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Topic · Molecular Biology

Connective Tissue Growth Factor Research

Connective Tissue Growth Factor Research is a research topic within Molecular Biology. Science Explorer counts 8.3k research works in it since 1951. 10.0% of them reached the world's top 10% most cited for their field and year.

This cluster of papers focuses on the role of CCN proteins, particularly Connective Tissue Growth Factor (CTGF), in various signaling pathways such as TGF-ß and BMP, and their involvement in processes like angiogenesis, fibrosis, cell adhesion, regulation of gene expression, cancer progression, and wound healing.

  • Connective Tissue Growth Factor
  • CCN Family
  • Matricellular Proteins
  • Angiogenesis
  • Fibrosis
  • TGF-ß Signaling
  • Cell Adhesion
  • Regulation of Gene Expression
  • Cancer Progression
  • Wound Healing
Research works
8.3k
fractional, since 1951
In the world top 10%
837
per year above
Top-10% rate
10.0%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
-3%
the tick is no change
Largest producer
China
53% of the 10 largest, 2022-now
Connective Tissue Growth Factor Research

Which countries lead Connective Tissue Growth Factor Research research?

By volume, China and the United States publish the most (665 and 261 works in 2022-now).

By volume, 2022-now

  1. 1 China 665 works
  2. 2 United States 261 works
  3. 3 Japan 78 works
  4. 4 Germany 53 works
  5. 5 United Kingdom 40 works
  6. 6 Italy 37 works
  7. 7 South Korea 33 works
  8. 8 India 31 works
  9. 9 Iran 26 works
  10. 10 Russia 26 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

China: 53.2%United States: 20.9%Japan: 6.2%Germany: 4.3%6 others listed: 15.5%53%largest
China665 · 53.2%United States261 · 20.9%Japan78 · 6.2%Germany53 · 4.3%6 others listed194 · 15.5%

Shares of the rows listed above, not of the whole node.

Which institutions lead Connective Tissue Growth Factor Research research?

By volume in 2022-now, Shanghai Jiao Tong University publishes the most Connective Tissue Growth Factor Research research, followed by Sun Yat-sen University and Nanjing Medical University.

By volume, 2022-now

  1. 1 Shanghai Jiao Tong UniversityChina 20 works
  2. 2 Sun Yat-sen UniversityChina 18 works
  3. 3 Nanjing Medical UniversityChina 16 works
  4. 4 Southern Medical UniversityChina 14 works
  5. 5 Sichuan UniversityChina 13 works
  6. 6 Okayama UniversityJapan 12 works
  7. 7 Central South UniversityChina 12 works
  8. 8 Zhejiang UniversityChina 11 works
  9. 9 Fudan UniversityChina 11 works
  10. 10 Harbin Medical UniversityChina 10 works

Who are the leading researchers in Connective Tissue Growth Factor Research?

The most-cited researchers publishing on Connective Tissue Growth Factor Research include Giuseppe Remuzzi, John P. A. Ioannidis and André Gerardus Uitterlinden.

  1. 1 Giuseppe Remuzzi Italy 328k citations
  2. 2 John P. A. Ioannidis United States 317k citations
  3. 3 André Gerardus Uitterlinden Netherlands 246k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Connective Tissue Growth Factor Research?

The most cited paper in Connective Tissue Growth Factor Research is "Sunitinib versus Interferon Alfa in Metastatic Renal-Cell Carcinoma" (Robert John Motzer, Thomas E. Hutson, Piotr Tomczak et al., 2007), with 5,801 citations. Next come "Transforming Growth Factor β in Tissue Fibrosis" (3,093) and "A multigenic program mediating breast cancer metastasis to bone" (2,627).

Most cited papers
#PaperReleasedCitations
1 Sunitinib versus Interferon Alfa in Metastatic Renal-Cell Carcinoma Robert John Motzer, Thomas E. Hutson, Piotr Tomczak et al. · New England Journal of Medicine Open access 10 Jan 2007 5,801
2 Transforming Growth Factor β in Tissue Fibrosis Franklin H. Epstein, Wayne A. Border, Nancy A. Noble · New England Journal of Medicine 10 Nov 1994 3,093
3 A multigenic program mediating breast cancer metastasis to bone Yibin Kang, Peter M. Siegel, Weiping Shu et al. · Cancer Cell Open access Jun 2003 2,627
4 Avelumab plus Axitinib versus Sunitinib for Advanced Renal-Cell Carcinoma Robert John Motzer et al. · New England Journal of Medicine Open access 16 Feb 2019 2,590
5 Role of Transforming Growth Factor β in Human Disease Gerard C. Blobe, William P. Schiemann, Harvey F. Lodish · New England Journal of Medicine 4 May 2000 2,439
All 100 most cited papers, with filters and sorting

Where is Connective Tissue Growth Factor Research research done?

The largest centres of Connective Tissue Growth Factor Research research in 2022-now are Beijing (China), Shanghai (China), Guangzhou (China) and Wuhan (China). Among places with at least 20 works in it, it is an unusually large share of all research in Guangzhou.

Largest cities, 2022-now

  1. 1 BeijingChina 56 works
  2. 2 ShanghaiChina 53 works
  3. 3 GuangzhouChina 46 works
  4. 4 WuhanChina 28 works
  5. 5 Xi'anChina 23 works
  6. 6 NanjingChina 23 works
  7. 7 HangzhouChina 23 works
  8. 8 ChengduChina 19 works
  9. 9 JinanChina 19 works
  10. 10 ChangshaChina 18 works

Where it is the local speciality

  1. GuangzhouCN · 45.9 works3.5×
← less than its size predicts1×more →

Location quotient: how much more of its research is in Connective Tissue Growth Factor Research than the world average.

See Connective Tissue Growth Factor Research on the map

Where is the best place to study Connective Tissue Growth Factor Research?

Among universities, judged by research, Sun Yat-sen University, Harvard University and Southern Medical University score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%10%20%mean 12.65%fractional works in this field (log) →share of work in the world top 10% →Harvard UniversitySun Yat-sen UniversityShanghai Jiao Tong U…Southern Medical Uni…
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Sun Yat-sen UniversityChina 66.816.9%6.4×18 -7.4%
2Harvard UniversityUnited States 66.521.4%2.4×10 +31.5%
3Southern Medical UniversityChina 59.612.0%16.6×14 +51.1%
4Shanghai Jiao Tong UniversityChina 57.614.1%5.2×20 -15.2%
5Harbin Medical UniversityChina 53.316.8%22.7×10 +82.8%
6Nanjing Medical UniversityChina 52.915.3%13.2×16 -23.8%
7Sichuan UniversityChina 46.210.6%4.2×13 +36.1%
8University of MichiganUnited States 44.48.5%4.6×9 +27.7%
9Zhejiang UniversityChina 36.710.8%3.1×11 -17.4%
10Okayama UniversityJapan 36.60.1%37.3×12 +85.7%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Connective Tissue Growth Factor Research, country by country

Is Connective Tissue Growth Factor Research research growing?

Output in 2022-2025 was 3% lower than in 2018-2021, peaking in 2013.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Connective Tissue Growth Factor Research as a percentage of every work published that year, 0.0051% in 2024.

still counting0.0050%0.010%0.015%Connective Tissue Growth Factor Research0.0058% in 202519801990200020102020

Fractional works of Connective Tissue Growth Factor Research over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Connective Tissue Growth Factor Research10.0% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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