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Topic · Molecular Biology

Genomics and Chromatin Dynamics

Genomics and Chromatin Dynamics is a research topic within Molecular Biology. Science Explorer counts 45k research works in it since 1950. 9.8% of them reached the world's top 10% most cited for their field and year.

This cluster of papers focuses on the regulation of chromatin structure and function, including topics such as histone modifications, transcriptional regulation, enhancers, DNA elements, 3D genome organization, and nucleosome positioning. The research covers a wide range of molecular mechanisms involved in controlling gene expression and epigenetic processes.

  • Chromatin
  • Transcription
  • Histone Modifications
  • Epigenetics
  • Gene Regulation
  • Enhancers
  • DNA Elements
  • 3D Genome Organization
  • Transcription Factors
  • Nucleosome Positioning
Research works
45k
fractional, since 1950
In the world top 10%
4.4k
per year above
Top-10% rate
9.8%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
-6%
the tick is no change
Largest producer
United States
41% of the 10 largest, 2022-now
Genomics and Chromatin Dynamics

Which countries lead Genomics and Chromatin Dynamics research?

By volume, the United States and China publish the most (2.1k and 1.2k works in 2022-now).

By volume, 2022-now

  1. 1 United States 2.1k works
  2. 2 China 1.2k works
  3. 3 Germany 309 works
  4. 4 United Kingdom 308 works
  5. 5 Japan 294 works
  6. 6 France 234 works
  7. 7 India 185 works
  8. 8 Canada 143 works
  9. 9 Italy 136 works
  10. 10 Russia 132 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

United States: 41.5%China: 24.3%Germany: 6.1%United Kingdom: 6.1%6 others listed: 22.1%41%largest
United States2,112 · 41.5%China1,240 · 24.3%Germany309 · 6.1%United Kingdom308 · 6.1%6 others listed1,125 · 22.1%

Shares of the rows listed above, not of the whole node.

Which institutions lead Genomics and Chromatin Dynamics research?

By volume in 2022-now, Centre National de la Recherche Scientifique publishes the most Genomics and Chromatin Dynamics research, followed by National Institutes of Health and Harvard University.

By volume, 2022-now

  1. 1 Centre National de la Recherche ScientifiqueFrance 95 works
  2. 2 National Institutes of HealthUnited States 93 works
  3. 3 Harvard UniversityUnited States 92 works
  4. 4 Russian Academy of SciencesRussia 78 works
  5. 5 Chinese Academy of SciencesChina 75 works
  6. 6 University of North Carolina at Chapel HillUnited States 74 works
  7. 7 Peking UniversityChina 45 works
  8. 8 Stanford UniversityUnited States 44 works
  9. 9 Max Planck SocietyGermany 44 works
  10. 10 Johns Hopkins UniversityUnited States 43 works

Who are the leading researchers in Genomics and Chromatin Dynamics?

The most-cited researchers publishing on Genomics and Chromatin Dynamics include Eric S. Lander, Rob Knight and George Davey Smith.

  1. 1 Eric S. Lander United States 524k citations
  2. 2 Rob Knight United States 468k citations
  3. 3 George Davey Smith United Kingdom 435k citations
  4. 4 Richard M. Durbin United Kingdom 410k citations
  5. 5 Mark J. Daly United States 403k citations
  6. 6 Stacey L. Gabriel United States 402k citations
  7. 7 Peer Bork Germany 396k citations
  8. 8 Robert John Tibshirani United States 396k citations
  9. 9 Guido Kroemer France 386k citations
  10. 10 Bert Vogelstein United States 373k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Genomics and Chromatin Dynamics?

The most cited paper in Genomics and Chromatin Dynamics is "Basic local alignment search tool" (Stephen F. Altschul, Warren R. Gish, Webb Miller et al., 1990), with 95,803 citations. Next come "Initial sequencing and analysis of the human genome" (24,745) and "Model-based Analysis of ChIP-Seq (MACS)" (20,527).

Most cited papers
#PaperReleasedCitations
1 Basic local alignment search tool Stephen F. Altschul, Warren R. Gish, Webb Miller et al. · Journal of Molecular Biology Oct 1990 95,803
2 Initial sequencing and analysis of the human genome Eric S. Lander et al. · Nature Open access252 authors Feb 2001 24,745
3 Model-based Analysis of ChIP-Seq (MACS) Yong Zhang, Tao Liu, Clifford A. Meyer et al. · Genome biology Open access 17 Sep 2008 20,527
4 An integrated encyclopedia of DNA elements in the human genome Ian Dunham et al. · Nature Open access442 authors Sep 2012 19,751
5 Molecular portraits of human breast tumours Charles M. Perou, Thérese Sørlie, Michael B. Eisen et al. · Nature 17 Aug 2000 16,552
All 100 most cited papers, with filters and sorting

Where is Genomics and Chromatin Dynamics research done?

The largest centres of Genomics and Chromatin Dynamics research in 2022-now are Beijing (China), New York (United States), Paris (France) and Shanghai (China). Among places with at least 20 works in it, it is an unusually large share of all research in Chevy Chase and Bethesda.

Largest cities, 2022-now

  1. 1 BeijingChina 209 works
  2. 2 New YorkUnited States 127 works
  3. 3 ParisFrance 125 works
  4. 4 ShanghaiChina 121 works
  5. 5 CambridgeUnited States 90 works
  6. 6 TokyoJapan 88 works
  7. 7 LondonUnited Kingdom 87 works
  8. 8 MoscowRussia 85 works
  9. 9 GuangzhouChina 82 works
  10. 10 BethesdaUnited States 80 works

Where it is the local speciality

  1. Chevy ChaseUS · 34.4 works63×
  2. BethesdaUS · 79.7 works11×
← less than its size predicts1×more →

Location quotient: how much more of its research is in Genomics and Chromatin Dynamics than the world average.

See Genomics and Chromatin Dynamics on the map

Where is the best place to study Genomics and Chromatin Dynamics?

Among universities, judged by research, Harvard University, Massachusetts Institute of Technology and University of Cambridge score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%10%20%30%mean 19.21%fractional works in this field (log) →share of work in the world top 10% →Oncode InstituteUniversity of Cambri…Massachusetts Instit…Harvard University
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Harvard UniversityUnited States 74.717.6%5.4×92 -17.7%
2Massachusetts Institute of TechnologyUnited States 71.920.4%8.4×31 -2.9%
3University of CambridgeUnited Kingdom 69.521.6%5.8×37 +5.3%
4Oncode InstituteNetherlands 67.827.2%86.6×13 -0.3%
5Stanford UniversityUnited States 63.918.5%5.6×44 -15.3%
6Peking UniversityChina 59.916.2%4.2×45 +9.4%
7University of CopenhagenDenmark 59.319.1%3.5×18 +20.5%
8University of California, San FranciscoUnited States 57.417.3%6.2×24 -4.8%
9Rockefeller UniversityUnited States 57.117.4%47.5×16 -1.3%
10University of OxfordUnited Kingdom 57.016.8%4.2×31 -18.5%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Genomics and Chromatin Dynamics, country by country

Is Genomics and Chromatin Dynamics research growing?

Output in 2022-2025 was 6% lower than in 2018-2021, peaking in 2013.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Genomics and Chromatin Dynamics as a percentage of every work published that year, 0.023% in 2024.

still counting0.025%0.050%0.075%Genomics and Chromatin Dynamics0.023% in 202519801990200020102020

Fractional works of Genomics and Chromatin Dynamics over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%Genomics and Chromatin Dynamics9.6% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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