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Topic · Molecular Biology

Heat shock proteins research

Heat shock proteins research is a research topic within Molecular Biology. Science Explorer counts 24k research works in it since 1950. 10.0% of them reached the world's top 10% most cited for their field and year.

This cluster of papers explores the role of molecular chaperones, such as Hsp70 and Hsp90, in protein folding, proteostasis, cancer therapy, cell stress responses, and innate immunity. It delves into the mechanisms of chaperone machinery, protein quality control, and their implications in disease intervention.

  • Molecular Chaperones
  • Protein Folding
  • Proteostasis
  • Heat Shock Proteins
  • Chaperone Machinery
  • Cancer Therapy
  • Cell Stress
  • Hsp70 and Hsp90
  • Protein Quality Control
  • Innate Immunity
Research works
24k
fractional, since 1950
In the world top 10%
2.4k
per year above
Top-10% rate
10.0%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
-10%
the tick is no change
Largest producer
China
41% of the 10 largest, 2022-now
Heat shock proteins research

Which countries lead Heat shock proteins research research?

By volume, China and the United States publish the most (935 and 588 works in 2022-now).

By volume, 2022-now

  1. 1 China 935 works
  2. 2 United States 588 works
  3. 3 India 164 works
  4. 4 Germany 126 works
  5. 5 Japan 117 works
  6. 6 Russia 86 works
  7. 7 South Korea 78 works
  8. 8 Italy 78 works
  9. 9 United Kingdom 66 works
  10. 10 France 63 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

China: 40.6%United States: 25.5%India: 7.2%Germany: 5.5%6 others listed: 21.2%41%largest
China935 · 40.6%United States588 · 25.5%India164 · 7.2%Germany126 · 5.5%6 others listed488 · 21.2%

Shares of the rows listed above, not of the whole node.

Which institutions lead Heat shock proteins research research?

By volume in 2022-now, Russian Academy of Sciences publishes the most Heat shock proteins research research, followed by Chinese Academy of Agricultural Sciences and Chinese Academy of Sciences.

By volume, 2022-now

  1. 1 Russian Academy of SciencesRussia 41 works
  2. 2 Chinese Academy of Agricultural SciencesChina 30 works
  3. 3 Chinese Academy of SciencesChina 30 works
  4. 4 Centre National de la Recherche ScientifiqueFrance 19 works
  5. 5 National Institutes of HealthUnited States 17 works
  6. 6 Sun Yat-sen UniversityChina 17 works
  7. 7 Shanghai Jiao Tong UniversityChina 15 works
  8. 8 Zhejiang UniversityChina 14 works
  9. 9 Harvard UniversityUnited States 13 works
  10. 10 Indian Council of Agricultural ResearchIndia 13 works

Who are the leading researchers in Heat shock proteins research?

The most-cited researchers publishing on Heat shock proteins research include Peer Bork, Guido Kroemer and Shizuo Akira.

  1. 1 Peer Bork Germany 396k citations
  2. 2 Guido Kroemer France 386k citations
  3. 3 Shizuo Akira Japan 342k citations
  4. 4 Jun Wang China 340k citations
  5. 5 Matthias Mann Germany 308k citations
  6. 6 Dan J. Stein South Africa 306k citations
  7. 7 John Q. Trojanowski United States 286k citations
  8. 8 Todd R. Golub United States 283k citations
  9. 9 Frank B. Hu United States 281k citations
  10. 10 Matthew M. Meyerson United States 280k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Heat shock proteins research?

The most cited paper in Heat shock proteins research is "Heat Shock Protein A12B Protects Vascular Endothelial Cells Against Sepsis-Induced Acute Lung Injury in Mice" (Yi Chen, Lei Wang, Qiuxiang Kang et al., 2017), with 10,709 citations. Next come "The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation" (6,131) and "Plasma Hsp90 levels in patients with systemic sclerosis and relation to lung and skin involvement: a cross-sectional and longitudinal study" (5,057).

Most cited papers
#PaperReleasedCitations
1 Heat Shock Protein A12B Protects Vascular Endothelial Cells Against Sepsis-Induced Acute Lung Injury in Mice Yi Chen, Lei Wang, Qiuxiang Kang et al. · Cellular Physiology and Biochemistry Open access 2017 10,709
2 The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation Peter Walter, David Ron · Science 24 Nov 2011 6,131
3 Plasma Hsp90 levels in patients with systemic sclerosis and relation to lung and skin involvement: a cross-sectional and longitudinal study Hana Štorkánová, Sabína Oreská, Maja Špiritović et al. · Scientific Reports Open access 7 Jan 2021 5,057
4 HEAT-SHOCK PROTEINS, MOLECULAR CHAPERONES, AND THE STRESS RESPONSE: Evolutionary and Ecological Physiology Martin E. Feder, Gretchen E. Hofmann · Annual Review of Physiology Review Mar 1999 4,360
5 Molecular chaperones in protein folding and proteostasis F. Ulrich Hartl, Andreas Bracher, Manajit K. Hayer-Hartl · Nature Jul 2011 3,635
All 100 most cited papers, with filters and sorting

Where is Heat shock proteins research research done?

The largest centres of Heat shock proteins research research in 2022-now are Beijing (China), Shanghai (China), Guangzhou (China) and Nanjing (China).

Largest cities, 2022-now

  1. 1 BeijingChina 113 works
  2. 2 ShanghaiChina 55 works
  3. 3 GuangzhouChina 49 works
  4. 4 NanjingChina 40 works
  5. 5 MoscowRussia 40 works
  6. 6 SeoulSouth Korea 34 works
  7. 7 WuhanChina 34 works
  8. 8 HangzhouChina 32 works
  9. 9 ParisFrance 30 works
  10. 10 ChangshaChina 26 works
See Heat shock proteins research on the map

Where is the best place to study Heat shock proteins research?

Among universities, judged by research, University of Notre Dame, Technical University of Munich and Sichuan University score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%10%20%30%mean 16.18%fractional works in this field (log) →share of work in the world top 10% →University of Notre …Sichuan UniversityTechnical University…Harvard University
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1University of Notre DameUnited States 73.026.9%14.6×11 -0.5%
2Technical University of MunichGermany 70.113.9%5.7×13 +0.7%
3Sichuan UniversityChina 58.122.0%2.2×13 +56.2%
4Harvard UniversityUnited States 54.812.0%1.6×13 -32.0%
5Sun Yat-sen UniversityChina 53.513.6%3.1×16 -17.8%
6Nanjing Agricultural UniversityChina 47.821.5%8.9×9 -13.4%
7Zhejiang UniversityChina 47.414.8%2.0×14 -6.9%
8Shanghai Jiao Tong UniversityChina 46.99.4%2.0×15 +2.3%
9University of PennsylvaniaUnited States 46.08.6%3.9×10 +76.4%
10Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 45.219.1%3.9×11 +8.5%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Heat shock proteins research, country by country

Is Heat shock proteins research research growing?

Output in 2022-2025 was 10% lower than in 2018-2021, peaking in 2015.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Heat shock proteins research as a percentage of every work published that year, 0.011% in 2024.

still counting0.020%0.040%0.060%Heat shock proteins research0.011% in 202519801990200020102020

Fractional works of Heat shock proteins research over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Heat shock proteins research10.2% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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