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Nonprofit · Cold Spring Harbor · United States

Cold Spring Harbor Laboratory

In research, Cold Spring Harbor Laboratory stands highest in Life Sciences (#203 of 6,403 worldwide), Biochemistry, Genetics and Molecular Biology (#226 of 2,964 worldwide) and Molecular Biology (#202 of 1,880 worldwide), 2022-now. Relative to its size it is most specialised in Molecular Biology (Molecular Biology is 9.7× its share of world research).

cshl.eduROR OpenAlex
World rank, 2022-now
#1,135
of 22,385 · #729 all time
Rank in United States
#249
of 3,332
Research works
4.7k
▼ 5% vs 2018-21
Citations
666k
143.2 per fractional work
Top-10% rate
19.3%
all institutions 10.0%
vs its own fields
1.22×
1.00× is exactly expected
Open access
56%
world 40%
International
17%
world 18%
Cold Spring Harbor Laboratory

What is Cold Spring Harbor Laboratory known for in research?

The fields where it stands highest, 2022-now, ranked among every institution above the floor in each field.

FieldWorld rankWhere that sitsTop-10% rateWorksAll time
Life SciencesDomain #203 of 6,403 19.7%226 #177
Biochemistry, Genetics and Molecular BiologyField #226 of 2,964 19.0%152 #210
Molecular BiologySubfield #202 of 1,880 19.8%101 #167
Health SciencesDomain #1,119 of 9,902 24.1%67 #583
MedicineField #1,103 of 8,541 23.9%64 #578

Each strip is that field's whole ranked pool, with the notch where Cold Spring Harbor Laboratory sits in it, in the colour of the band that rank falls in. The track under the rate is the rate itself: it carries no average mark, because the average differs by field (from about 6% in Dentistry to 21% in Economics).

Which of those standings moved

The same fields on both windows: where it stood over the whole record, and where it stands in 2022-now. The distance is the story, and it is the one thing the two rank columns above cannot show.

  1. Life Sciences#177 #203
  2. Biochemistry, Genetics and Molecular Biology#210 #226
  3. Molecular Biology#167 #202
  4. Health Sciences#583 #1,119
  5. Medicine#578 #1,103
all time2022-now, better2022-now, worse

A dot further right is a better standing. Fields it was not ranked in over the whole record are left out.

Which fields of science does Cold Spring Harbor Laboratory work in?

In 2022-now, 67% of research at Cold Spring Harbor Laboratory is in Life Sciences, 20% in Health Sciences. Its largest fields are Biochemistry, Genetics and Molecular Biology (45%), Medicine (19%), Neuroscience (11%). It does 4.8× the world's share of Life Sciences.

