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Porphyrin Metabolism and Disorders

Porphyrin Metabolism and Disorders is a research topic within Molecular Biology. Science Explorer counts 19k research works in it since 1950. 10.1% of them reached the world's top 10% most cited for their field and year.

This cluster of papers explores the molecular mechanisms of heme biosynthesis, including the catalysis by cobalamin-dependent enzymes, genetic mutations leading to porphyrias, microbial production of vitamin B12, and the use of RNA interference therapy and liver transplantation for the treatment of related disorders. It also delves into metabolic engineering and genomic analysis related to heme biosynthesis pathways.

  • Heme Biosynthesis
  • Vitamin B12
  • Porphyrias
  • Enzyme Catalysis
  • Genetic Mutations
  • Metabolic Engineering
  • RNA Interference Therapy
  • Liver Transplantation
  • Genomic Analysis
  • Biochemical Pathways
Research works
19k
fractional, since 1950
In the world top 10%
1.9k
per year above
Top-10% rate
10.1%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
+5%
the tick is no change
Largest producer
United States
35% of the 10 largest, 2022-now
Porphyrin Metabolism and Disorders

Which countries lead Porphyrin Metabolism and Disorders research?

By volume, the United States and China publish the most (416 and 200 works in 2022-now).

By volume, 2022-now

  1. 1 United States 416 works
  2. 2 China 200 works
  3. 3 India 119 works
  4. 4 Japan 94 works
  5. 5 Germany 80 works
  6. 6 United Kingdom 68 works
  7. 7 Russia 58 works
  8. 8 France 54 works
  9. 9 Spain 50 works
  10. 10 Italy 47 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

United States: 35.1%China: 16.9%India: 10.1%Japan: 7.9%6 others listed: 30.1%35%largest
United States416 · 35.1%China200 · 16.9%India119 · 10.1%Japan94 · 7.9%6 others listed357 · 30.1%

Shares of the rows listed above, not of the whole node.

Which institutions lead Porphyrin Metabolism and Disorders research?

By volume in 2022-now, Russian Academy of Sciences publishes the most Porphyrin Metabolism and Disorders research, followed by Harvard University and Centre National de la Recherche Scientifique.

Who are the leading researchers in Porphyrin Metabolism and Disorders?

The most-cited researchers publishing on Porphyrin Metabolism and Disorders include Giuseppe Remuzzi, Gregory Y.H. Lip and Jean‐Louis Vincent.

  1. 1 Giuseppe Remuzzi Italy 328k citations
  2. 2 Gregory Y.H. Lip United Kingdom 311k citations
  3. 3 Jean‐Louis Vincent Belgium 262k citations
  4. 4 Kaj Blennow Sweden 247k citations
  5. 5 John Hardy United Kingdom 243k citations
  6. 6 Richard Anthony Flavell United States 237k citations
  7. 7 Tom Maniatis United States 233k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Porphyrin Metabolism and Disorders?

The most cited paper in Porphyrin Metabolism and Disorders is "Determination of DNA base composition by reversed-phase high-performance liquid chromatography" (Jin Támaoka, Kazuo Komagata, 1984), with 2,421 citations. Next come "HOW DOES PHOTODYNAMIC THERAPY WORK?" (2,372) and "Natively unfolded proteins: A point where biology waits for physics" (1,849).

Most cited papers
#PaperReleasedCitations
1 Determination of DNA base composition by reversed-phase high-performance liquid chromatography Jin Támaoka, Kazuo Komagata · FEMS Microbiology Letters Open access Nov 1984 2,421
2 HOW DOES PHOTODYNAMIC THERAPY WORK? Barbara W. Henderson, Thomas J. Dougherty · Photochemistry and Photobiology 1992 2,372
3 Natively unfolded proteins: A point where biology waits for physics Vladimir Nikolaevich Uversky · Protein Science Open access Apr 2002 1,849
4 The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase. R Tenhunen, Harvey S. Marver, Roman Schmid · Proceedings of the National Academy of Sciences Open access Oct 1968 1,815
5 Biochemistry, Cellular and Molecular Biology, and Physiological Roles of the Iodothyronine Selenodeiodinases Antonio Carlos Bianco, Domenico Salvatore, Balázs Gereben et al. · Endocrine Reviews Feb 2002 1,804
All 99 most cited papers, with filters and sorting

Where is Porphyrin Metabolism and Disorders research done?

The largest centres of Porphyrin Metabolism and Disorders research in 2022-now are Moscow (Russia), Beijing (China), Tokyo (Japan) and London (United Kingdom).

Largest cities, 2022-now

  1. 1 MoscowRussia 30 works
  2. 2 BeijingChina 28 works
  3. 3 TokyoJapan 21 works
  4. 4 LondonUnited Kingdom 19 works
  5. 5 ParisFrance 19 works
  6. 6 New YorkUnited States 18 works
  7. 7 New DelhiIndia 15 works
  8. 8 ShanghaiChina 15 works
  9. 9 CambridgeUnited States 14 works
  10. 10 MadridSpain 13 works
See Porphyrin Metabolism and Disorders on the map

Where is the best place to study Porphyrin Metabolism and Disorders?

Among universities, judged by research, Harvard University, University of Michigan and All India Institute of Medical Sciences score highest, combining citation excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

Citation excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Harvard UniversityUnited States 90.018.0%3.1×14 +63.7%
2University of MichiganUnited States 66.618.3%4.8×10 +6.9%
3All India Institute of Medical SciencesIndia 20.01.3%5.8×9 +28.9%

Universities only. The score blends citation excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Porphyrin Metabolism and Disorders, country by country

Is Porphyrin Metabolism and Disorders research growing?

Output in 2022-2025 was 5% higher than in 2018-2021, peaking in 2015. The fastest-growing topics are Porphyrin Metabolism and Disorders.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Porphyrin Metabolism and Disorders as a percentage of every work published that year, 0.0073% in 2024.

still counting0.025%0.050%0.075%Porphyrin Metabolism and Disorders0.0063% in 202519801990200020102020

Fractional works of Porphyrin Metabolism and Disorders over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Porphyrin Metabolism and Disorders10.1% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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