 6 Dan J. Stein South Africa 306k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Pharmacological Receptor Mechanisms and Effects?

The most cited paper in Pharmacological Receptor Mechanisms and Effects is "Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China" (Chaomin Wu et al., 2020), with 8,770 citations. Next come "Remdesivir for the Treatment of Covid-19 — Final Report" (7,759) and "Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China" (7,427).

Most cited papers
#PaperReleasedCitations
1 Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China Chaomin Wu et al. · JAMA Internal Medicine Open access 13 Mar 2020 8,770
2 Remdesivir for the Treatment of Covid-19 — Final Report John H. Beigel et al. · New England Journal of Medicine Open access 22 May 2020 7,759
3 Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China Ling Mao, Huijuan Jin, Mengdie Wang et al. · JAMA Neurology Open access 10 Apr 2020 7,427
4 Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. G. Di Chiara, Assunta Impérato · Proceedings of the National Academy of Sciences Open access Jul 1988 4,770
5 Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study Tao Chen et al. · BMJ Open access 26 Mar 2020 4,166
All 98 most cited papers, with filters and sorting

Where is Pharmacological Receptor Mechanisms and Effects research done?

The largest centres of Pharmacological Receptor Mechanisms and Effects research in 2022-now are Beijing (China), New York (United States), London (United Kingdom) and Shanghai (China). Among places with at least 20 works in it, it is an unusually large share of all research in Bethesda.

Largest cities, 2022-now

  1. 1 BeijingChina 53 works
  2. 2 New YorkUnited States 33 works
  3. 3 LondonUnited Kingdom 30 works
  4. 4 ShanghaiChina 30 works
  5. 5 TehranIran 29 works
  6. 6 BethesdaUnited States 29 works
  7. 7 TokyoJapan 25 works
  8. 8 ParisFrance 24 works
  9. 9 NanjingChina 22 works
  10. 10 MoscowRussia 21 works

Where it is the local speciality

  1. BethesdaUS · 29.3 works9.4×
← less than its size predicts1×more →

Location quotient: how much more of its research is in Pharmacological Receptor Mechanisms and Effects than the world average.

See Pharmacological Receptor Mechanisms and Effects on the map

Where is the best place to study Pharmacological Receptor Mechanisms and Effects?

Among universities, judged by research, Harvard University, Washington University in St. Louis and University of Toronto score highest, combining citation excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%10%20%mean 9.54444%fractional works in this field (log) →share of work in the world top 10% →Washington Universit…Harvard UniversityUniversity of TorontoUniversity of North …
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Citation excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Harvard UniversityUnited States 76.913.1%3.0×22 +3.6%
2Washington University in St. LouisUnited States 64.222.3%6.5×11 +8.4%
3University of TorontoCanada 43.68.2%2.0×10 +0.5%
4University of North Carolina at Chapel HillUnited States 42.13.3%4.5×18 -16.4%
5Sichuan UniversityChina 41.712.2%2.0×10 +177.8%
6Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 40.215.8%3.6×9 +21.2%
7University of FloridaUnited States 31.98.7%3.7×9 -1.6%
8Virginia Commonwealth UniversityUnited States 30.51.8%11.1×8 +11.1%
9University of MünsterGermany 18.70.5%8.9×9 -8.7%

Universities only. The score blends citation excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Pharmacological Receptor Mechanisms and Effects, country by country

Is Pharmacological Receptor Mechanisms and Effects research growing?

Output in 2022-2025 was 14% higher than in 2018-2021, peaking in 2021. The fastest-growing topics are Pharmacological Receptor Mechanisms and Effects.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Pharmacological Receptor Mechanisms and Effects as a percentage of every work published that year, 0.0088% in 2024.

still counting0.020%0.040%0.060%Pharmacological Receptor Mechanisms and Effects0.011% in 202519801990200020102020

Fractional works of Pharmacological Receptor Mechanisms and Effects over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Pharmacological Receptor Mechanisms and Effects10.0% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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