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Topic · Molecular Biology

Retinoids in leukemia and cellular processes

Retinoids in leukemia and cellular processes is a research topic within Molecular Biology. Science Explorer counts 33k research works in it since 1950. 10.0% of them reached the world's top 10% most cited for their field and year.

This cluster of papers explores the role of retinoic acid in various biological processes, including its involvement in acute promyelocytic leukemia, gene expression regulation, vitamin A metabolism, and embryonic development. It also discusses the interaction of retinoic acid with nuclear receptors such as RXR, the use of arsenic trioxide in treatment, and the potential for differentiation therapy.

  • Retinoic Acid
  • Acute Promyelocytic Leukemia
  • RXR
  • PML Nuclear Bodies
  • Arsenic Trioxide
  • Gene Expression Regulation
  • Vitamin A Metabolism
  • Nuclear Receptors
  • Differentiation Therapy
  • Embryonic Development
Research works
33k
fractional, since 1950
In the world top 10%
3.3k
per year above
Top-10% rate
10.0%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
+3%
the tick is no change
Largest producer
China
37% of the 10 largest, 2022-now
Retinoids in leukemia and cellular processes

Which countries lead Retinoids in leukemia and cellular processes research?

By volume, China and the United States publish the most (1k and 763 works in 2022-now).

By volume, 2022-now

  1. 1 China 1k works
  2. 2 United States 763 works
  3. 3 India 236 works
  4. 4 Japan 149 works
  5. 5 Italy 97 works
  6. 6 Germany 96 works
  7. 7 Brazil 93 works
  8. 8 Türkiye 92 works
  9. 9 United Kingdom 89 works
  10. 10 Iran 88 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

China: 37.0%United States: 28.2%India: 8.7%Japan: 5.5%6 others listed: 20.5%37%largest
China1,001 · 37.0%United States763 · 28.2%India236 · 8.7%Japan149 · 5.5%6 others listed555 · 20.5%

Shares of the rows listed above, not of the whole node.

Which institutions lead Retinoids in leukemia and cellular processes research?

By volume in 2022-now, Shanghai Jiao Tong University publishes the most Retinoids in leukemia and cellular processes research, followed by Harvard University and Chinese Academy of Medical Sciences & Peking Union Medical College.

By volume, 2022-now

  1. 1 Shanghai Jiao Tong UniversityChina 31 works
  2. 2 Harvard UniversityUnited States 27 works
  3. 3 Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 24 works
  4. 4 Zhejiang UniversityChina 24 works
  5. 5 The University of Texas MD Anderson Cancer CenterUnited States 24 works
  6. 6 Soochow UniversityChina 20 works
  7. 7 Sun Yat-sen UniversityChina 19 works
  8. 8 Peking UniversityChina 19 works
  9. 9 Harbin Medical UniversityChina 18 works
  10. 10 Sichuan UniversityChina 18 works

Who are the leading researchers in Retinoids in leukemia and cellular processes?

The most-cited researchers publishing on Retinoids in leukemia and cellular processes include Walter Churchill Willett, Guido Kroemer and Zulfiqar Ahmed Bhutta.

  1. 1 Walter Churchill Willett United States 411k citations
  2. 2 Guido Kroemer France 386k citations
  3. 3 Zulfiqar Ahmed Bhutta Pakistan 371k citations
  4. 4 Elaine R. Mardis United States 346k citations
  5. 5 Shizuo Akira Japan 342k citations
  6. 6 Cyrus Cooper United Kingdom 342k citations
  7. 7 Jun Wang China 340k citations
  8. 8 Robert A. Weinberg United States 301k citations
  9. 9 Salim Yusuf Canada 294k citations
  10. 10 John Q. Trojanowski United States 286k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Retinoids in leukemia and cellular processes?

The most cited paper in Retinoids in leukemia and cellular processes is "Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal" (Antonio Ayala, Mario Muñoz, Sandro Argüelles, 2014), with 6,379 citations. Next come "Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a" (5,154) and "The retinoblastoma protein and cell cycle control" (4,913).