Life Sciences: 269 fractional works · 66.5% of its workBiochemistry, Genetics and Molecular Biology: 182 fractional works · 45.2% of its workMolecular Biology: 119 fractional works · 29.4% of its workGenetics: 24 fractional works · 5.9% of its workCancer Research: 20 fractional works · 4.9% of its workCell Biology: 7 fractional works · 1.6% of its workBiophysics: 4 fractional works · 1.0% of its workBiotechnology: 4 fractional works · 0.9% of its workDevelopmental Biology: 1 fractional works · 0.3% of its workBiochemistry: 1 fractional works · 0.3% of its workAging: 1 fractional works · 0.2% of its workClinical Biochemistry: 1 fractional works · 0.2% of its workSmaller subfields together: 1 fractional works · 0.4% of its workNeuroscience: 46 fractional works · 11.3% of its workCognitive Neuroscience: 16 fractional works · 4.1% of its workCellular and Molecular Neuroscience: 15 fractional works · 3.8% of its workNeurology: 4 fractional works · 1.0% of its workDevelopmental Neuroscience: 3 fractional works · 0.9% of its workEndocrine and Autonomic Systems: 2 fractional works · 0.5% of its workSensory Systems: 2 fractional works · 0.5% of its workBehavioral Neuroscience: 2 fractional works · 0.4% of its workSmaller subfields together: 1 fractional works · 0.1% of its workAgricultural and Biological Sciences: 26 fractional works · 6.3% of its workPlant Science: 22 fractional works · 5.4% of its workEcology, Evolution, Behavior and Systematics: 1 fractional works · 0.4% of its workInsect Science: 1 fractional works · 0.2% of its workSmaller subfields together: 1 fractional works · 0.3% of its workImmunology and Microbiology: 14 fractional works · 3.5% of its workImmunology: 13 fractional works · 3.3% of its workSmaller subfields together: 1 fractional works · 0.2% of its workPharmacology, Toxicology and Pharmaceutics: 1 fractional works · 0.3% of its workHealth Sciences: 80 fractional works · 19.8% of its workMedicine: 77 fractional works · 19.1% of its workOncology: 25 fractional works · 6.1% of its workPulmonary and Respiratory Medicine: 6 fractional works · 1.4% of its workPsychiatry and Mental health: 5 fractional works · 1.3% of its workPhysiology: 5 fractional works · 1.2% of its workPublic Health, Environmental and Occupational Health: 4 fractional works · 1.0% of its workNeurology: 3 fractional works · 0.8% of its workGenetics: 3 fractional works · 0.8% of its workRadiology, Nuclear Medicine and Imaging: 3 fractional works · 0.7% of its workPathology and Forensic Medicine: 3 fractional works · 0.7% of its workEpidemiology: 2 fractional works · 0.5% of its workSurgery: 2 fractional works · 0.5% of its workObstetrics and Gynecology: 2 fractional works · 0.5% of its workEndocrinology, Diabetes and Metabolism: 2 fractional works · 0.4% of its workRheumatology: 2 fractional works · 0.4% of its workReproductive Medicine: 1 fractional works · 0.4% of its workPediatrics, Perinatology and Child Health: 1 fractional works · 0.3% of its workPharmacology: 1 fractional works · 0.3% of its workCardiology and Cardiovascular Medicine: 1 fractional works · 0.3% of its workHematology: 1 fractional works · 0.2% of its workImmunology and Allergy: 1 fractional works · 0.2% of its workSmaller subfields together: 4 fractional works · 1.0% of its workNursing: 2 fractional works · 0.6% of its workNutrition and Dietetics: 2 fractional works · 0.6% of its workHealth Professions: 0 fractional works · 0.1% of its workPhysical Sciences: 35 fractional works · 8.7% of its workComputer Science: 11 fractional works · 2.8% of its workArtificial Intelligence: 9 fractional works · 2.2% of its workSmaller subfields together: 2 fractional works · 0.6% of its workEngineering: 8 fractional works · 2.0% of its workBiomedical Engineering: 5 fractional works · 1.3% of its workElectrical and Electronic Engineering: 2 fractional works · 0.5% of its workSmaller subfields together: 1 fractional works · 0.2% of its workEnvironmental Science: 6 fractional works · 1.6% of its workEcology: 4 fractional works · 0.9% of its workSmaller subfields together: 3 fractional works · 0.7% of its workChemistry: 5 fractional works · 1.3% of its workOrganic Chemistry: 3 fractional works · 0.8% of its workSpectroscopy: 1 fractional works · 0.3% of its workSmaller subfields together: 0 fractional works · 0.1% of its workPhysics and Astronomy: 2 fractional works · 0.4% of its workMaterials Science: 1 fractional works · 0.4% of its workEarth and Planetary Sciences: 1 fractional works · 0.2% of its workMathematics: 0 fractional works · 0.0% of its workSocial Sciences: 20 fractional works · 5.0% of its workPsychology: 8 fractional works · 2.1% of its workSocial Psychology: 5 fractional works · 1.3% of its workExperimental and Cognitive Psychology: 2 fractional works · 0.5% of its workSmaller subfields together: 1 fractional works · 0.3% of its workDecision Sciences: 5 fractional works · 1.2% of its workInformation Systems and Management: 4 fractional works · 1.0% of its workSmaller subfields together: 1 fractional works · 0.2% of its workSocial Sciences: 4 fractional works · 1.0% of its workSociology and Political Science: 2 fractional works · 0.5% of its workSmaller subfields together: 2 fractional works · 0.5% of its workArts and Humanities: 2 fractional works · 0.6% of its workHistory and Philosophy of Science: 1 fractional works · 0.3% of its workPhilosophy: 1 fractional works · 0.2% of its workSmaller subfields together: 0 fractional works · 0.1% of its workEconomics, Econometrics and Finance: 0 fractional works · 0.1% of its workALL ITS WORKCold SpringHarbor Laboratory404fractional works, 2022-now
Life Sciences67%Physical Sciences9%Health Sciences20%Social Sciences5%

Each ring splits the one inside it: the four domains of science, their fields, their subfields. Size is fractional works in 2022-now. Every slice is a page; the interactive view zooms down to single topics and colours each by how much more of it this institution does than the world.

