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Topic · Molecular Biology

Heme Oxygenase-1 and Carbon Monoxide

Heme Oxygenase-1 and Carbon Monoxide is a research topic within Molecular Biology. Science Explorer counts 25k research works in it since 1950. 10.0% of them reached the world's top 10% most cited for their field and year.

This cluster of papers focuses on the research related to heme oxygenase and carbon monoxide, highlighting their roles in inflammation modulation, cytoprotection, oxidative stress, vascular biology, neuroprotection, and therapeutic applications. The papers cover a wide range of topics including the molecular mechanisms, signaling pathways, and potential therapeutic interventions involving heme oxygenase-1 and carbon monoxide.

  • Heme Oxygenase-1
  • Carbon Monoxide
  • Inflammation
  • Cytoprotection
  • Bilirubin
  • Therapeutic Applications
  • Oxidative Stress
  • Vascular Biology
  • Neuroprotection
  • Apoptosis
Research works
25k
fractional, since 1950
In the world top 10%
2.5k
per year above
Top-10% rate
10.0%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
+3%
the tick is no change
Largest producer
China
47% of the 10 largest, 2022-now
Heme Oxygenase-1 and Carbon Monoxide

Which countries lead Heme Oxygenase-1 and Carbon Monoxide research?

By volume, China and the United States publish the most (1.4k and 692 works in 2022-now).

By volume, 2022-now

  1. 1 China 1.4k works
  2. 2 United States 692 works
  3. 3 India 190 works
  4. 4 Japan 150 works
  5. 5 South Korea 113 works
  6. 6 Germany 96 works
  7. 7 Türkiye 95 works
  8. 8 Italy 91 works
  9. 9 United Kingdom 85 works
  10. 10 Spain 68 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

China: 47.2%United States: 23.1%India: 6.4%Japan: 5.0%6 others listed: 18.3%47%largest
China1,410 · 47.2%United States692 · 23.1%India190 · 6.4%Japan150 · 5.0%6 others listed549 · 18.3%

Shares of the rows listed above, not of the whole node.

Which institutions lead Heme Oxygenase-1 and Carbon Monoxide research?

By volume in 2022-now, Chinese Academy of Sciences publishes the most Heme Oxygenase-1 and Carbon Monoxide research, followed by Shanghai Jiao Tong University and Sichuan University.

By volume, 2022-now

  1. 1 Chinese Academy of SciencesChina 28 works
  2. 2 Shanghai Jiao Tong UniversityChina 27 works
  3. 3 Sichuan UniversityChina 26 works
  4. 4 Harvard UniversityUnited States 24 works
  5. 5 Wenzhou Medical UniversityChina 23 works
  6. 6 Zhejiang UniversityChina 23 works
  7. 7 Sun Yat-sen UniversityChina 23 works
  8. 8 Anhui Medical UniversityChina 23 works
  9. 9 Capital Medical UniversityChina 23 works
  10. 10 Central South UniversityChina 23 works

Who are the leading researchers in Heme Oxygenase-1 and Carbon Monoxide?

The most-cited researchers publishing on Heme Oxygenase-1 and Carbon Monoxide include Guido Kroemer, Zulfiqar Ahmed Bhutta and Shizuo Akira.

  1. 1 Guido Kroemer France 386k citations
  2. 2 Zulfiqar Ahmed Bhutta Pakistan 371k citations
  3. 3 Shizuo Akira Japan 342k citations
  4. 4 Emelia J. Benjamin United States 341k citations
  5. 5 Jun Wang China 340k citations
  6. 6 Giuseppe Remuzzi Italy 328k citations
  7. 7 Gregory Y.H. Lip United Kingdom 311k citations
  8. 8 Róbert Langer United States 303k citations
  9. 9 Frank B. Hu United States 281k citations
  10. 10 Ted R. Miller United States 279k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Heme Oxygenase-1 and Carbon Monoxide?

The most cited paper in Heme Oxygenase-1 and Carbon Monoxide is "Repertoires of Autophagy in the Pathogenesis of Ocular Diseases" (Yujie Li, Qin Li Jiang, Guo-Fan Cao et al., 2015), with 16,339 citations. Next come "The Carbon Monoxide-binding Pigment of Liver Microsomes" (11,871) and "A role for mitochondria in NLRP3 inflammasome activation" (5,609).