Most cited papers
#PaperReleasedCitations
1 Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal Antonio Ayala, Mario Muñoz, Sandro Argüelles · Oxidative Medicine and Cellular Longevity Open access 2014 6,379
2 Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a Manuel Serrano, Athena W. Lin, Mila E. McCurrach et al. · Cell Open access Mar 1997 5,154
3 The retinoblastoma protein and cell cycle control Robert A. Weinberg · Cell Open access May 1995 4,913
4 Cloning of a novel receptor expressed in rat prostate and ovary. George G. J. M. Kuiper, Eva Enmark, Markku Pelto‐Huikko et al. · Proceedings of the National Academy of Sciences Open access 11 Jun 1996 4,820
5 Genomic Classification and Prognosis in Acute Myeloid Leukemia Elli Papaemmanuil et al. · New England Journal of Medicine Open access 8 Jun 2016 4,520
All 100 most cited papers, with filters and sorting

Where is Retinoids in leukemia and cellular processes research done?

The largest centres of Retinoids in leukemia and cellular processes research in 2022-now are Beijing (China), Shanghai (China), Guangzhou (China) and Hangzhou (China). Among places with at least 20 works in it, it is an unusually large share of all research in Houston and Suzhou.

Largest cities, 2022-now

  1. 1 BeijingChina 105 works
  2. 2 ShanghaiChina 80 works
  3. 3 GuangzhouChina 57 works
  4. 4 HangzhouChina 49 works
  5. 5 HoustonUnited States 41 works
  6. 6 ParisFrance 40 works
  7. 7 WuhanChina 38 works
  8. 8 TokyoJapan 36 works
  9. 9 LondonUnited Kingdom 36 works
  10. 10 SeoulSouth Korea 36 works

Where it is the local speciality

  1. HoustonUS · 41.0 works4.6×
  2. SuzhouCN · 21.3 works3.5×
← less than its size predicts1×more →

Location quotient: how much more of its research is in Retinoids in leukemia and cellular processes than the world average.

See Retinoids in leukemia and cellular processes on the map

Where is the best place to study Retinoids in leukemia and cellular processes?

Among universities, judged by research, Harvard University, Shanghai Jiao Tong University and Shanghai University of Traditional Chinese Medicine score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%10%20%30%mean 18.22%fractional works in this field (log) →share of work in the world top 10% →Shanghai University …Zhejiang UniversityShanghai Jiao Tong U…Harvard University
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Harvard UniversityUnited States 73.016.6%2.6×27 -6.3%
2Shanghai Jiao Tong UniversityChina 62.716.7%3.3×31 -0.4%
3Shanghai University of Traditional Chinese MedicineChina 60.928.3%9.6×8 +109.8%
4Zhejiang UniversityChina 60.517.4%2.8×24 +15.4%
5Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 55.813.0%7.0×24 +14.6%
6Huazhong University of Science and TechnologyChina 54.826.5%2.4×14 +87.9%
7Johns Hopkins UniversityUnited States 54.816.5%2.6×13 +0.2%
8Central South UniversityChina 52.518.8%2.7×17 +12.7%
9Peking UniversityChina 50.513.0%2.9×19 +10.7%
10Sichuan UniversityChina 50.215.4%2.4×18 +108.9%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Retinoids in leukemia and cellular processes, country by country

Is Retinoids in leukemia and cellular processes research growing?

Output in 2022-2025 was 3% higher than in 2018-2021, peaking in 2009. The fastest-growing topics are Retinoids in leukemia and cellular processes.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Retinoids in leukemia and cellular processes as a percentage of every work published that year, 0.015% in 2024.

still counting0.025%0.050%0.075%Retinoids in leukemia and cellular processes0.016% in 202519801990200020102020

Fractional works of Retinoids in leukemia and cellular processes over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Retinoids in leukemia and cellular processes10.1% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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