Its 4 domains and 24 fields, with their numbers
    1. Biochemistry, Genetics and Molecular Biology18245.2%
    2. Neuroscience4611.3%
    3. Agricultural and Biological Sciences266.3%
    4. Immunology and Microbiology143.5%
    5. Pharmacology, Toxicology and Pharmaceutics10.3%
    1. Medicine7719.1%
    2. Nursing20.6%
    3. Health Professions00.1%
    4. Veterinary00.0%
    1. Computer Science112.8%
    2. Engineering82.0%
    3. Environmental Science61.6%
    4. Chemistry51.3%
    5. Physics and Astronomy20.4%
    6. Materials Science10.4%
    7. Earth and Planetary Sciences10.2%
    8. Mathematics00.0%
    9. Energy00.0%
    1. Psychology82.1%
    2. Decision Sciences51.2%
    3. Social Sciences41.0%
    4. Arts and Humanities20.6%
    5. Economics, Econometrics and Finance00.1%
    6. Business, Management and Accounting00.0%
All of science, and how each field's share has moved since 1950: the Science domain explorer

What does Cold Spring Harbor Laboratory specialise in?

Where its research is concentrated relative to its size: Molecular Biology takes 9.7× the share of its output that it takes of world research.

  1. Molecular BiologySubfield · 118.6 works9.7×
← less than its size predicts1×more →

Location quotient, a volume reading rather than an impact one. It surfaces small, lopsided specialities.

Field profile

Location quotient across every field it publishes in: outside the ring is more than an institution of this size would be expected to publish, inside it is less.

Agricultural and Biological Sciences: 1.33× its world share, 26 worksAgricultural and Bio…Biochemistry, Genetics and Molecular Biology: 8.47× its world share, 182 worksBiochemistry, Geneti…Immunology and Microbiology: 3.47× its world share, 14 worksImmunology and Micro…Neuroscience: 6.96× its world share, 46 worksNeurosciencePharmacology, Toxicology and Pharmaceutics: 0.76× its world share, 1 worksPharmacology, Toxico…Chemistry: 0.81× its world share, 5 worksChemistryComputer Science: 0.36× its world share, 11 worksComputer ScienceEarth and Planetary Sciences: 0.13× its world share, 1 worksEarth and Planetary …Energy: 0.02× its world share, 0 worksEnergyEngineering: 0.14× its world share, 8 worksEngineeringEnvironmental Science: 0.32× its world share, 6 worksEnvironmental ScienceMaterials Science: 0.10× its world share, 1 worksMaterials ScienceMathematics: 0.04× its world share, 0 worksMathematicsPhysics and Astronomy: 0.17× its world share, 2 worksPhysics and AstronomyHealth Professions: 0.04× its world share, 0 worksHealth ProfessionsMedicine: 0.99× its world share, 77 worksMedicineNursing: 1.22× its world share, 2 worksNursingVeterinary: 0.04× its world share, 0 worksVeterinaryArts and Humanities: 0.21× its world share, 2 worksArts and HumanitiesDecision Sciences: 1.22× its world share, 5 worksDecision SciencesEconomics, Econometrics and Finance: 0.04× its world share, 0 worksEconomics, Econometr…Psychology: 0.68× its world share, 8 worksPsychologySocial Sciences: 0.08× its world share, 4 worksSocial Sciences1×world share
more than its size predictsabout as predictedless

Rings at 0.5×, 1× and 2×. Widest outward: Biochemistry, Genetics and Molecular Biology, 8.5×. Every wedge is a field page.

All 23 fields, with their numbers
  1. Biochemistry, Genetics and Molecular Biology8.47×182 works
  2. Neuroscience6.96×46 works
  3. Immunology and Microbiology3.47×14 works
  4. Agricultural and Biological Sciences1.33×26 works
  5. Nursing1.22×2 works
  6. Decision Sciences1.22×5 works
  7. Medicine0.99×77 works
  8. Chemistry0.81×5 works
  9. Pharmacology, Toxicology and Pharmaceutics0.76×1 works
  10. Psychology0.68×8 works
  11. Computer Science0.36×11 works
  12. Environmental Science0.32×6 works
  13. Arts and Humanities0.21×2 works
  14. Physics and Astronomy0.17×2 works
  15. Engineering0.14×8 works
  16. Earth and Planetary Sciences0.13×1 works
  17. Materials Science0.10×1 works
  18. Social Sciences0.08×4 works
  19. Mathematics0.04×0 works
  20. Health Professions0.04×0 works
  21. Veterinary0.04×0 works
  22. Economics, Econometrics and Finance0.04×0 works
  23. Energy0.02×0 works

Who are the top researchers at Cold Spring Harbor Laboratory?