Most cited papers
#PaperReleasedCitations
1 Repertoires of Autophagy in the Pathogenesis of Ocular Diseases Yujie Li, Qin Li Jiang, Guo-Fan Cao et al. · Cellular Physiology and Biochemistry Open access 2015 16,339
2 The Carbon Monoxide-binding Pigment of Liver Microsomes Tsuneo Omura, Ryo Sato · Journal of Biological Chemistry Open access Jul 1964 11,871
3 A role for mitochondria in NLRP3 inflammasome activation Rongbin Zhou, Amir Sadegh Yazdi, Philippe Menu et al. · Nature Dec 2010 5,609
4 The NLRP3 inflammasome: molecular activation and regulation to therapeutics Karen V. Swanson, Meng Deng, Jenny P.‐Y. Ting · Nature reviews. Immunology ReviewOpen access 29 Apr 2019 4,877
5 Release of chromatin protein HMGB1 by necrotic cells triggers inflammation Paola Scaffidi, Tom Misteli, Marco Emilio Bianchi · Nature 11 Jul 2002 4,239
All 98 most cited papers, with filters and sorting

Where is Heme Oxygenase-1 and Carbon Monoxide research done?

The largest centres of Heme Oxygenase-1 and Carbon Monoxide research in 2022-now are Beijing (China), Shanghai (China), Guangzhou (China) and Wuhan (China). Among places with at least 20 works in it, it is an unusually large share of all research in Wenzhou.

Largest cities, 2022-now

  1. 1 BeijingChina 133 works
  2. 2 ShanghaiChina 96 works
  3. 3 GuangzhouChina 85 works
  4. 4 WuhanChina 53 works
  5. 5 ChengduChina 51 works
  6. 6 NanjingChina 50 works
  7. 7 HangzhouChina 46 works
  8. 8 SeoulSouth Korea 44 works
  9. 9 ChongqingChina 40 works
  10. 10 JinanChina 40 works

Where it is the local speciality

  1. WenzhouCN · 26.1 works7.7×
← less than its size predicts1×more →

Location quotient: how much more of its research is in Heme Oxygenase-1 and Carbon Monoxide than the world average.

See Heme Oxygenase-1 and Carbon Monoxide on the map

Where is the best place to study Heme Oxygenase-1 and Carbon Monoxide?

Among universities, judged by research, Soochow University, Wuhan University and Harvard University score highest, combining citation excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%20%40%mean 21.65%fractional works in this field (log) →share of work in the world top 10% →Chengdu University o…Wuhan UniversitySoochow UniversityHarvard University
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Citation excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Soochow UniversityChina 70.824.9%5.9×20 +54.1%
2Wuhan UniversityChina 68.828.0%4.4×21 +3.9%
3Harvard UniversityUnited States 67.916.6%2.2×24 +1.3%
4Chengdu University of Traditional Chinese MedicineChina 64.634.0%11.6×10 +371.8%
5Central South UniversityChina 64.118.0%3.5×23 +20.4%
6Zhengzhou UniversityChina 63.730.4%4.3×18 +65.3%
7Wenzhou Medical UniversityChina 63.113.3%13.7×23 +22.1%
8Anhui Medical UniversityChina 63.015.8%14.7×23 +80.5%
9Shanghai Jiao Tong UniversityChina 62.117.5%2.8×27 +3.6%
10Southern Medical UniversityChina 61.618.0%8.3×18 +24.6%

Universities only. The score blends citation excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Heme Oxygenase-1 and Carbon Monoxide, country by country

Is Heme Oxygenase-1 and Carbon Monoxide research growing?

Output in 2022-2025 was 3% higher than in 2018-2021, peaking in 2022. The fastest-growing topics are Heme Oxygenase-1 and Carbon Monoxide.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Heme Oxygenase-1 and Carbon Monoxide as a percentage of every work published that year, 0.016% in 2024.

still counting0.020%0.040%0.060%Heme Oxygenase-1 and Carbon Monoxide0.015% in 202519801990200020102020

Fractional works of Heme Oxygenase-1 and Carbon Monoxide over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Heme Oxygenase-1 and Carbon Monoxide10.1% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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