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Topic · Molecular Biology

Biochemical and Molecular Research

Biochemical and Molecular Research is a research topic within Molecular Biology. Science Explorer counts 39k research works in it since 1950. 10.0% of them reached the world's top 10% most cited for their field and year.

This cluster of papers focuses on the intricate regulation and metabolic pathways of nucleotide biosynthesis, including purine and pyrimidine biosynthesis. It explores the structure, function, and inhibition of key enzymes such as CTP synthase, IMP dehydrogenase, and dihydroorotate dehydrogenase. The cluster also delves into disorders related to nucleotide metabolism, such as Lesch-Nyhan syndrome.

  • Nucleotide Metabolism
  • Enzyme Regulation
  • Purine Biosynthesis
  • Pyrimidine Biosynthesis
  • Metabolic Enzymes
  • Transition State Analogue Inhibitors
  • CTP Synthase
  • IMP Dehydrogenase
  • Dihydroorotate Dehydrogenase
  • Lesch-Nyhan Syndrome
Research works
39k
fractional, since 1950
In the world top 10%
3.9k
per year above
Top-10% rate
10.0%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
+3%
the tick is no change
Largest producer
United States
33% of the 10 largest, 2022-now
Biochemical and Molecular Research

Which countries lead Biochemical and Molecular Research research?

By volume, the United States and China publish the most (888 and 737 works in 2022-now).

By volume, 2022-now

  1. 1 United States 888 works
  2. 2 China 737 works
  3. 3 India 291 works
  4. 4 Germany 157 works
  5. 5 Japan 149 works
  6. 6 United Kingdom 132 works
  7. 7 France 105 works
  8. 8 Italy 102 works
  9. 9 Russia 87 works
  10. 10 Brazil 80 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

United States: 32.6%China: 27.0%India: 10.7%Germany: 5.8%6 others listed: 24.0%33%largest
United States888 · 32.6%China737 · 27.0%India291 · 10.7%Germany157 · 5.8%6 others listed655 · 24.0%

Shares of the rows listed above, not of the whole node.

Which institutions lead Biochemical and Molecular Research research?

By volume in 2022-now, Russian Academy of Sciences publishes the most Biochemical and Molecular Research research, followed by Chinese Academy of Sciences and Centre National de la Recherche Scientifique.

By volume, 2022-now

  1. 1 Russian Academy of SciencesRussia 43 works
  2. 2 Chinese Academy of SciencesChina 43 works
  3. 3 Centre National de la Recherche ScientifiqueFrance 33 works
  4. 4 National Institutes of HealthUnited States 29 works
  5. 5 Harvard UniversityUnited States 26 works
  6. 6 Sun Yat-sen UniversityChina 17 works
  7. 7 Shanghai Jiao Tong UniversityChina 17 works
  8. 8 Sichuan UniversityChina 15 works
  9. 9 Jiangnan UniversityChina 15 works
  10. 10 Zhejiang UniversityChina 15 works

Who are the leading researchers in Biochemical and Molecular Research?

The most-cited researchers publishing on Biochemical and Molecular Research include Rob Knight, George Davey Smith and Peer Bork.

  1. 1 Rob Knight United States 468k citations
  2. 2 George Davey Smith United Kingdom 435k citations
  3. 3 Peer Bork Germany 396k citations
  4. 4 Guido Kroemer France 386k citations
  5. 5 Bert Vogelstein United States 373k citations
  6. 6 Jun Wang China 340k citations
  7. 7 Giuseppe Remuzzi Italy 328k citations
  8. 8 Matthias Egger Switzerland 326k citations
  9. 9 Matthias Mann Germany 308k citations
  10. 10 Róbert Langer United States 303k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Biochemical and Molecular Research?

The most cited paper in Biochemical and Molecular Research is "Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix" (Dorothee Claudia Liebschner et al., 2019), with 7,679 citations. Next come "Genetic regulatory mechanisms in the synthesis of proteins" (6,659) and "Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase" (5,982).

Most cited papers
#PaperReleasedCitations
1 Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix Dorothee Claudia Liebschner et al. · Acta Crystallographica Section D Structural Biology Open access Oct 2019 7,679
2 Genetic regulatory mechanisms in the synthesis of proteins François Jacob, Jacques Monod · Journal of Molecular Biology Jun 1961 6,659
3 Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase Donald B. Smith, Kevin Scot Johnson · Gene Jul 1988 5,982
4 A Protein Binding Assay for Adenosine 3′:5′-Cyclic Monophosphate Alfred G. Gilman · Proceedings of the National Academy of Sciences Open access Sep 1970 3,270
5 The growing impact of click chemistry on drug discovery Hartmuth Christian Kolb, Karl Barry Sharpless · Drug Discovery Today Dec 2003 3,149
All 100 most cited papers, with filters and sorting

Where is Biochemical and Molecular Research research done?

The largest centres of Biochemical and Molecular Research research in 2022-now are Beijing (China), Shanghai (China), Moscow (Russia) and Paris (France). Among places with at least 20 works in it, it is an unusually large share of all research in Bethesda.

Largest cities, 2022-now

  1. 1 BeijingChina 103 works
  2. 2 ShanghaiChina 87 works
  3. 3 MoscowRussia 53 works
  4. 4 ParisFrance 47 works
  5. 5 HangzhouChina 43 works
  6. 6 GuangzhouChina 43 works
  7. 7 TokyoJapan 42 works
  8. 8 New YorkUnited States 40 works
  9. 9 NanjingChina 35 works
  10. 10 LondonUnited Kingdom 30 works

Where it is the local speciality

  1. BethesdaUS · 23.9 works5.4×
← less than its size predicts1×more →

Location quotient: how much more of its research is in Biochemical and Molecular Research than the world average.

See Biochemical and Molecular Research on the map

Where is the best place to study Biochemical and Molecular Research?

Among universities, judged by research, Harvard University, Sun Yat-sen University and Cornell University score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%10%20%mean 16.53%fractional works in this field (log) →share of work in the world top 10% →Sun Yat-sen UniversityCornell UniversityHarvard UniversityJiangnan University
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Harvard UniversityUnited States 80.815.3%2.6×26 -13.4%
2Sun Yat-sen UniversityChina 65.022.8%2.6×17 +127.6%
3Cornell UniversityUnited States 61.917.9%2.8×12 -2.1%
4Jiangnan UniversityChina 57.813.6%7.9×15 +63.7%
5Johns Hopkins UniversityUnited States 57.610.7%2.9×14 +14.3%
6University of TorontoCanada 56.117.6%1.6×10 +32.9%
7Fudan UniversityChina 55.320.5%2.6×13 +96.5%
8University of MichiganUnited States 53.210.7%3.0×15 +54.6%
9Zhejiang University of TechnologyChina 52.814.6%8.1×14 +66.3%
10Peking UniversityChina 52.221.6%1.7×11 +23.0%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Biochemical and Molecular Research, country by country

Is Biochemical and Molecular Research research growing?

Output in 2022-2025 was 3% higher than in 2018-2021, peaking in 2025. The fastest-growing topics are Biochemical and Molecular Research.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Biochemical and Molecular Research as a percentage of every work published that year, 0.016% in 2024.

still counting0.050%0.10%0.15%Biochemical and Molecular Research0.015% in 202519801990200020102020

Fractional works of Biochemical and Molecular Research over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Biochemical and Molecular Research10.2% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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