Ranked on the quality score, Gregory James Hannon, David Arthur Tuveson and Michael H. Wigler lead among researchers whose main affiliation is Cold Spring Harbor Laboratory.

  1. 1 Gregory James Hannon United States · #89 worldwide 152k citations · 521 works
  2. 2 David Arthur Tuveson United States · #1,067 worldwide 89k citations · 958 works
  3. 3 Michael H. Wigler United States · #5,064 worldwide 67k citations · 360 works
  4. 4 T Gingeras United States · #6,023 worldwide 156k citations · 1,015 works
  5. 5 Z. Josh Huang United States · #7,277 worldwide 28k citations · 171 works
  6. 6 Bruce Stillman United States · #7,418 worldwide 43k citations · 364 works
  7. 7 Robert A. Martienssen United States · #7,469 worldwide 43k citations · 250 works
  8. 8 William Richard McCombie United States · #7,989 worldwide 92k citations · 325 works
  9. 9 Doreen Ware United States · #8,951 worldwide 43k citations · 270 works
  10. 10 Christopher R. Vakoc United States · #10,353 worldwide 25k citations · 412 works
All ranked researchers at Cold Spring Harbor Laboratory

What are the most cited papers from Cold Spring Harbor Laboratory?

The most cited paper from Cold Spring Harbor Laboratory is "STAR: ultrafast universal RNA-seq aligner" (Alexander Yu. Dobin, Carrie Davis, Felix Schlesinger et al., 2012), with 58,026 citations. Next come "Initial sequencing and analysis of the human genome" (24,745) and "A global reference for human genetic variation" (20,444).

Most cited papers
#PaperReleasedCitations
1 STAR: ultrafast universal RNA-seq aligner Alexander Yu. Dobin, Carrie Davis, Felix Schlesinger et al. · Bioinformatics Open access 25 Oct 2012 58,026
2 Initial sequencing and analysis of the human genome Eric S. Lander et al. · Nature Open access252 authors Feb 2001 24,745
3 A global reference for human genetic variation Corresponding authors et al. · Nature Open access815 authors 29 Sep 2015 20,444
4 An integrated encyclopedia of DNA elements in the human genome Ian Dunham et al. · Nature Open access442 authors Sep 2012 19,751
5 Studies on transformation of Escherichia coli with plasmids Douglas Hanahan · Journal of Molecular Biology Jun 1983 11,339
All 60 most cited papers, with filters and sorting

Which keywords describe research at Cold Spring Harbor Laboratory?

By fractional works in 2022-now, weighted toward what it does more of than the world: Gene Expression, Cancer, Tumor Microenvironment, Epigenetic Regulation, Transcription Factors, Immunotherapy, RNA-Seq and Gene Regulation.

▲ more of its work than of the world's◆ about the world's share▼ less than the world's

Size is fractional works in 2022-now in the topics tagged with each word; colour is the word's share of this institution's work against its share of the world's. The 40 words are chosen for being large and distinctive. Each links to the topic it comes from most.

All 40 words, with their numbers
  1. Gene Expression32▲ 12×18 topics
  2. Cancer31▲ 5.7×38 topics
  3. Inflammation19▲ 2.2×45 topics
  4. Immunotherapy17▲ 6.0×14 topics
  5. Tumor Microenvironment16▲ 8.8×7 topics
  6. Epigenetic Regulation16▲ 19×6 topics
  7. Transcription Factors16▲ 30×5 topics
  8. RNA-Seq15▲ 32×2 topics
  9. Metabolism12▲ 5.7×12 topics
  10. Neurological Disorders12▲ 5.1×10 topics
  11. Gene Regulation11▲ 29×5 topics
  12. Chemotherapy11▲ 3.8×12 topics
  13. Chromatin10▲ 51×2 topics
  14. Genomic Instability10▲ 21×2 topics
  15. Neuronal Circuits10▲ 31×2 topics
  16. Neurobiology9▲ 8.9×6 topics
  17. Synaptic Plasticity9▲ 11×5 topics
  18. Phylogenetic Analysis9▲ 7.0×6 topics
  19. Epigenetics9▲ 48×3 topics
  20. Dendritic Spines9▲ 28×2 topics
  21. Targeted Therapy9▲ 9.6×4 topics
  22. Data Integration8▲ 12×3 topics
  23. Transcriptional Regulation8▲ 13×9 topics
  24. Alternative Splicing8▲ 40×1 topic
  25. Cancer Progression8▲ 11×6 topics
  26. RNA-Binding Proteins8▲ 40×1 topic
  27. Single-Cell8▲ 38×1 topic
  28. Transcriptomics8▲ 38×1 topic
  29. MicroRNA8▲ 16×2 topics
  30. Histone Modifications8▲ 74×1 topic
  31. Transcription8▲ 74×1 topic
  32. Cell-Free DNA8▲ 19×2 topics
  33. GABAergic8▲ 38×1 topic
  34. Neurotransmission8▲ 38×1 topic
  35. Brain Development8▲ 11×5 topics
  36. Genetic Variation8▲ 8.4×8 topics
  37. Population Genetics8▲ 13×5 topics
  38. Functional Genomics7▲ 23×2 topics
  39. Cancer Genomics7▲ 25×1 topic
  40. Mutational Signatures7▲ 25×1 topic

Which research topics does Cold Spring Harbor Laboratory publish most on?

By volume in 2022-now: RNA Research and Splicing, Single-cell and spatial transcriptomics, Genomics and Chromatin Dynamics and Neuroscience and Neuropharmacology Research.

RNA Research and Splicing8RNA Research and Splicing: 8 fractional worksSingle-cell and spatial …8Single-cell and spatial transcriptomics: 8 fractional worksGenomics and Chromatin Dynamics: 8 fractional worksNeuroscience and Neuroph…8Neuroscience and Neuropharmacology Research: 8 fractional worksGenomics and Phylogeneti…7Genomics and Phylogenetic Studies: 7 fractional worksCancer Genomics and Diagnostics: 7 fractional worksRNA and protein synthesis mechanisms: 7 fractional worksRNA modifications and ca…7RNA modifications and cancer: 7 fractional worksNeural dynamics and brain function: 7 fractional worksPlant Molecular Biology Research: 6 fractional works
Molecular BiologyCellular and Molecular NeuroscienceCancer ResearchCognitive Neuroscience1 others

Area is fractional works; colour is the subfield each topic belongs to.

  1. 1 RNA Research and Splicing Molecular Biology 8 works
  2. 2 Single-cell and spatial transcriptomics Molecular Biology 8 works
  3. 3 Genomics and Chromatin Dynamics Molecular Biology 8 works
  4. 4 Neuroscience and Neuropharmacology Research Cellular and Molecular Neuroscience 8 works
  5. 5 Genomics and Phylogenetic Studies Molecular Biology 7 works
  6. 6 Cancer Genomics and Diagnostics Cancer Research 7 works
  7. 7 RNA and protein synthesis mechanisms Molecular Biology 7 works
  8. 8 RNA modifications and cancer Molecular Biology 7 works
  9. 9 Neural dynamics and brain function Cognitive Neuroscience 7 works
  10. 10 Plant Molecular Biology Research Plant Science 6 works

How open and international is its research?

Against the world's own shares: the tick on each track. Both are shares of its output, so they sit on one scale and can be read against each other as well as against the world.

openly available55.8%not open44.2%

World: 40% of research is openly available.

with international co-authors16.8%domestic only83.2%

World: 18% is written across borders.

How has Cold Spring Harbor Laboratory's research output changed?

Output in 2022-2025 was 5% lower than in 2018-2021.

still counting1990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Cold Spring Harbor Laboratory as a percentage of every work published that year, 0.0016% in 2024.

still counting0.010%0.020%Cold Spring Harbor Laboratory0.0014% in 202519801990200020102020

Fractional works of Cold Spring Harbor Laboratory over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year, against all institutions in the same year.

still counting20%40%Cold Spring Harbor Laboratory17.8% in 2025all institutions10.0% in 2025200020102020

Of each year's output, the share that reached the world's 10% most cited for its field and year. Peak 38.4% in 2002.

Other research institutions in Cold Spring Harbor

All research institutions in Cold Spring Harbor

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Cold Spring Harbor Laboratory on Science Explorer

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Its overall standing, then the domains, fields and subfields where Cold Spring Harbor Laboratory is in the world's top ten or its top 1%. Each has an image of its own.

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Questions people ask

What does Cold Spring Harbor Laboratory research?

In research, Cold Spring Harbor Laboratory stands highest in Life Sciences (#203 of 6,403 worldwide), Biochemistry, Genetics and Molecular Biology (#226 of 2,964 worldwide) and Molecular Biology (#202 of 1,880 worldwide), 2022-now. Relative to its size it is most specialised in Molecular Biology (Molecular Biology is 9.7× its share of world research).

All 1,273 questions in the Question Catalogue

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